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Articles by Odile Ouwe Missi Oukem-Boyer
Total Records ( 2 ) for Odile Ouwe Missi Oukem-Boyer
  Ibrahim Dan Dano , Odile Ouwe Missi Oukem-Boyer , Ali Elhadji Mahamane and Hassimi Sadou
  Background: To analyze whether the determination of interleukin-6 levels in cerebrospinal fluid is useful as a biomarker for the severity of bacterial meningitis. Methodology: Cerebrospinal fluid was obtained from 120 patients aged 0-15 years with meningitis. They were classified as having bacterial meningitis (n = 85) or aseptic meningitis (n = 35) according to the cerebrospinal fluid white blood cell count, microbiological culture and molecular methods. Interleukin-6 levels were determined by enzyme-linked immunosorbent assay. Results: No significant change in the mean interleukin-6 level on the basis of clinical signs was observed in patients with bacterial meningitis. However, the cerebrospinal fluid total protein level was elevated in patients with alertness problems (3.41±2.26 g L–1). There was a significant correlation (Pearson correlation p≤0.05) between the cerebrospinal fluid glucose and total protein levels in patients with bacterial meningitis. The mean cerebrospinal fluid interleukin-6 level (4,472.0±2,494.52 pg mL–1) in patients with bacterial meningitis whose disease outcome was fatal was significantly higher (p≤0.05) than that of those who survived the disease (2,983.28±2,612.13 pg mL–1). Conclusion: Interleukin-6 is a potential biomarker for identifying bacterial meningitis patients with a high risk of death who require intensive care.
  Ibrahim Dan Dano , Hassimi Sadou , Bassira Issaka and Odile Ouwe Missi Oukem-Boyer
  Objective: It is assessed whether the measurement of interleukin-6 in the cerebrospinal fluid can serve as a biomarker for the diagnosis of bacterial meningitis. Methodology: Cerebrospinal fluid was obtained from 152 patients aged 0-15 years suspected of having meningitis. These patients were classified into the following groups: Bacterial meningitis (n = 85), aseptic meningitis (n = 35) and non-meningitis/control (n = 32) based on leukocyte count and bacterial identification by culture and molecular biology. Interleukin-6 concentrations in cerebrospinal fluid were measured by enzyme-linked immunosorbent assay. Results: This study found a significant difference of the mean cerebrospinal fluid interleukin-6 level (p≤0.01) between patients with bacterial meningitis (3,538.69±2,560.78 pg mL–1) and patients with aseptic meningitis (332.51±470.69 pg mL–1) or those of the control group (205.83±79.39 pg mL–1). There was also a significant difference of the mean cerebrospinal fluid interleukin-6 level between patients with aseptic meningitis and those of the control group. Interleukin-6 had the highest area under the ROC curve: 0.94 (95% confidence interval: 0.901-0.979) compared to that of cerebrospinal fluid glucose and total protein. At a cut-off value of 1,065.96 pg mL–1, interleukin-6 had a sensitivity of 76.2% and specificity of 100%. Conclusion: Interleukin-6 is a potential biomarker for the differential diagnosis of meningitis.
 
 
 
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