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Articles by O.M. Ahmed
Total Records ( 3 ) for O.M. Ahmed
  O.M. Ahmed , R.G. Ahmed , M.M.S. Nada and M. Bahgat
  Because the heat stress is one of the most stressful factors on the biological systems, it was important to study its effect on the development of neurons in different Central Nervous System (CNS) regions of albino rat newborns. Development of neurons in cerebral cortex, cerebellar cortex and cervical and lumbar regions of the spinal cord was followed by using Golgi-copsch stain between days 7 and 21 after birth. The present study does not only illustrate the aspects of development processes of normal neurons in different regions of CNS, but also records the effects of heat stress (40±1°C) on them. The present study revealed that the development of the CNS is extremely sensitive to heat stress which led, in turn, to some harmful effects on the neurons development and caused delay of the dendritic arborization in all investigated CNS regions of the rat newborns. Taken together, further studies are required to determine if the beneficial effects of heat exposure result in changes of stress complications only or not. Thus, experiments will be required to solve these problems and to comprehend the actual role of heatstroke in neurodegeneration of CNS.
  O.M. Ahmed
  The purpose of this study was to assess the effects of vasoactive intestinal peptide (VIP) administration on the glycemic state, insulin secretion, various pro-inflammatory and anti-inflammatory cytokines, liver pathology and oxidative stress as well as antioxidant defense system in streptozotocin-induced diabetic mice. VIP was intraperitoneally administered to normal and streptozotocin-induced diabetic CD1 mice at a dose level of 41.6 ng kg-1 b.wt., 3 times/week for 8 consecutive weeks to form a total dose of 1 μg kg-1 b.wt. at the end of the experiment. The VIP was found to have anti-hyperglycemic and insulinotropic properties and improving effects on the islets of Langerhans and liver pathology of diabetic mice. These VIP ameliorating-changes may be mediated via its augmenting effect on anti-inflammatory cytokines (IL-10 and IL-12) and decreasing effect on pro-inflammatory cytokine, TNF-α, as well as its potency in suppressing the oxidative stress and enhancing the anti-oxidant defense system. However, further clinical studies are required to assess the efficacy and safety of VIP in diabetic human beings.
  O.M. Ahmed
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