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Articles by O.L. Adebayo
Total Records ( 3 ) for O.L. Adebayo
  B.A Salau , A.O. Ketiku , O.L. Adebayo , W.E. Olooto , E.O. Ajani and O. Osilesi
  The involvement of sucrose and its amount in the causation of cardiovascular disease is still controversial and inconclusive. The two latest reports of WHO/FAO and Institute of Medicine of Food and Nutritional Board (IOM of FNB) on optimal level of sucrose consumption are at least contradictory; therefore the need to clarify the effect of different concentrations of sucrose consumption on cardiovascular disease risk factor is expedient. Effect of sucrose consumption was assessed on twenty four male albino rats, four to six weeks old, 48-65 g, divided into five groups: G1 (control), G2 (10% energy supply from sucrose), G3 (20% energy supply from sucrose), G4 (30% energy supply from sucrose). The following parameters were determined: red blood cell count, white blood cell count, packed cell volume, blood and plasma viscosities; fibrinogen level and erythrocyte sedimentation rate. Analyses revealed that inclusion of sucrose at concentration of 20% energy supply significantly increased (p<0.05) blood viscosity by 97.59%, plasma viscosity 16.48%, erythrocyte sedimentation rate 40.00%, plasma fibrinogen13.63% and white blood cell count 6.59%, while no significant effect (p>0.05) was observed on red blood cell count and packed cell volume. The study revealed that consumption of sucrose at twenty percent energy supply increased some selected haematological and haemorrheological parameters associated with cardiovascular disease.
  O.L. Adebayo , B. O. Adegbesan and G. A. Adenuga
  The comparative effect of Protein-Undernutrition (PU) and well-known neurotoxins on brain weight, lipid peroxidation and cellular antioxidants were investigated. The animals were randomly assigned to ten groups: A, B, C, D, E, F, G, H, I and J with five rats per group. Group A were placed on 16% casein diet while group B were placed on low protein diet (5% casein). Animals in groups C, E, G and I, received 200 ppm KCN, 80 mg (kg b.wt.)-1 PB, 75 mg (kg b.wt.)-1 DDT and 100 μ mole (Kg b.wt.)-1 Pb(NO3)2, respectively while groups D, F, H and J, served as their respective controls. Results show that KCN induced significant reduction in brain weight and SOD activity and significant increase (p<0.05) in CAT but no effect was observed in Lipid Peroxidation (LP) and GSH. DDT induced significant reduction (p<0.05) in CAT activity but did not affect other parameters investigated. Pb(NO3)2, however, caused significant increase in LP and GSH and significant reduction (p<0.05) in brain weight but has no effect on the antioxidants. PB induced significant reduction in brain weight and significant increase (p<0.05) in LP, CAT and GSH whereas it has no effect on SOD. PU induced significant reduction in brain weight and CAT while it induced significant increase (p<0.05) in LP but has no effect on GSH level. In conclusion, these results have demonstrated that PU and all the chemical neurotoxins investigated in this study except DDT induced brain damage (measured as reduced brain weight) in some cases as a consequence of oxidative stress and in some other cases by some unknown mechanisms. PU like some of these chemical neurotoxins induced brain damage presumably as a consequence of oxidative stress.
  B.A. Salau , W.E. Olooto , O.L. Adebayo , E.O. Ajani , K.T. Odufuwa and J.O. Olowookere
  Effects of various concentrations of sucrose diet were assessed on thirty weaning male albino rats divided randomly into five equal groups as follows: G1 (baseline group); G2 (control group given rat chow only); G3, G4 and G5 (groups with energy supply from sucrose at 10, 20 and 30%, respectively). The four groups were fed for twelve weeks and then fasted overnight. They were then anaesthetized with diethyl ether and venous blood was collected using cardio puncture method. Plasma was collected by centrifugation and total plasma cholesterol, HDL cholesterol and serum Triglycerides were assayed using Randox enzymatic kit while VLDL cholesterol, LDL cholesterol, Atherogenic index and coronary risk indices were calculated. Sucrose diet increased energy density. It also increased significantly (p<0.05). Plasma total cholesterol, LDL cholesterol, VLDL cholesterol, Triglycerides, Atherogenic and Coronary risk indices while it decreased HDL cholesterol. Present results indicated that sucrose diet at present level of consumption (about 25% energy supply) elevated cardiovascular risk factors in male albino rats and may predispose one to cardiovascular diseases.
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