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Articles by O.O. Oyebanji
Total Records ( 1 ) for O.O. Oyebanji
  A.M. Akingbade , L.C. Saalu , O.O. Oyebanji , D.A. Oyeniran , O.O. Akande and G.G. Akunna
  This study evaluates the testicular degeneration induced by Rhodinol-based incense using testicular histology, sperm characteristics, as well as testicular oxidative status bio-markers. Twenty four male adult albino rats (10-12 weeks old) weighing 200-230 g were divided into four groups (A, B, C and D) of six rats each. Group A served as the control group and the animals in this group were exposed to 1 g of natural solid air freshner. Groups B, C and D, were exposed to 1, 2 and 3 g of rhodinol-based incense smoke, respectively for 30-40 min every day for 62 days. All the exposures were via whole body inhalation. The animals were sacrificed 24 h after. The results obtained from this study showed a significant (p<0.05) decrease in the gross anatomical parameters of absolute and relative testicular weights in rats exposed to 2 g and 3 g rhodinol based incense when compared to the control group. The rhodinol-based incense exposed groups of rats also demonstrated a reduction of basal seminiferous epithelia, testicular atrophy, germinal aplasia and hypo-spermatozoa formation. Furthermore, there was a statistically significant (p<0.05) decrease in sperm count, sperm motility, normal sperm morphology and a significant (p<0.05) increase in total abnormal sperm morphology in group of animals exposed to 2 and 3 g rhodinol-based incense when compared to the control group. In addition, groups of animals exposed to 2 and 3 g rhodinol-based incense demonstrated a derangement in their oxidative status when compared to the control group as evidence by the significant (p<0.05) decreased in activities of superoxide peroxidase, catalase, glutathione, reduced glutathione and significant (p<0.05) increase malondialdehyde (a product of lipid perioxidation). Taken together, it was concluded that rhodinol-based incense produces testicular derangement in testicular histology, sperm parameters and oxidative status in albino rats. This derangement may be mediated at least in part through the oxidative pathway.
 
 
 
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