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Articles by O.I. Iribhogbe
Total Records ( 7 ) for O.I. Iribhogbe
  O.I. Iribhogbe , U. Akpamu , J.E. Emordi , A. Aigbiremolen , E.O. Nwoke and B. Idinoje
  The effect on electrolyte profile following oral administration of antioxidants (vitamin A, C and E supplements in early pregnancy was investigated using albino rats of the Wistar strain. Eighty-five female rats weighing between 255-300 g were used for the study. They were randomly assigned to three study groups having 5 sub groups with five animals each, a control and vehicle group with five animals each. After pregnancy has been confirmed, the control group was administered 1 mL of distilled water, vehicle group 1 mL of tween 80, while test groups 1, II and III received different doses of vitamin A, C and E, respectively via the intragastric route for 11 days. The administration of vitamin A, C and E in early pregnancy for 11 days produced insignificant changes in serum Na+ levels (p>0.05) and a significant increase in serum Ca2+ level. With the exception of vitamin C, vitamin A and E produce a significant increase in serum K+ and Cl¯ levels. Conclusively administration of vitamin A, C and E in early pregnancy cause no significant alteration in serum Na+ levels. However, care must be taken when vitamin A and E are administered with agents that elevate serum Ca2+ and K+ levels as this may pontentiate hypercalcemia and hyperkalemia, respectively in early pregnancy.
  O.I. Iribhogbe , A. Aigbiremolen , U. Akpamu , J.E. Emordi and E.O. Nwoke
  The purpose of this study is to evaluate the effects of vitamin A, C and E supplementation on lipid profile in early pregnancy. A total of 85 adult female wistar albino rats weighting 225-300 g were used and randomly grouped into 5 groups (2 control groups of five rats each, 3 test groups with 5 sub- groups of 5 rats each). After, pregnancy was confirmed, the control groups were administered distilled water and tween 80 respectively, while test groups A, C and E received vitamin A, C and E supplements, respectively. At the end of the 11th day of the experiment, blood samples were collected and TC (total cholesterol), TG (Triglyceride), LDL-C (low density lipoprotein cholesterol and HDL-C (high density lipoprotein cholesterol) were assayed using standard procedure. The test group had significantly increased TC, LDL- C and HDL- C but decreased TG levels following vitamin A administration when compared with control (p<0.05). The group supplemented with vitamin C also had significantly higher TC, TG and LDL- C and unchanged HDL-C compared with control (p<0.05). The group supplemented with vitamin E had a non significant TC levels, a significantly increased TG and HDL- C and a significantly reduced LDL- C levels (p<0.05). Based on results observed, we suggest that, in pregnancy, dietary supplementation with Vitamin A and E may be cardioprotective. This is because vitamin A and E significantly increase HDL- C, although this is accompanied by increase of other serum lipid component. Vitamin C, however was not beneficial.
  O.I. Iribhogbe , J.E. Emordi , E.O. Nwoke , B.O. Idonije and U. Akpamu
  The purpose of this present study is to determine the influence of varying combinations of antioxidant Vitamins on the hyper-hepatic state of pregnancy. To achieve this, seventy pregnant Wister albino rats weighing between 250-300 g were procured and grouped into 2 control groups treated with distilled water and vehicle- tween-80, respectively and three cohorts (I, II and III) with four sub-groups each (n = 5). Starting from the 7th day, group I received a varying dose combination of Vitamin A+C, group II Vitamin A+E and group III Vitamin C+E respectively for 11 days. Results of liver function assay revealed that supplementation with Vitamin A+C, A+E and C+E caused a significant reduction (p<0.05) in serum protein and a non-significant (p>0.05) alteration in serum albumin. Except for ALT where Vitamin A+E combination produced no significant alteration, serum AST (Aspartate transaminase) and ALP (Alanine transaminase) were significantly reduced (p<0.05) with antioxidant Vitamin combination therapy when compared with control. Antioxidant vitamin combination may be advantageous in pregnancy induced hyper- hepatic state. However, further study is needed in this respect.
  O.B. Idonije , O.O. Festus , U. Akpamu , O. Okhiai , O.I. Iribhogbe and G.B.S. Iyalomhe
  Although antipsychotic drugs are known to have an array of adverse effects, they also exhibit significant differences in causing these effects. The atherogenic effects of clozapine and risperidone have not been fully investigated among schizophrenics in Nigeria hence this research work. This study therefore investigated the extent to which monotherapy with clozapine and risperidone (atypical antipsychotic drugs) influence lipid profile in patients with schizophrenia. The study population comprised 29 Schizophrenic patients from Psychiatric Hospital, Uselu, Benin city, Nigeria. They were placed on typical antipsychotics for six weeks: 10 patients were on risperidone (1-4 mg day-1 in divided doses) and 19 patients were on clozapine (25-300 mg day-1 in divided doses). The control group comprised 30 apparently healthy volunteers. Blood samples were collected from all subjects on the first day before the commencement of treatment with antipsychotic drug and 24 h after the last administration of antipsychotics at the end of week 6 for analyses of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL) and very low density Lipoprotein cholesterol (VLDL) using standard methods. Comparing with the control, the basal serum TC, TG, LDL and VLDL of the clozapine treated group were not significantly different except for HDL which was significantly reduced and the atherogenic indices (TC/HDL and LDL/HDL) which were significantly increased. However the risperidone treatment group showed significantly higher TC, TG, LDL and VLDL levels while HDL was significantly reduced. At the end of week 6, there was significant increase in serum TC, TG, HDL and VLDL and a significant decrease in HDL in both treatment groups compared to the control except VLDL that was not significantly different in the clozapine group. Comparing the two treatment groups, risperidone caused a more significant increase on lipid profile and atherogenic indeces than clozapine. This effect was about two times or greater with risperidone than clozapine. Conclusively, additional prospective clinical trials are required to support a specific therapeutic approach for managing dyslipidaemia that are present in clozapine and risperidone treated schizophrenic patients in an attempt to avoid its consequent adverse effects.
