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Articles by O.P. Ajagbonna
Total Records ( 2 ) for O.P. Ajagbonna
  S.A. Habibullah , L.S. Bilbis , M.J. Ladan , O.P. Ajagbonna and Y. Saidu
  Reducing cholesterol content of table egg may be important in curbing the risks of atherosclerosis. In this study, forty, (32 week old) Shika Brown laying hens were randomly distributed into five groups to investigate the effect of aqueous extract of Hibiscus sabdariffa calyces on serum lipid profile and egg yolk cholesterol. Groups 2 - 5 received 1, 2, 4 or 8 g L-1 solution of the extract. Group 1 (control) received tap water. All the animals were fed ad libitum with layers mash for twelve weeks. Blood samples and eggs were collected after every three weeks and sera and egg yolk were analyzed for total cholesterol, triglycerides (TAG), high-density lipoprotein cholesterol (HDL-C) and egg yolk cholesterol respectively. Hibiscus sabdariffa extract caused a significant (p<0.05) non dose dependent increase in serum total cholesterol and egg yolk cholesterol but significant (p<0.05) dose-dependent decrease in serum TAG and HDL-C content. No strong correlation (0.2273) was found between serum and yolk total cholesterol. These results suggest that aqueous extract of Hibiscus sabdariffa may possess hypotriglyceridemic effect in Shika Brown laying hens but caused increase in serum and egg yolk cholesterol.
  E.U. Etuk , V. Igbokwe , O.P. Ajagbonna and M.O. Egua
  There have been earlier reports of herbal medicine toxicity elsewhere in Nigeria, China and India. The present study examined the possible acute and subchronic toxic effects of Nasara Pile Syrup (NPS), a Nigerian commercial polyherbal medicine in albino rats. Graded doses (0.5, 1.0, 1.5 and 1.75 mL/100 g) of the herbal medicine were administered to 4 groups of albino rats and their responses observed for 72 h to study the acute toxic effect of the herbal medicine. In the subchronic toxicity study, the rats were treated orally with repeated doses of the extract for 28 days after which the animals were slaughtered and samples from the liver, kidney and heart obtained for histopathological examination. The results showed that, administration of a single dose of the herbal medicine did not produce any harmful effect or death in the animals. But in the repeated dose treatment, the herbal medicine produced a number of deaths and damages on the kidney, liver and heart of the rats that were evidenced by histopathological lesions in a dose dependent manner. Based on the results, it was concluded that, prolong administration of NPS may cause harmful effect in the consumers, therefore, the general public should exercise caution in taking this herbal remedy and they should be aware of the impending health risk that may be associated with it.
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