|
|
| |
| Articles
by
O.F.C. Nwodo |
Total Records (
2 ) for
O.F.C. Nwodo |
|
 |
| |
|
| |
O.F.C. Nwodo
,
P.E. Joshua
,
M.C. Ugwuoke
and
R.I. Uroko
|
| |
The study investigated the effect of ethanol extract of Zapoteca portoricensis roots on malaria-infected mice. The effect of ethanol extract on malaria infected mice was studied by assaying percentage parasitaemia, some liver marker enzymes and kidney function markers. The acute toxicity study showed that the ethanol extract had LD50 above 2900 mg kg–1 b.wt. Malaria infected mice treated with the ethanol extract had significant (p<0.05) decrease in the mean percentage parasitaemia when compared with group 2 mice (malaria untreated). The AST activity showed significant (p<0.05) increase in all the test groups when compared to normal control on day 14 but significantly (p<0.05) reduced in all the treated groups when compared to group 2 mice on day 28. The ALT and ALP activities decreased significantly (p<0.05) in all the test groups when compared to group 2 mice. The urea concentration significantly (p<0.05) decreased in the normal control, group 4 and 5 when compared with group 2 mice. Creatinine concentration decreased significantly (p<0.05) in the normal control, group 3 and group 4 when compared to group 2 mice on day 14, however, on day 28, no significant (p>0.05) differences were observed in the creatinine concentrations in all the groups when compared to normal control. The results suggest that the ethanol extract of Zapoteca portoricensis roots is relative safe has no negative effects on liver and kidney with huge potentials in the management of malaria. |
|
|
| |
|
| |
E. Joshua Parker
,
Nweje-Anyalowu Paul Chukwuemeka
,
O.F.C. Nwodo
and
Uroko Robert Ikechukwu
|
| |
The study investigated the effect of methanol extract of R. communis seeds on blood glucose levels, antioxidant enzymes and haematological parameters of alloxan induced male Wistar albino rats. The methanol extract had LD50 value above 5000 mg kg–1 b.wt. After alloxan induction of diabetes, a significant (p<0.05) decrease in blood glucose levels were observed in all the test groups treated with the extract, when compared with positive control (group 2). The extract treated groups showed significant (p<0.05) increase in PCV, Hb, RBC and significant decrease (p<0.05) in WBC counts, when compared with positive control, however, no significant (p<0.05) difference was observed in total serum protein. With exception of group 4, malondiadehyde concentration decreased significantly (p<0.05) in test groups relative to positive control. A concentration dependent increase in glutathione activity in extract treated groups close to metformin treated group was observed when compared with normal and positive controls respectively. At higher concentrations of the extract, superoxide dismutase activity increased significantly (p<0.05) when compared with positive control. At lower concentrations of the extract, catalase activity increased significantly (p<0.05) close to metformin treated group but decreased significantly (p<0.05) with increasing concentrations of the extract close to positive control. The results of the study showed that the methanol extract of RC possess antihyperglycaemic properties and ability to modulate activities of antioxidant enzymes. It also suggests that the extract has positive effect on the haematological parameters. |
|
|
|
|
| |
|
