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Articles by O.G. Nacoulma
Total Records ( 10 ) for O.G. Nacoulma
  J. Sakande , E. Kabre , M. Lompo , E. Pale , J.B. Nikiema , O.G. Nacoulma , M. Sawadogo and I.P. Guissou
  In previous studies, using a bioassay-guided fractionation procedure; five fractions (E1F1, E2F2, E3F3, E4F4 and E5F5) from powdered Borassus aethiopum male inflorescences were extracted. Among these, the dichloromethane methanol extract E2F2 was found to exert significant anti-inflammatory and antipyretic activities and pro apoptotic effect. It seemed important to pursue the investigations to understand the mechanism of the anti-inflammatory activity. The anti-inflammatory activity was studied, C Reactive Protein (CRP) level in mice blood was immunoturbidimetry after inflammation induction and antioxidant activity was studied using 1,1 diphenyl picrylhydrazyl (DPPH). Phytochemical screening was carried out according to the methodology for chemical analysis for vegetable drugs. Among 3 fractions (I1; I2, I3) of E2F2, I1 was the most active with a percentage of inhibition (PI) of 80%. This anti-inflammatory activity was twice high than indometacin (PI = 40%). The I1 fraction cause significant decline of concentration of CRP compared with indometacin. The radical scavenging activities of I1 were approximately 4 times lower than ascorbic acid. Phytochemical analyses of Borassus aethiopum extracts revealed the presence of terpenoids, steroids and saponins which all have been shown to be potent anti-inflammatory and antioxidants. The present study confirmed the anti-inflammatory and antioxidant potential of Borassus aethiopum extracts with results comparable with those of standard compounds such as indometacin. Further studies are needed to isolate, purify and identify the chemical structure of the compounds responsible for anti-inflammatory and antioxidant activity.
  K. Konate , A. Souza , M. Lamidi , J.F. Djoba Siawaya , F.H. Ella Mendene , J. Millogo-Rasolodimby and O.G. Nacoulma
  Cienfuegosia digitata Cav., one specie of family of Malvaceae and a herbal plant well known in traditional medicine in Burkina Faso to treat infectious disease particularly hepatitis B. The present study was conducted to evaluate the biological and toxic effects of aqueous acetone extract of Cienfuegosia digitata Cav. in mice Swiss and albinos Wistar rats. In acute toxicity test, mice received doses of this extract by intraperitoneal route with LD50 value of 601.8 mg kg-1. In sub-acute toxicity test, albinos Wistar rats were treat by gavage during 28 days with different doses of aqueous acetone extract of Cienfuegosia digitata Cav. (25, 50, 100 mg kg-1). In biological parameters evaluations, the results varied widely in dose of extract and weight of rats and did not show clinical correlations. We undertook this study of extract in order to provide a scientific basis for the traditional use of Cienfuegosia digitata Cav. in traditional medicine. Present results of this study appeared to show the safety of acute and sub-acute toxicities of extract from of Cienfuegosia digitata Cav. which can therefore be continuously used with safety in traditional medicine. Statistical studies revealed that there is a low significant difference in body and organ weights and biological parameters between control group and the treated assay groups (p<0.01 or p<0.05).
  P.A.E.D. Sombie , A. Hilou , A.Y. Coulibaly , A. Tibiri , M. Kiendrebeogo and O.G. Nacoulma
  The purpose of the present study was to investigate the protective effects of the extracts against H2O2-induced hemolysis of erythrocytes and the neuroprotective potential from galls of Guiera senegalensis. Ethyl acetate fraction of aqueous decoction extract (EAF/ADE) significantly (p<0.05) inhibited lipid peroxidation in rat’s brain homogenate in vitro (37.79±0.93% at 1.25 mg mL-1) when compared to the gallic acid and quercetin used as positive controls and has the best anti-acetylcholinesterase activity (64.02±4.07% at 100 μg mL-1). Under the oxidative action of H2O2, the extracts from galls of G. senegalensis showed significant protection of the erythrocyte membrane from hemolysis. The Aqueous Decoction Extract (ADE) contains the highest amount of total tannin (25.3±1.55 mg TAE/100 mg of extract) content. The erythrocytes hemolysis inhibitory property from galls of G. senegalensis seems to be related weakly to its total tannin content (p<0.05). The present study thus suggested that the galls from G. senegalensis could be used as a new potential source of natural neuro-protective and antioxidant components.
