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Articles by O.B. Adu
Total Records ( 4 ) for O.B. Adu
  H.A. Bankole , O.A. Magbagbeola , O.B. Adu , A.A. Fatai and B.A. James
  The aim of this study was to investigate the probable mode of action of ethanolic extract of Phyllanthus amarus traditionally used to correct erectile dysfunction by monitoring the effect on the concentration of penile cyclic guanosine mono-phosphate (cGMP) and the concentration of plasma Nitric Oxide (NO) in male guinea pigs that were administered different doses (100, 200 and 400 mg kg-1 body weight) of the plant extract using direct immunoassay kits. Physiological saline and sildenafil were given to animals that served as the controls. Phytochemical screening of the plant determined included alkaloids, flavonoids, terpenoids, saponins, tannins, steroids and cardiac glycosides. There was no statistical significant difference in the weight of the animals before and after the administration of the plant extract. The penile weight per body weight ratio showed a significant difference between groups (p<0.05). There was a dose dependent increase in the level of cGMP in the different groups administered different doses of the extract, with the 400 mg kg-1 group showing significant difference compared to lower-dose and saline groups (p<0.05). Plasma nitric oxide concentration was not significantly different among the control and experimental groups. Conclusively, ethanol extract of the plant had a dose dependent increase on the level of cGMP which might account for the claim of the plant been use as a sexual stimulant and the increase level of the cGMP probably had a feedback effect on nitric oxide synthase which resulted to reduced concentration of NO in the plasma.
  M. I. Kazeem , B.F. Oyedapo , O.G. Raimi and O.B. Adu
  The sharp increase in the incidence and prevalence of diabetes mellitus has led to antidiabetic therapeutic investigations. Therefore, the aim of this study was to evaluate different extracts of Ficus exasperata leaves for their inhibitory potential against α-amylase and α-glucosidase activities. Phytochemical screening of the various extracts of Ficus exasperata was performed and their inhibitory potential on the activities of α-amylase and α-glucosidase was determined in vitro. The results revealed that aqueous extract of Ficus exasperata has the lowest IC50 against α-amylase (3.70 mg mL-1) and α-glucosidase (1.70 mg mL-1) which makes it most potent inhibitor compared to the other extracts. Kinetic studies performed on the aqueous extract of Ficus exasperata in order to determine its modes of inhibition of the enzymes showed that it is a non-competitive and competitive inhibitor of α-amylase and α-glucosidase respectively. It is proposed that the inhibitory potential of aqueous extract of the plant might be due to the synergistic effect of its phytochemical constituents. Therefore it can be concluded that part of the mechanisms by which Ficus exasperata displayed its antidiabetic potential is through the inhibition of α-amylase and α-glucosidase.
  B.O. Elemo , O.B. Adu , O.O. Ogunrinola , T.O. Efuwape , K.O. Olaleye and A.A. Kareem
  Potential application of T. danielli waste as a raw material in livestock feed formulation had been suggested in earlier reports. In this study, the nutritional quality of protein in Thaumatococcus danielli seed and pericarp was evaluated using 16 male waster rats (20-25 g). The animals were randomly assigned to 4 groups and were maintained on four isocaloric diets, namely: casein, seed, pericarp and nitrogen-free diets, for 10 days. Daily weight gain and feed intake over the last 7 days were measured. Feacal, carcass, and feed nitrogen contents were also determined at the end of the feeding trial. Protein Efficiency Ratio (PER), Net Protein Retention (NPR), Biological Value (BV), Net Protein Utilization (NPU) and True Digestibility (TD), were thereafter calculated. Mean weight gain was significantly lower (p>0.05) in the rats fed the T. danielli pericarp feed (-2.60±0.80 g) than those placed on the seed (5.46±0.71 g). PER (-2.11±0.09); TD (59.37±1.72%); BV (16.96±1.61%); NPU (76.13±1.01%); and NPR (2.53±0.22) values were also significantly lower (p<0.01) in the pericarp than in the seed (2.19±0.23, 82.02±1.25%, 58.04±11.54%, 90.86±1.25% and 4.54±0.43 respectively). The quality of T. danielli seed protein compared favourably with that of the casein based diet. There was no significant difference (p>0.05) in the BV, PER, and NPU values between the casein based and the T. danielli based diets. The NPR value of the seed was significantly higher (p<0.05) compared to the casein diet.
  O.O. Ogunrinola , O.O. Fajana , S.N. Olaitan , O.B. Adu and M.O. Akinola
  Diabetes mellitus is the most common endocrine disorder of man, whose devastating effect is increasing by the day and severity almost at epidemic level. This study was carried out to investigate the anti-diabetic activity of Ipomoea batatas (sweet potato) leaves extract and its effect on hepatic enzymes, total protein and albumin in alloxan induced diabetic rats. A total of twenty animals was divided into four experimental groups consisting of five animals each. The groups included a positive control, negative control, diabetic-treated Ipomoea batatas and Diabetic-treated tolbutamide for 14 days. All were fed normal diet ad libitum. After the treatment a significant reduction was observed in fasting serum glucose levels in the treated diabetics’ rats. There was a significant (p<0.05) reduction of feed and water intakes by the animals after the treatment with Ipomoea batatas and tolbutamide. Treatment also improved the weight gain compared to untreated diabetic rats. Alkaline phosphatase activity in the diabetes untreated is significantly higher compared to that normal and treated animal and others treated with extract and tolbutamide. A Similar trend was observed in the Aspartate transaminase and Alanine transaminase activity, respectively, the reversed was observed in the albumin and total protein level, respectively. Hence, the result shows that the extract is not toxic and possesses anti-diabetic properties.
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