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Articles by O.T. Kayode
Total Records ( 9 ) for O.T. Kayode
  A.A.A. Kayode and O.T. Kayode
  Several medicinal uses of the fluted pumpkin (Telfairia occidentalis) in traditional medicine have been documented. Although, many of these claims are yet to be validated by scientific researchers, a review of some investigated therapeutic activities of the plant are highlighted in this article. Experimental works done on Telfairia occidentalis especially in the field of Biochemistry were retrieved via Google search on the internet and studied carefully to identify any therapeutic activity reported on Telfairia occidentalis. It can be inferred that the ability of the plant to combat certain diseases may be due to its antioxidant and antimicrobial properties and its minerals (especially Iron), vitamins (especially vitamin A and C) and high protein contents. We therefore conclude that with further chemical manipulation and clinical investigations numerous drug designs could emerge from the plant. An effort to keep the plant protected and conserved is also advocated.
  A.A.A. Kayode , O.T. Kayode and A.A. Odetola
  It has been observed and established that enhancing the antioxidant defense system during the early phase of rehabilitation is important to the survival of wasting protein energy malnourished patients. In this study, comparison was made between the efficacy of dietary protein replenishment and supplementation with Telfairia occidentalis leaves, in the treatment of oxidative brain damage in the malnourished rats. The protein energy malnourished rats were produced by feeding weanling rats a protein deficient diet (2% protein) for 28 days. The malnourished rats were then divided into three dietary treatment groups, 20% protein+10% T. occidentalis group (PTG), 20% Protein Group (PG) and the 10% T. occidentalis group (TG). Significant decrease in brain size (p<0.01), activity of superoxide dismutase (p<0.01), catalase (p<0.01) and increased Malondialdehyde levels (p<0.01), indicative of oxidative damage were observed in the malnourished rats as compared with the control group. Reduced level of oxidative damage was however observed in group TG, PG and PTG , respectively. The result indicates that T. occidentalis leaves supplementation with protein repletion is more effective for recovery from protein energy malnutrition induced oxidative damage in rats than protein repletion alone.
  O.T. Kayode , O.A. Afolayan , A.A.A. Kayode and H.A. Mohammed
  Background and Objective: Imported chicken meat is smuggled into the country through the porous borders of Idiroko road which leads into Ota, Ogun State and sold to retailers in the open market. This study was carried out to assess and compare the nutritional composition and safety profile of the imported frozen, exotic commercial and indigenous chicken meats consumed in Ota metropolis. Materials and Methods: A total of 21 chicken meat samples were used for the study. Group 1, 2 and 3 comprise of seven samples each of imported frozen, exotic commercial and local chicken meat, respectively. The samples were digested and nutritional composition assessed by determination of proximate composition and essential elemental analysis. The safety profile was determined by quantification of levels of heavy metals (cadmium, lead and chromium), malondialdehyde and lipid profile of the chicken meats. Data analysis was done using SPSS version 15.0. The level of significance was set at p<0.05. Results: The proximate composition revealed significantly higher (p<0.05) levels of food nutrients in groups 2 and 3 compared to group 1. Similarly, the elemental analysis showed that groups 2 and 3 had significantly higher (p<0.05) levels of the elements and their concentration is within permissible limits compared to group 1 with significantly higher levels (p<0.05) of heavy metals such as lead, chromium and cadmium. Furthermore, the lipid profile analysis revealed significant increase (p<0.05) in levels of Low-Density Lipoprotein-Cholesterol (LDL-C), triglyceride and total cholesterol in the group 1 samples while group 3 has significantly higher levels (p<0.05) of High-Density Lipoprotein-Cholesterol (HDL-C). Malondialdehyde levels were also significantly higher in the group 1 samples compared to groups 2 and 3. Conclusion: The local and exotic commercial chicken meat are more nutritious and safer for consumption compared to the imported chicken meats sold in Ota, Ogun state.
  O.T. Kayode , A.A.A. Kayode and O.O. Awonuga
  There has been high incidence of malaria and typhoid co-infection in Nigeria lately but no documented study has really considered its impact on the biochemical status of the patients. The aim of this study was to investigate the effect of malaria and malaria-typhoid co-infection on some hematological and biochemical parameters in infected patients. A total of 66 febrile patients and 10 apparently healthy persons from Bells University of Technology and Covenant University Health Centers, Ota, Ogun State were screened for the presence of plasmodium falciparum and salmonella typhi. Levels of Neutrophils, Lymphocytes, White Blood Cells, Packed Cell Volume (PCV), Albumin, Urea, Glucose, Total Bilirubin, Total Protein and Creatinine were estimated in the blood plasma of the study groups. A significant increase (p<0.05) in Creatinine, Urea and Total Bilirubin levels, Neutrophils and White Blood Cell counts were observed in both the malaria and co-infected patients as compared to the control. However, Albumin, Glucose, PCV, Lymphocytes and Total Protein levels were significantly reduced (p<0.05) in both the malaria and co-infected patients. This study indicates alterations in these parameters and therefore recommends proper monitoring during treatment in order to reverse them to normal levels.
