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Articles by O.B. Familoni
Total Records ( 5 ) for O.B. Familoni
  M.O. Sofidiya , O.A. Odukoya , A.J. Afolayan and O.B. Familoni
  Ethnobotanical survey conducted presents findings on medicinal plants commercialized and used for the treatment of inflammatory diseases in the major herb markets in Lagos metropolis. Data were collected through direct interview with traditional herb sellers using unstructured questionnaires. Study revealed a total of 41 plants species belonging to 23 families. Botanical and local names, plant part used, methods of preparation and administration are described. The part of the plants most frequently used was the leaves 55%, stem bark (14%), root (11%), whole plant (9%), sap (5%), aerial parts, flowers and fruits (2%) each. There was a high degree of informant consensus for the family Sapindaceae while oral and topical routes of administration are commonly employed.
  O.O. Ajani , O.B. Familoni , D.V. Aderohunmu , K.O. Ogunniran , J.A. Adekoya and I.O. Olanrewaju
  Reaction of p-toluenesulfonyl chloride with amino acids gave sulfonamides p-T1a-k which upon amidation afforded p-T2a-k. Similarly, treatment involving α-toluenesulfonyl chloride and amino acids afforded the sulfonamides α-T1a-k. These two classes of sulfonamides were synthetically modified at their COOH end position to achieve N,N-diethylamido substituted p-toluenesulfonamides p-T2a-k and α-toluenesulfonamides α-T2a-k, respectively. The chemical structures of the compounds were validated with IR, Mass spectra, NMR as well as elemental analytical data. Both classes of compounds were screened against Escherichia coli and Staphylococcus aureus and their activity were compared. It was remarkable to note that the α-toluene sulfonamides α-T2a-k were more active than their p-toluenesulfonamide counterparts p-T2a-k. Compound 1-(benzylsulfonyl)-N,N-diethylpyrrolidine-2-carboxamide α-T2a was the most potent antibacterial compound on S. aureus with MIC value of 3.12 μg mL-1 while N,N-Diethyl-3-phenyl-2-(phenylmethylsulfonamide) propanamide α-T2j emerged as the best antibacterial motif against E. coli with MIC value of 12.5 μg mL-1. Hence, these compounds especially the α-toluenesulfonamide core structural templates are good candidates for further study for future drug discovery.
  E.A.S. Osibote , M. Ogunlesi , W. Okiei , T. Asekun and O.B. Familoni
  One of the causes of male infertility factor is venereal diseases. Cissus populnea and Sesamum radiatum are two tropical medicinal plants used to correct male infertility factor. The aim of this study was to extract the essential oil from the stem powder of C. populnea and the leaves of S. radiatum and screen them for antimicrobial activity. The essential oil from the two plants were obtained by hydro-distillation and were both found to inhibit the growth of Gram-negative and Gram-positive bacteria including Citrobacter sp., Escherichia coli, Escherichia coli ATCC 25922, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus albus and Staphylococcus aureus. The essential oil from C. populnea was in addition found to be active against Enterococcus faecalis, Staphylococcus aureus ATCC 25923 while the essential oil from S. radiatum was found to be active against Serratia marcescens. The essential oil samples from the two plants were both inactive against Candida albicans. The results confirm the antimicrobial properties of the essential oil from the two plants and hence, these plants may correct male infertility factor arising from bacterial infection.
  O.T. Asekun , S.O. Okoh , O.B. Familoni and A.J. Afolayan
  Natural antioxidants have been proven safe and potent for the treatment and prevention of several human diseases. This study aimed to investigate the chemical profiles and antioxidant activities of essential oils extracted from the leaf and stem of Parkial biglobosa (Jacq) Benth. The leaf and stem of the plant were subjected to hydro-distillation (modified Clevenger apparatus) to obtain essential oils analyzed by GC/MS method. The antioxidant activities of the oils were determined by evaluating their scavenging activities against DPPH, ABTS and nitric oxide using different concentrations (0.5, 0.2, 0.05 and 0.025 mg mL-1). Positive controls were vitamin C and rutin. The essential oils extracted from the leaf and stem contained 34 and 15 constituents accounting for 84.9 and 95.9% of the total oil, respectively. Of the 34 eluted, 33 compounds were identified in the leaf essential oil. The major components were limonene (16.0%), hexadecanoic acid (12.5%) and farnesene (10.2%). Thirteen compounds were identified in the stem oil, the major compounds were caryophyllene oxide (16.6%), β-caryophyllene alcohol (14.9%), terpinene-4-ol (12.1%) and β-caryophyllene (8.1%). The three antioxidant assays were concentration dependent with varying antioxidant potentials. The antioxidant activity of the stem and stem oils were similar to that of the standard drugs used. The present findings suggest that the essential oils obtained from the leaf and stem of P. biglobosa posses strong antioxidant potential and can be used to produce natural antioxidants as well as natural food preservatives.
  M.O. Sofidiya , F.O. Jimoh , A.A. Aliero , A.J. Afolayan , O.A. Odukoya and O.B. Familoni
  Lecaniodiscus cupanioides Planks. ExBth (Sapindaceae) is widely used in Nigerian folk medicine for the treatment of inflammatory conditions, hepatomegaly and bacterial infections. This study investigated the antioxidant and antibacterial activity of the methanolic extract of the leaves to justify its use in traditional medicine. Extract exhibited strong DPPH and ABTS radical scavenging activity greater than BHT and comparable to ascorbic acid. 0.1 mg mL-1 extract inhibited DPPH and ABTS radicals up to 99.4 and 98.5%, respectively. Multiple antioxidant activity of extract was evident with moderate reducing power. TAE (37.678±1.66 mg g1 dry extract) was higher than that reported in many other plant extracts. Flavonoid and proanthocyanidin contents were 4.142±0.06 and 2.548±0.32 mg g-1, respectively. Strong correlation recorded; ABTS/TAE (R2 = 0.89), DPPH/TAE (R2 = 0.90). Antimicrobial activity was highest on gram +ve organisms B. cereus, S. aureus, M. kristine and S. pyrogens (MIC value < 1.0 mg mL-1). Gram-ve S. pooni and P. aeruginosa (MIC value = 2.0 mg mL-1). Results attributed the antioxidant potential of L. cupanioides leaf extract to its strong proton donating ability and justified its use for the treatment of bacterial infections in ethnomedicine.
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