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Articles by O.S. Odesanmi
Total Records ( 5 ) for O.S. Odesanmi
  H.A. Ogbunugafor , V.I. Okochi , J. Okpuzor , O.S. Odesanmi and F.J. Ebigwe
  Bioassay guided-fractionation of Mitragyna ciliata Aubrev and Pellegr (Rubiaceae) ethanolic root extract at 100 mg kg-1 in T. brucei infected rats indicated that the bioactive constituent reside is present in the butanol fraction (inhibition = 66.61%). In vitro investigation of the extract revealed that it had low (25.55%) antioxidative property. Chemical analysis of the active fraction showed that it consists of alkaloids. The extract`s fraction had no effect on the heamatological profile of treated rats which remained consistent with the major characteristics of trypanosomiasis-anaemia, leucocytopaenia and thrombocytopaenia. Results of the in vivo evaluation of calcium concentration showed a significant difference (p<0.05), between the active butanol fraction (2.53 ± 0.036 mmol L-1) and the untreated/infected (17.79 ± 0.034 mmol L-1). A correlation existed between calcium concentration and parasiteamia in the active fraction (r = 0.40, p = 0.488) and the infected/untreated (r = -0.60, p = 0.29). These observations suggest that the active agent had an effect on the calcium metabolism in the animals which was deleterious to the parasites.
  M. Ozaslan , I.D. Karagoz , R.A. Lawal , I.H. Kilic , A. Cakir , O.S. Odesanmi , I. Guler and O.A.T. Ebuehi
  Background: Tetrapleura tetraptera fruit is widely used in Southern Nigeria for a range of pharmacological actions. Methodology/Principal Findings: In this study, the cytotoxic and antiproliferative effects of the ethanolic extract of fruit were studied in vitro and in vivo by using ehrlich ascites carcinoma cells and tumor modelling, respectively. Cytotoxic activity was determined by incubating the ehrlich ascites carcinoma cells with 0.1, 1, 10 and 100 μg mL–1 of the extract. In vivo study, 20, 40 and 80 mg kg–1 b.wt., doses of the extract was inoculated by intraperitoneal administration to mice following to carcinoma cells inoculation by same way. The extract was cytotoxic to carcinoma cells as assessed by both in vitro and in vivo experiments. Conclusion/Significance: The IC50 of the extract was found to be 250 μg mL–1. Results showed that the Tetrapleura tetraptera increased the life span of mice via reducing the number of the viable EAC cells, decreasing in ascites fluid volume and tumor burden. The DNA fragmentation assay also showed that it has a possible pro-apoptotic effect.
  S.A. Ojokuku , O.S. Odesanmi and O.A. Magbagbeola
  Croton penduliflorus, Hutch ubiquitous to Southern Nigeria is used in the treatment of diverse diseases. This study investigated the effects of oral administration of the petroleum ether extract on lipid, fasting blood sugar and haematological parameters of pregnant rabbits. Croton penduliflorus Seed Oil (CPSO) was prepared by soxhlet extraction of shelled, oven dried, ground seed sample with 40-60°C petroleum ether. Twenty five, acclimatized pregnant rabbits weighing 1-1.6 kg and at mid gestation were randomly allocated into 5 groups. Animals in group 1 served as the control while groups 2-4 received 50, 100, 150 mg kg-1 body weight oral dose of CPSO for 10 consecutive days. Animals in group 5 received one intramuscular injection of 2.73 mg kg-1 of medroxyprogesterone acetate. Withdrawal of treatment was followed by 18 h fast followed sacrifice after anesthesia. Fasting blood samples were collected from all the groups by cardiac puncture and analyzed for blood sugar, haematological and lipids profiles. Results were analyzed using student’s t-test and ANOVA. Medroxyprogesterone acetate significantly lowered (p<0.05) the fasting serum glucose, total cholesterol, PCV and MCV. CPSO at 50 mg kg-1 body weight elicited a similar but more pronounced response causing a highly significant (p<0.01) lowering of haemoglobin, total cholesterol. Croton penduliflorus is hypocholesterolemic but may predispose to anaemia.
  O.A. Abolaji , A.H. Adebayo and O.S. Odesanmi
  The nutritional potentials of three medicinal plant parts used by pregnant women in the western part of Nigeria Parinari polyandra, Blighia sapida and Xylopia aethiopica were evaluated through their proximate compositions as well as percentage mineral elements composition. Blighia sapida was high in crude fibre (44.09±2.20%) compared with Parinari polyandra and Xylopia aethiopica that were 4.21±1.10% and 12.14±0.70% respectively. Moisture contents of Xylopia aethiopica and Blighia sapida were 16.04±1.25% and 10.17±2.60% respectively while that of Parinari polyandra was 30.65±5.02%. The total ash contents of Parinari polyandra, Blighia sapida and Xylopia aethiopica were 2.53±1.20%, 3.66±1.20% and 4.37±0.85% respectively. The total fat of Xylopia aethiopica, Blighia sapida and Parinari polyandra were 9.55±2.10%, 1.25±0.20% and 0.53±0.15% respectively while the total protein of Blighia sapida, Xylopia aethiopica and Parinari polyandra were 2.1±0.25%, 2.1±0.20% and 7.09±0.20% respectively. The total carbohydrate of Xylopia aethiopica was 55.80±4.26%, that of Parinari polyandra was 54.27±3.20% and that of Blighia sapida was 39.45±2.20%. Xylopia aethiopica can be a good source of magnesium (2.236±0.095), phosphorus (0.620±0.04) and potassium (0.510±0.04) as the amount of these mineral elements were higher than that of the other plant parts with the exception of Parinari polyandra having 0.690±0.11% phosphorus. Blighia sapida is also a good source of phosphorus (0.400±0.20), magnesium (0.430±0.20) and calcium (0.348±0.15). Other mineral elements detected in reasonable amounts were calcium, zinc and sodium. Further tests revealed that heavy metals such as lead, chromium and cadmium were not detected. The results of this research indicated that the three plants parts have nutritional qualities that could provide the users with additional nutrients.
  A.O. Abolaji , A.H. Adebayo and O.S. Odesanmi
  The effects of the ethanolic fruit extract of Parinari polyandra on lipid profile and electrolyte levels in pregnant rabbits were investigated. Graded concentrations of 0, 10, 50 and 250 mg kg-1 body weight of the extracts were administered by gastric intubations for a period of 14 days from the 12th -25th day of gestation after which they were fasted for 18 h. The following lipid profiles were examined in the serum. Triglyceride, Total Cholesterol, High Density Lipoprotein (HDL) and Low Density Lipoprotein (LDL) cholesterol. Serum electrolytes also examined were: Sodium (Na+), Potassium (K+), Calcium(Ca2+), Chloride (Cl¯), Bicarbonate(HCO3¯) and Phosphorus (P). After these durations of treatment, there was significant elevation in triglycerides (p<0.01). The LDL/HDL Cholesterol ratio was greater than 0.3 in all the treated groups. Also, there were significant elevations in Na+ (p<0.05), Cl-(p<0.05), P (p<0.05) and Ca2+ (p<0.05). The result therefore suggests that the ethanolic fruit extract of Parinari polyandra may predispose to hyperlipidemia and electrolytes imbalance leading to hypercalcaemia and high risk of raised blood pressure in pregnant rabbits.
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