  S. Bakasso , A. Lamien-Meda , C.E. Lamien , M. Kiendrebeogo , J. Millogo , A.G. Ouedraogo and O.G. Nacoulma
  Aqueous acetone extracts prepared from five Indigofera species of Burkina Faso, namely Indigofera colutea (Burm.) Murril., I. macrocalyx Guilld et Perr., I. nigritana Hook f., I. pulchra willd. and I. tinctoria L., were investigated for their phytochemical composition and their antioxidant activities. Standard methods and TLC were used to screen the phytochemical composition. The total phenolic and flavonoid content of extracts were assessed by Folin-Ciocalteu and AlCl3 methods, respectively. These extracts were also evaluated for their antioxidant potentials using ferric reducing antioxidant power (FRAP), 2,2-diphenyl-l-picrylhydrazyl (DPPH) and 2,2`-azinobis(3-ethylbenzothiazoline-6-sulphonate) (ABTS) assays. Flavonoids, saponins, quinones, sterols/triterpenes and tannins were present in all these species except for I. pulchra where quinones were not found. Gallic acid, caffeic acid, rutin and myricetin in I. colutea; gallic acid, quercitrin, myricetin in I. tinctoria; galangin and myricetin in I. macrocalyx were identified by thin layer chromatography. Among these, I. colutea, I. tinctoria, I. nigritana and I. macrocalyx, which had the highest phenolic content, were also found to possess the best antioxidant activities. The results indicated a good correlation between antioxidant activities and total phenolic content (p<0.05 for FRAP/DPPH and DPPH/ABTS and p<0.01 for FRAP/ABTS). These plants represent promising sources of natural antioxidants and these findings give scientific bases to their ethnopharmacological uses.
  T.H. Coulidiati , H. Millogo-Kone , A. Lamien-Meda , C.E. Lamien , M. Lompo , M. Kiendrebeogo , S. Bakasso , M. Yougbare-Ziebrou , J. Millogo-Rasolodimby and O.G. Nacoulma
  In this study, the antioxidant and antibacterial activities of acetone extract, ethyl acetate, n-butanol and n-hexane fractions of acetone extract from leaves of Combretum nioroense Aubrév. ex Keay were investigated. The total phenolics and total flavonoids contents in the fractions and acetone extract were determined by spectrophotometric methods using Folin-Ciocalteu and AlCl3, respectively. Two methods were adopted to assess the antioxidant activities: the Ferric Reducing Antioxidant Power (FRAP) and the radical scavenging activity of 2, 2’-azinobis (3-ethylbenzothiozoline-6-sulfonate) radical cation (ABTS). The Minimum Inhibitory Concentrations (MICs) of the extract and fractions against pathogenic bacteria (4) and serotyped bacteria (4) from American Type Culture Collection (ATCC) were also determined using the agar-well diffusion method. The results showed that the butanol fraction, with the highest phenolic content, exhibited the best antioxidant and antibacterial activities as compared to the ethyl acetate fraction which contains more flavonoids.
  N.T.R. Meda , A. Lamien-Meda , M. Kiendrebeogo , C.E. Lamien , A.Y. Coulibaly , J. Millogo-Rasolodimby and O.G. Nacoulma
  The present study aimed to test the validity of Balanites aegyptiaca remedies used for the treatment of rheumatisms and mental disorders by examining the antioxidant, xanthine oxidase and acetylcholinesterase inhibitory activities of galls and leaves extracts and fractions. The total phenolics and flavonoids were measured using Folin-Ciocalteu and AlCl3 reagents, respectively. Two methods i.e., FRAP and ABTS were used to estimate the total antioxidant capacity of the plant materials. The FRAP and ABTS antioxidant activities showed that among all extracts and fractions tested, the best antioxidant activities were found with the galls dichloromethane and the leaves ethyl acetate fractions. The antioxidant activities did correlated significantly with the total phenolic and flavonoid contents. The study also showed that B. aegyptiaca galls and leaves fractions exhibited a moderate xanthine oxidase inhibitory activity comparatively to the acetylcholinesterase which was weakly inhibited by the tested extracts and fractions.
  K. Konate , A. Souza , A.Y. Coulibaly , N.T.R. Meda , M. Kiendrebeogo , A. Lamien-Meda , J. Millogo-Rasolodimby , M. Lamidi and O.G. Nacoulma
  In this study polyphenol content, antioxidant activity, lipoxygenase (LOX) and Xanthine Oxidase (XO) inhibitory effects of n-hexane, dichloromethane, ethyl acetate and n-butanol fractions of aqueous acetone extracts from S. alba L., S. acuta Burn f. and Cienfuegosia digitata Cav. were investigated. The total phenolics, flavonoids, flavonols and total tannins were determined by spectrophotometric methods using Folin-ciocalteu, AlCl3 reagents and tannic acid, respectively. The antioxidant potential was evaluated using three methods: inhibition of free radical 2,2-diphenyl-1-picrylhydramzyl (DPPH), ABTS radical cation decolorization assay and Iron (III) to iron (II) reduction activity (FRAP). For enzymatic activity, lipoxygenase and xanthine oxidase inhibitory activities were used. This study shows a relationship between polyphenol contents, antioxidant and enzymatic activities. Present results showed that ethyl acetate and dichloromethane fractions elicit the highest polyphenol content, antioxidant and enzymatic activities.
