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Articles by Olufunmiso Olusola Olajuyigbe
Total Records ( 2 ) for Olufunmiso Olusola Olajuyigbe
  Olufunmiso Olusola Olajuyigbe , Tolulope Esther Onibudo , Roger Murugas Coopoosamy , Anofi Omotayo Tom Ashafa and Anthony Jide Afolayan
  Background and Objective: Trilepisium madagascariense DC. is a medicinal plant used in the treatment of gastrointestinal infections in Nigeria. The aim of the study was to investigate the antimicrobial activities and determine the pharmacologically bioactive compounds present in this plant to justify its traditional folkloric use in treating diarrhoea. Materials and Methods: The pharmacologically bioactive compounds in the ethanol stem back extract of Trilepisium madagascariense were determined using gas chromatography-mass spectrometry and its antimicrobial activities were assayed in vitro by agar well diffusion and macrobroth dilution techniques against different microbial isolates. Results: The mass spectra of the identified compounds in the extract at different retention time showed the presence of 1-Heptatriacotanol, Betulin, ethyl ester of hexadecanoic acid, Desulphosinigrin, N-methyl-N-[4-(3-hydroxypyrrolidinyl) -2-butynyl]-acetamine, Paromomycin, 5-hydroxymethylfurfural, 1-4-Hydroxylysine lactone and 5-amino-1H-imidazole-4-carboxamide, amongst other bioactive compounds of therapeutic potentials. The antibacterial activities showed that the inhibition zones ranged between 20 and 30±1.0 mm at the highest concentration and the antifungal activities against the fungal isolates ranged between 15 and 25±1.0 mm. Although the Minimum Inhibitory Concentrations (MICs) ranged between 1.25 and 5.0 mg mL–1 and the minimum bactericidal concentrations (MBCs) was between 5.0 and 10.0 mg mL–1 against the bacterial isolates, the MICs and the minimum fungicidal concentrations (MFCs) ranged from 1.563-6.25 mg mL–1 against the fungal isolates. Conclusion: Although the clinical isolates were more inhibited by the extract than the bacterial strains used as control, this study showed that the pharmacological effects of Trilepisium madagascariense depended on bioactive compounds identified. The presence of paromomycin with antidiarrhoeal activity in the extract justifies the use of this plant in the folkloric treatment of gastrointestinal infections. This plant is, therefore, a significant source for isolating novel drugs having significant therapeutic potentials.
  Olufunmiso Olusola Olajuyigbe and Oluwafeyikemi O. Adekola
  Background: Several in vivo studies indicated that interactions between antacids and some therapeutic agents could result in treatment failures. Most of these studies have failed to take cognizance of the in vitro effects of these interactions on infectious agents. Hence, this study investigated the interactions between erythromycin and polyvalent metallic ions and the effects of combining them against some clinical bacterial isolates in vitro. Methods: Different concentrations of erythromycin ranging between 2.5 and 30.0 μg mL-1 and their combination with different concentrations, 0.05-1.0 mg mL-1, of polyvalent metallic ions were tested against some clinical bacterial isolates. After the incubation period, inhibition zones from erythromycin alone and its combination with polyvalent metallic ions were measured and subjected to statistical analysis. Result: There was antagonistic interaction between erythromycin and the polyvalent metallic ions resulting in a significant reduction in the antibacterial activity of erythromycin on the clinical isolates. The possibility of bacterial resistant development as a result of combining these two drugs was observed while treatment failure was suggested by the associated reduction of the inhibition zones. Conclusion: In conclusion, combining erythromycin and polyvalent metallic ions should be discouraged in chemotherapy since the observed antagonistic interaction could result in development of bacterial resistance or treatment failure.
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