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Articles by O.O. Okedeyi
Total Records ( 2 ) for O.O. Okedeyi
  S.A. Adeola , O.S. Folorunso , O.O. Okedeyi , B.F. Ogungbe , O.B. Babatimehin and O.Z. Thanni
  The emergence of antibiotic resistant bacteria has made the treatments of pathogenic infections difficult. The discovery that some analytes of plant extracts are active against multi-drug resistant bacteria has opened ways to researching into the antimicrobial activity of these phytocomponents. Studies are designed to determine the antimicrobial and antioxidant potentials of the volatile oil of Ocimum gratissimum and its inhibition on partially purified and characterized extracellular protease of Salmonella enteritidis. The oil was extracted by hydrodistillation. Its antimicrobial effect was carried out using microdilution method while antioxidant effect was tested against 1,1-diphenyl-2-picrylhydrazyl (DPPH). The caseinolytic activity of the enzyme was studied with oil as inhibitor. The enzyme was partially purified with dialysis and gel filtration. The oil has scavenging activity of 66.98±1.78% compared to butylated hydroxyltoluene (positive control), 53.29±2.51% (sig. p<0.0001) against DPPH. Salmonella enteritidis was inhibited by this oil with IC50 of 3.98% (v/v). The enzyme had optimal activities at 45°C and pH 7.5. None of the metallic chloride tested produced any significant increase in the activity of the enzyme. Hg2+ and Pb2+ were inhibitors of this enzyme. The oil showed a non-competitive inhibition with Km = 0.33 mg mL-1, Vmax = 1.25x103 μmol min-1 (oil absent) and V’max = 2.50x102 μmol min-1 (oil present). The highest purification fold = 1.88 and the highest percentage yield = 51.74 as compared to the crude enzyme extract. Therefore, the volatile oil of Ocimum gratissimum possessed antimicrobial and antioxidant activities, its inhibition against this protease may be one of the ways of its antimicrobial effect.
  J.O. Olowoyo , S.T.R. Mdakane and O.O. Okedeyi
  The persistent problem of water scarcity with the ever increasing demand of water has necessitated the reuse of effluent in agriculture. The present study evaluated the reuse of treated waste water and bioaccumulation properties of two fish species from a manmade lake. Trace metals content of two fish species: Clarias gariepinus and Cyprinus carpio and levels of trace metals from waste water in the lake where the fish species were harvested were determined by Inductive Couple Plasma-Optical Emission Spectrometer (ICP-OES). The trace metal values from fish samples ranged between 0.45-4.41 μg g-1 for Cu, 16.45-72.23 μg g-1 for Zn, 1.92-4.71 μg g-1 for Cr, 2.45-5.65 μg g-1 for Ni, 10.23-44.31 μg g-1 for Mn, 9.67-46.59 μg g-1 for Fe and 0.12-0.56 μg g-1 for Pb. The carp exhibited a significantly higher concentration for the trace metals for all the parts analyzed (p<0.01). The levels of trace metals concentration from Cyprinus carpio was in the order liver>gill>muscle>bone and metal accumulation was in the order Zn>Fe>Mn>Cr>Ni >Cu>Pb. The concentration of trace metals such as zinc, iron, chromium and nickel were higher than the recommended legal limits for human consumption. The result revealed that properly treated waste water could be used for the purpose of aquaculture. Clarias gariepinus bio accumulated more trace metals from the lake when compared with Cyprinus carpio.
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