  J. Sakande , P. Rouet-benzineb , H. Devaud , J.B. Nikiema , M. Lompo , O.G. Nacoulma , I.P. Guissou and A. Bado
  Borassus aethiopum MART (Arecaceae) is a plant used in traditional herbal medicine for the treatment of various diseases (bronchitis, laryngitis, antiseptic). In particular, their male inflorescences were reported to exhibit cicatrizing, antiseptic and fungicidal properties. In the present study, the biological activity of E2F2, an apolar extract from Borassus aethiopum male inflorescence was investigated on colon cancer HT29 cells. Phytochemical screening was carried according to methodology for chemical analysis for vegetable drugs. Cells proliferation was determined by the MTT assay and cells cycle distribution was analysed by using laser flow cytometer (Beckman coulter). The cytoskeleton organisation was examined under a laser scanning confocal microscope (Zess). Preliminary phytochemical analysis of E2F2 extract revealed the presence of sterols, triterpenes and saponosids. E2F2 extract (1 μg and 100 μg mL-1) significantly inhibited cell proliferation by blocking cell population in G0/G1 phase. Flow Cytometric analysis of E2F2-treated HT29 cells showed that hypoploïd cell population (sub G1 phase) increased with processing time exposures. Immunofluorescence confocal analysis revealed a disrupt actin microfilaments network in E2F2 treated-cells with a significant reduction in actin stress fibres and appearance of a random, non-oriented distribution of focal adhesion sites. These data indicate that E2F2 extract has anti-proliferative and pro-apoptotic activities. Further studies are required to unravel the mechanisms of action of E2F2 extract.
  T.H. Coulidiati , H. Millogo-Kone , A. Lamien-Meda , M. Yougbare-Ziebrou , J. Millogo-Rasolodimby and O.G. Nacoulma
  The aim of this study was to determine the phytochemical content and to evaluate the antioxidant and antibacterial activities of the acetone extract from Combretum acutum Laws (leaves) and Combretum sericeum G. Don (aerial part). Acetone extracts were fractionated with n-hexane, ethyl acetate and butanol successively and their bioactivities were also evaluated. Phenolic, tannin and flavonoid contents have been determined using spectrophotometric methods. The antioxidant activity of these plant extracts and fractions has been determined by ABTS, FRAP and DPPH methods. The phytochemical screening revealed the presence of tannins, steroids/triterpenoids, saponins and cardenolides and different contents of flavonoids and anthraquinones in the acetone extracts of both plants. Results obtained from this study also showed that the butanol fractions, with the highest phenolic and tannin contents, exhibited the best antioxidant and antibacterial activities and will be maintained for further investigations. In addition to that, the Minimum Inhibitory Concentrations (MICs) of the extracts and fractions against pathogenic bacteria (5) and serotyped bacteria (5) from American Type Culture Collection (ATCC) were also determined using the agar-well diffusion method. Both plants possess good antioxidant and antibacterial activities.
  P.A.E.D. Sombie , A. Hilou , C. Mounier , A.Y. Coulibaly , M. Kiendrebeogo , J.F. Millogo and O.G. Nacoulma
  The galls of Guiera senegalensis J.F. Gmel (Combretaceae) are used in Burkina Faso traditional medicine to treat some microbial and metabolic diseases such as malaria, dysentery, diabetes and hypertension. The purpose of the present study was to investigate the phytochemical analysis, the antioxidant and anti-inflammatory inhibitory activities from the galls of Guiera Senegalensis. Phytochemical assay was conducted with following standard protocols. The method of DPPH, FRAP, β-carotene assay, anti-lipid peroxidation (according to the thiobarbituric acid method) studies in vitro were employed to assess the antioxidant efficacy. The xanthine oxidase and lipoxygenase inhibition properties of extracts and fractions were also evaluated to assess the anti-inflammatory activity from galls of Guiera senegalensis. Galls extracts of G senegalensis are rich in totals polyphenol and in totals flavonoid content. The hydroacetonic extract showed the most potent antioxidant activity in FRAP method (10.88±0.86 mmol AEAC g-1) and anti-lipid peroxidation activity (75.06±2.42%) at a concentration of 1.25 mg mL-1. The water fraction of hydroacetonic extract showed the most potent antioxidant activity (6.012±0.13 mmol AEAC g-1 ) in the DPPH radical scavenging method and butanol fraction of hydroacetonic extract in the β-carotene bleaching method (59.00±3.27%) at a concentration of 100 μg mL-1. The highest antioxidant activity can be positively correlated with the highest total phenolics content and also with the highest anti-inflammatory activity of the tested extract/fraction. The present study thus provides a scientific rationale for the traditional use of this plant product to the treatment of metabolic diseases.
 
 
 
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