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Articles by O.G. Arinola
Total Records ( 4 ) for O.G. Arinola
  O.G. Arinola , S.O. Badmos and O.G. Ademowo
  There are extensive literature on the adverse effects of malaria parasites on pregnancy outcomes, but the basis of this observation is un-conclusive. We investigated the effects of Plasmodium yoelii malaria on the levels of trace elements and total antioxidants in gravid BALB/c mice infected with Plasmodium yoelii at first (early), second (middle) and third (late) trimesters. The mice were grouped into, viz: Gravid mice infected at day 3-post plug (I3PP) representing 1st trimester, gravid mice infected at day 7 post plug (I7PP) representing 2nd trimester, gravid mice infected at day 11-post plug (I11PP) representing 3rd trimester, gravid not infected (GNI), infected non-gravid (ING) and non-gravid non-infected mice (NGNI). The highest % parasitemia was observed in the group of mice infected at 3rd trimester. None of the mice infected at 1st and 2nd trimesters carried the pregnancy to term. The % PCV was lowest in gravid mice infected in 1st trimester compared with other gravid infected mice. At day 5 and day 9 post infection, the levels of Mn, Mg, Zn, total antioxidants, Cu, Fe and Se were raised in all gravid infected mice compared with non-gravid non-infected mice. It may be concluded from this study that P. yoelii malaria is most severe in mice infected at the early stage of gravidity (1st trimester) and that raised levels of trace elements and anti-oxidants in P. yoelii infected pregnant mice could be a result of oxidative stress and free radical burden.
  O.G. Arinola
  Throughout the world 7% of individuals above 18 years of age are habitual consumers of alcoholic beverages, despite the fatal consequences of alcohol consumption on immune system and other organs. This study is designed to provide biochemical basis for the fatal consequences of alcohol consumption. The levels of metal binding proteins (transferrin, caeruloplasmin and alpha 2-macroglobulin) and essential trace elements (Zn, Cu, Mn, Fe and Se) were determined in male Nigerians that consume alcohol beverages compared with controls using immuno diffusion method and atomic absorption spectrophotometric method respectively. Transferrin and Zn were significantly reduced while Cu and Mn were significantly raised in alcohol consumers compared with the controls. No correlation was found between the levels of metal binding proteins and essential trace elements. Reduction of transferrin and Zn might explain susceptibility of alcohol consumers to infections and that Zn supplementation is recommended for alcohol consumers to boost their immunity.
  O.G. Arinola , J.A. Olaniyi and M.O. Akiibinu
  Homozygous sickle cell disease (genotype HbSS) confers a certain degree of protection to human (especially Africans) Plasmodium falciparum malaria, yet the precise mechanism remains unknown. Recent observations suggest that the mechanism might also involve immune and non-immune components. In this study, the plasma levels of trace elements (Mg, Fe, Zn, Mn, Cu, Cr, Cd and Se) and antioxidants (urea, albumin and total antioxidants) were determined in Nigerians with sickle cell disease with (HbSS+M), or without (HbSS-M) Plasmodium parasitaemia, haemoglobin AA with Plasmodium parasitaemia (HbAA+M) compared with those having haemoglobin AA without Plasmodium parasitaemia (HbAA-M) using spectrophotometric method. The mean level of urea was significantly higher while the total antioxidants (TAS), Mg, Fe, Zn, Mn, Cu, Cr, Cd, Se and albumin were not significantly different in HbAA+M subjects when compared with HbAA-M subjects. In HbSS-M subjects, the levels of Fe, Zn, Mn and TAS were significantly lower while the level of urea was significantly higher when compared with HbSS+M subjects. There were no significant differences in the values of Mg, Cu, Cd, Se and albumin in HbSS-M subjects when compared with HbAA-M. In HbSS+M subjects, significantly lower levels of Fe, Zn, Mn, Cu, Cr, Cd, Se, total antioxidants, but significantly higher level of urea were observed when compared with the HbAA-M subjects. The result of this study revealed an aggravating effect of Plasmodium parasitaemia on deranged levels of trace elements in Nigerians with sickle cell disease.
  O.G. Arinola , S.O. Nwozo , J.A. Ajiboye and A.H. Oniye
  The consumption and export cassava or cassava product is on the increase, thus more Nigerians are involved in the planting and processing of cassava stems and tubers respectively. Tropical ataxic neuropathy (TAN) and diabetes Mellitus (DM) are among the cassava-cyanide induced conditions in rural Nigerians that engaged in processing and consumption of cassava products. TAN and DM are associated with certain trace elements, therefore this study determines the levels of trace elements (Mg, Fe, Zn, Mn, Cu, Cr, Cd, Pb) and total antioxidant (TAS) in 36 Nigerian cassava processors and 24 controls using spectrophotometric methods. The mean levels of Mg, Pb, Cd, Cr and Cu were not significantly raised in cassava processors compared with the controls. Also, the mean levels of essential trace elements such as Se, Zn, Fe, Mn and TAS were not significantly reduced in cassava processors compared with the controls. Fairly raised levels of toxic metals (Pb and Cd) and reduced levels of nutritionally essential trace elements (Se, Fe and Zn) call for future concern about the health status of long-time cassava processors.
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