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Articles by Okwesili Fred Chiletugo Nwodo
Total Records ( 2 ) for Okwesili Fred Chiletugo Nwodo
  Uzuazokaro Mark-Maria Agatemor , Okwesili Fred Chiletugo Nwodo , Idakwoji Precious Adejoh and Chioma Assumpta Anosike
  Background and Objective: Research on liver diseases have been on increase and have become a global concern. Cucumis sativus has been reported to have anti-oxidant activity, high flavonoid content, anti-inflammatory and analgesic activity and may likely of help in the management of liver disease. The hepatoprotective effect of the homogenate of Cucumis sativus fruit were therefore studied and histopathological assessment of the liver damage was done. Materials and Methods: The fresh fruit of Cucumis sativus was homogenized and used for all experimental analysis. The effects of the fruit homogenate on liver function biomarkers and lipid profile in rats intoxicated with carbon tetrachloride (CCl4) were evaluated using standard biochemical methods. Data were analyzed using SPSS and two-way ANOVA; the acceptance level of significance was p<0.05. Results: Treatment of rats with the homogenate of Cucumis sativus fruits significantly (p<0.05) decreased CCl4-induced elevated levels of the liver enzymes and total bilirubin in the serum when compared to positive control. The homogenate also attenuated the CCl4-induced elevation of LDL, total cholesterol and triacylglycerol concentration and ameliorated the induced depletion of HDL. Pre-treatment with Cucumis sativus fruit homogenate significantly improved the structure of hepatic cells. The homogenate showed a sign of liver cell protection comparable to that of the standard drug-silymarin. Conclusion: The results of this study demonstrated that the homogenate was effective in the prevention of CCl4-induced hepatic damage in rats and may improve the liver integrity of consumers.
  Ugochi Olivia Njoku , Martins Obinna Ogugofor and Okwesili Fred Chiletugo Nwodo
  Background and Objective: Ficus capensis is one of the plants used in folklore medicine in Nigeria, for the treatment of various disease conditions and promotion of vascular health. This study was undertaken to investigate its cardioprotective potential against carbontetrachloride (CCl4)-induced myocardial necrosis in rats. Materials and Methods:Albino rats were divided into four main groups: normal control, CCl4 control, 1.2 mg kg–1 b.wt., aspirin pre-treated and Ficus capensis extract pre-treated groups. Extract was administered orally at doses of 100, 200, 300 and 400 mg kg–1 b.wt., for 7 days to evaluate their effect on CCl4-induced cardiotoxicity. Aspirin was used as standard drug. On day 7, cardiotoxicity was induced in animals of CCl4 control, aspirin and extract pre-treatment groups. Histopathological examination was performed to evaluate the basic action of extract and statistical differences were assessed using one-way ANOVA and Duncan's multiple range test with SPSS version 22.0. Results: CCl4 intoxication in CCl4 treated rats caused significant (p<0.05) increases in serum contents of cardiac biomarker enzymes and raise in lipid peroxidation whereas significant (p<0.05) decreases in cardiac enzymatic antioxidant and glutathione reductase contents were observed when compared to normal control. Pre-treatment with Ficus capensis stem bark extract expressed cardioprotective ability against CCl4-induced oxidative changes in myocardium by significantly (p<0.05) altering levels of cardiac biomarker enzymes towards normal, enhancing the activity of suppressed antioxidant enzymes and lessening lipid peroxidation level. Histopathological examination of cardiac tissues, following extract pre-treatment showed correlation with serological studies. Conclusion: Based on these findings, Ficus capensis stem bark is potent against CCl4-induced oxidative stress in heart due to its antioxidant and cell stabilization property.
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