  O.I. Iribhogbe , E.O. Agbaje , I.A. Oreagba , O.O. Aina and A.D. Ota
  Micronutrients are known to have antioxidant activity; however, its role in plasmodial infection is still not clearly defined. The present study involves an in vivo evaluation of the role of some selected antioxidant micronutrients in the therapeutics of malaria. In this study, rodent malaria model using Plasmodium berghei NK-65 strain (chloroquine sensitive) was used. Fourty five mice of either sex weighing 20.05±0.02 g were used for the study. Fourty mice were inoculated intraperitoneally with 1x107 million Plasmodium berghei infected erythrocyte and were administered with 0.2 mL of distilled water, 0.2 mL of vehicle; Tween 80 (control and vehicle group), chloroquine 25 mg kg-1 and artesunate 4 mg kg-1 (standard drug group), vitamin A 60 mg kg-1, vitamin E 100 mg kg-1, selenium 1 mg kg-1, zinc 100 mg kg-1 (test group F, G, H and I, respectively) 72 h post inoculation. Antioxidant micronutrients demonstrated significant (p<0.05) chemosuppressive activity when compared with negative control during the 4 day curative test. Mean parasitemia was significantly reduced (p<0.05) in the micronutrient treated groups after the 4 day curative test when compared with negative control. This however, was also significant between micronutrient treated groups (F = 17.88; p = <0.05). Catalase and glutathione peroxidase activity was significantly (p<0.05) higher in the vitamin A, E, selenium and zinc treated groups, respectively when compared to apparently healthy uninfected control. Conclusively, antioxidant micronutrients have antimalarial activity and may be of benefit in malaria therapeutics.
  O.I. Iribhogbe , E.O. Agbaje , I.A. Oreagba , O.O. Ain and A.D. Ota
  Malaria infection has been associated with a decrease in hematological parameters. This is linked to micronutrient deficiency which is associated with increasing severity of infection. The present study involves an in vivo evaluation of the role of some selected antioxidant micronutrients in the modulation of hematological profile in malaria infection. Rodent malaria model using Plasmodium berghei NK-65 strain (chloroquine sensitive) was used. A 4 day curative test was conducted using 45 mice of either sex with a mean weight of 20.05±0.02 g. Fourty mice were inoculated intraperitoneally with 1x107 million Plasmodium berghei infected erythrocyte and were administered with 0.2 mL of distilled water, 0.2 mL of vehicle; Tween 80 (control and vehicle group), chloroquine 25 mg kg-1 and artesunate 4 mg kg-1 (standard drug group), vitamin A 60 mg kg-1, vitamin E 100 mg kg-1, selenium 1 mg kg-1, zinc 100 mg kg-1 (test group F, G, H and I, respectively) 72 h post inoculation. Results showed a statistically (p<0.05) significant difference in total White Blood Cell count (WBC) in the vitamin A, E, selenium and zinc treated groups when compared with apparently healthy non-inoculated control. Additionally, there was a significant increase in MCHC in the zinc treated group when compared to apparently healthy uninfected control (34.21±0.29 g dL-1 versus 31.88±0.63 g dL-1; p<0.05). In conclusion, use of antioxidant micronutrients as adjuvant may help improve hematological parameters in malaria induced anemia in addition to modulating cell mediated immune response.
  O.I. Iribhogbe , E.O. Agbaje , I.A. Oreagba , O.O. Aina and A.D. Ota
  Free radical production from oxidative stress induced by malaria infection plays a major role in the pathogenesis of malaria. However, the use of agents with antioxidant activity may interfere with malaria progression. The study involves an in vivo evaluation of the role of some antioxidant micronutrients in the modulation of malaria infection. Rodent malaria model using Plasmodium berghei NK-65 strain (chloroquine sensitive) was used for the study. Fourty five mice of either sex weighing 20.05±0.02 g were procured for the study. Fourty mice were inoculated intraperitoneally with 1x107 million Plasmodium berghei infected erythrocyte and were administered with 0.2 mL of distilled water, 0.2 mL of vehicle; Tween 80 (control and vehicle group), chloroquine 25 mg kg-1 and artesunate 4 mg kg-1 (standard drug group), vitamin A 60 mg kg-1, vitamin E 100 mg kg-1, selenium 1 mg kg-1, zinc 100 mg kg-1 (test group F, G, H and I, respectively) 72 hours post inoculation. Antioxidant micronutrients demonstrated significant (p<0.05) schizonticidal activity when compared with negative control during the 4 day curative test. Erythrocyte membrane distability was most markedly elevated in the tween 80 group (426.15%), followed closely by the chloroquine (373.85%) treated group and artesunate group (329.23%) and least in the zinc treated group (32.31%). There was no significant (p>0.05) difference in MCFI values (0.115±0.002; 0.114±0.002 g dL-1) between vitamin A treated group and selenium treated group respectively. However, this was significant (p<0.05) between the micronutrient treated groups and the control (negative, positive and vehicle). Conclusively, antioxidant micronutrients have antimalarial activity which may be due potentiation of erythrocyte membrane stabilization.
 
 
 
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