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Articles by O.S. Adeyemi
Total Records ( 5 ) for O.S. Adeyemi
  O.S. Adeyemi , M.A. Akanji , T.O. Johnson and J.T. Ekanem
  Iron is essential for living cells, including pathogenic microorganisms. So altered iron availability is often a key component in the host-pathogens interplay. Secondary to infection with pathogens, there is the activation of macrophages. Activated macrophages by action of inducible Nitric Oxide Synthase (iNOS) produce Nitric Oxide (NO) as part of host defense mechanism. However, production of nitric oxide as obtained in Trypanosoma brucei infection strongly correlates with increased cellular iron. The expanded free iron pool may become available to invading parasites and thus promotes proliferation. Establishing the link between these two important molecules may offer new treatment strategies for African trypanosomosis in the face of increasing toxicity and parasite resistance to drugs currently available for treatment of African trypanosomosis.
  O.S. Adeyemi , M.A. Akanji and J.T. Ekanem
  Previous report from our laboratory demonstrated the activity of ethanolic extract of Psidium guajava leaf against bloodstream forms of trypanosomes in an experimental infection. The present study investigated the mitigating effects of P. guajava leaf extract on Trypanosoma brucei brucei-induced changes in rat serum and tissue total protein, albumin, globulin, unconjugated bilirubin and total bilirubin. Our data revealed that trypanosome infection caused a rise in protein and globulin concentrations but reduced albumin concentrations were observed (p<0.05). There was also a significant increase in the serum and tissue bilirubin concentrations of the infected animals. In contrast, however, these biochemical alteration were less severe (p<0.05) in the treated group relative to the untreated counterparts. The data suggest the capacity of the ethanolic extract of P. guajava in downplaying the severity of the conditions usually associated with trypanosome infections.
  F.A. Sulaiman , M.A. Akanji , H.O.B. Oloyede , A.A. Sulaiman , A. Olatunde , E.B. Joel , T.H. Adewale , H.A. Adeboye , S.O. Idris , A.L. Quadri , R.A. Oyegoke and O.S. Adeyemi
  Study investigated the effect of oral administration of gold-silver nanoparticles on rat biochemical parameters and tissue morphology. Wistar rats weighing approximately 180±7 g were randomly assigned into four groups. Animals in the control group received distilled water once daily for 30 days while, those in the treatment groups were administered 10, 50 and 100 mg kg–1 b.wt. gold-silver nanoparticles. The rats were sacrificed under slight anesthesia, 24 h after the last treatments. Blood and vital organs including the heart, kidney and liver were collected and prepared for biochemical and histopathological determinations. Exposure to Ag/Au nanoparticles altered the rat serum lipid profile; lowering the HDL-C while raising the atherogenic index. Exposure of Ag/Au nanoparticles in rats caused significant alteration to the levels of serum albumin, total protein, bilirubin, urea and creatinine. The activities of alanine transaminase, aspartate transaminase and alkaline phosphatase in rat serum and tissues were also significantly altered by Ag/Au nanoparticles exposure. The histopathological examination revealed inflammation and cellular degeneration caused by exposure to the Ag/Au nanoparticles. We show evidence that Ag/Au nanoparticles elevated atherogenic index, as well as caused biochemical and morphological alterations, reminiscent of cellular injury.
  O.S. Adeyemi and O.V. Akinwande
  Dearth of empirical evidence to support medicinal claims of several herbal mixtures fuels growing safety concerns among the research community. Currently, there are no scientific data on Fijk herbal mixture even though it enjoys wide patronage in Nigeria. This study was done to evaluate biochemical indices and renal morphology following oral and repeated exposure to Fijk herbal. Twenty-four male Wistar rats of weight between 195-210 g were randomly distributed into four groups. Group 1 served as control and received distilled water only. Groups 2-4 received oral administration of Fijk herbal at 15, 30 and 45 mg kg-1, respectively. The treatment was daily and lasted for 21 days, after which the animals were sacrificed under anesthesia. The blood and kidney tissues were collected and used for the biochemical determinations and histopathology examination. Exposure to Fijk herbal in rats caused elevated levels of plasma creatinine and urea relative to the control. Likewise, levels of rat plasma potassium and sodium increased following oral exposure to Fijk herbal. In contrast, the rat kidney weights as well as organ-to-body weight ratio were significantly decreased due to Fijk herbal exposure. The histopathology examinations revealed inflammation, swollen renal tubules and necrosis in groups exposed to Fijk herbal. Oral and repeated exposure to Fijk herbal elevated rat biochemical indices and caused cellular lesion reminiscent of renal injury.
  O.S. Adeyemi , M.A. Akanji and J.T. Ekanem
  Anaemia has been shown to be a cardinal feature in African trypanosomosis. This study evaluated the effects of the ethanolic extract of Psidium guajava leaf on some haematological indices in rats experimentally infected with Trypanosoma brucei brucei. Observations revealed significant (p<0.05) decreases in the values for Packed Cell Volume (PCV), Haemoglobin (Hb), Red Blood Cell (RBC) counts, Mean Corpuscular Volume (MCV), Mean Concentration Haemoglobin Count (MCHC) in infected group relative to the treated as well as the uninfected animals. There was a significant (p<0.05) increase in the White Blood Cell (WBC) counts in infected animals when compared with the infected but treated animals. Also significant changes were observed for neutrophil in the infected animals compared to control and infected but treated groups (p<0.05). However, treatment with the ethanolic extract was able to significantly (p<0.05) improve the PCV, Hb, RBC, MCV, MCHC and neutrophil levels relative to the infected but untreated animals. Results demonstrate the anti-anaemic properties of the ethanolic extract of P. guajava in rats infected with T.b. brucei.
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