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Articles by O.O. Olorunsogo
Total Records ( 1 ) for O.O. Olorunsogo
  O.A. Ogunbayo , R.A. Adisa , O.G. Ademowo and O.O. Olorunsogo
  The effect of single dose chloroquine treatment on enzymatic antioxidant profiles and lipid peroxidation in the blood of rabbits was investigated. Treatment of rabbits with 10 mg kg-1 (single dose) chloroquine resulted in increases of 53.6, 11.6 and 3.6% (p<0.05) in the activity of superoxide dismutase at 6, 12 and 24 h, respectively after drug administration while the activity of catalase was significantly reduced by 37.1, 15.5 and 2.9% (p<0.05) at the same intervals when compared with control. Malondialdehyde level increased (p<0.05) by 11.9 and 1.9% at 6 and 12 h, respectively, but decreased by 13.8% at 24 h relative to control. Reduced glutathione was decreased by 41.9, 38.7 and 3.2% at the same hourly intervals when compared with control (p<0.05). The findings in this study suggest that chloroquine treatment altered enzymatic antioxidant defense systems and elevated lipid peroxidation in the blood of rabbits with the most noticeable alteration observed 6 h after drug administration perhaps due to the peak plasma concentration of chloroquine which is usually reached between 3 and 5 h after drug administration. Oxidative stress is thus induced in the blood by chloroquine at least within 6 h of its administration.
 
 
 
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