  O.O. Adewoyin , M. Omeje , E.S. Joel and O.T. Kayode
  The heterogeneous nature of the subsurface requires the use of factual information to deal with rather than empirical or generalized equations. Therefore, there is need to determine the actual rate of possible settlement in the soil before structures are built on it. This information will help to determining the type of foundation design and the kind of reinforcement that will be necessary in constructions. This study presents a simplified and a faster approach to determining foundation settlement in the soil using real field data acquired from seismic refraction techniques and cone penetration tests. This approach was also able to determine the depth of settlement of each strata of soil. The rate of settlement for the four profiles was found to vary between 0.019 and 0.035 m. The results obtained revealed the different depthof possible settlement.
  A.A.A. Kayode , O.T. Kayode , O.A. Aroyeun and M.C. Stephen
  The aim of this study was to assess the effects of short-term administration of some antiretroviral drugs on hematological and hepatic parameters in albino rats. The rats were treated with 0.43, 0.43, 0.27 and 0.21 mg kg-1 of Efavirenz, Abacavir, SNP 40 and Lamivudine respectively, for seven days. The control group received normal saline. On the eighth day, the rats were sacrificed; blood and liver were collected for White Blood Cell Count (WBC), Packed Cell Volume (PCV), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) analysis. All the drugs showed significant increase (p<0.05) in %WBC (43.0, 42.6, 52.3 and 37.4%) for Efavirenz, Abacavir, SNP 40 and Lamivudine respectively. Abacavir, SNP 40 and Lamivudine significantly decreased (p<0.05) ALP by 66.67, 84.75 and 56.24%, respectively while Efavirenz and Abacavir caused significant increase and decrease (p<0.05) in AST by 9.09 and 16.36% respectively. Efavirenz, Abacavir and Lamivudine caused significant increase (p<0.05) in ALT by 321.6, 497.6 and 177%, respectively. The drugs significantly increased the immunity of the animals and Efavirenz, Lamivudine and Abacavir caused hepatic damage. The clinical implication of our findings is that hepatoprotective agents should be included in the treatment regimen when administering antiretroviral drugs such as Efavirenz, Lamivudine and Abacavir.
  O.O. Adewoyin , E.S. Joel and O.T. Kayode
  Groundwater accounts for a major percentage of the world’s fresh water and it is fairly distributed all over the world. It has always been considered to be a readily available source of water for domestic, agricultural and industrial use. Various strategies have been adopted for the development and management of groundwater resource because of its importance to life. This presentation enumerated some of the factors affecting groundwater quality and its diminishing quantity. It also highlighted the effect of these on the economy, health and the environment. It was concluded that poverty can be reduced if conscious effort is made to develop and manage groundwater resource.
  O.T. Kayode , A.A. Kayode and A.A. Odetola
  Comparison was made between the efficacy of dietary protein replenishment and supplementation with Telfairia occidentalis leaves, in treatment of Protein Energy Malnutrition (PEM) induced liver damage. PEM rats were produced by feeding weanling rats a protein deficient diet (2% protein) for 28 days and then divided into four dietary treatment groups: 2% protein (group A; PEM control group); 20% protein and 10% T. occidentalis (group C); 20% protein (group D) and 10% T. occidentalis (group E). The protein deficient diet caused a significant increase (p<0.01) in hepatic malondialdehyde (MDA) level and the liver function enzymes alkaline phosphatase (ALP), alanine amino transferase (ALT) and aspartate amino transferase (AST) level in the serum. It also caused a marked reduction (p<0.01) in glutathione level, significant decrease (p<0.01) in the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) and significant damage to the hepatocytes. Recovery diets of protein alone and protein supplemented with T. occidentalis had significant effects on all the parameters. The MDA level and the serum liver function enzymes were significantly reduced (p<0.01), glutathione and antioxidant enzymes levels were markedly increased (p<0.01) and a highly significant hepatocyte healing observed in the histology images. The highest recovery was however observed in group C. Results indicate the restorative ability of T. occidentalis in treatment of oxidative stress induced liver damage in PEM rats.
  A.A.A. Kayode , O.T. Kayode and A.A. Odetola
  The effect of two extracts of Parquetina nigrescens on mucosal antioxidants defense system in ethanol-induced ulcer in rats was studied. Activities of superoxide dismutase (SOD), catalase (CAT) and levels of reduced glutathione (GSH) were determined in the gastric mucosa and liver of normal and experimental groups of rats. The rats were pretreated with 500 and 1000 mg kg-1 of hexane and chloroform extracts of P. nigrescens, respectively dissolved in olive oil for a period of 14 days prior to ethanol induction. It was found that prior to ulcer induction, 14 days pretreatment with hexane and chloroform extract P. nigrescenes significantly reduced ethanol-induced gastric damage. The levels of GSH and activities of the antioxidants enzymes (SOD and CAT) were depressed significantly (p<0.05) in the ulcerated rats when compared with that of normal control. The activity of SOD was lower significantly (p<0.05) in the ulcerated mucosa and liver of the experimental rats when compared to the normal control group. There was a significant increase (p<0.05) in the level of CAT in the groups pretreated with the extracts compared to the ethanol group. A similar result was observed for GSH. Pretreatment with hexane extract caused 75.43 and 74.55% elevations in the activities of SOD in the mucosa and liver homogenate, respectively. Similar elevations were observed in the group pretreated with the chloroform extract. The cimetidine group also caused 69.79 and 69.67% elevation in the SOD activity in the mucosa and liver homogenate, respectively. The pretreatment with P. nigrescens was found to exact a significant gastro protective and antiulcer effect partly by protecting against the ethanol-induced ulcerogenic effects in experimental rats and probably through the induction of antioxidant enzymes.
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