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Articles by O.A.T. Ebuehi
Total Records ( 4 ) for O.A.T. Ebuehi
  O.A.T. Ebuehi and A.C. Oyewole
  The blood chemistry, hematological and oxidative stress parameters of anaemic rats fed iron-fortified Nigerian Ofada rice with Ferrazone® (NaFeEDTA) were investigated. Forty male rats were divided equally into 4 groups. Groups 1 and 2 were induced with anaemia using phenylhydrazine and were fed with and without iron fortified diet respectively, while groups 3 and 4 which served as control were non-anaemic and were fed with and without iron fortified diet respectively, for 30 days. The blood chemistry, electrolyte level, hematology, anti-oxidant enzyme activities and tissue histology were determined. Packed cell volume , hemoglobin level and red blood cell count were significantly (p<0.01) increased in rats fed with/without iron fortified diet as compared to the control. The activities of aspartate amino transferase, alanine amino transferase, direct bilirubin, creatinine and triacylglycerol levels were significantly increased in anaemic rats fed with iron fortified diet as compared with the control. There was a significant decrease in superoxide dismutase (SOD) activity and malonyldialdehyde (MDA) level of anaemic rats fed with fortified diet as compared with the control group, while there was a significant increase in SOD and catalase activities and a decrease in MDA level of anaemic rats fed with unfortified diet. There was a significant decrease in sodium and potassium levels and increased in the brain iron levels of anaemic rats fed with iron fortified diet as compared with the control. Data of the study show that iron fortification using Ferrazone® affected the hematology, lipid peroxidation, electrolytes and blood chemistry of rats.
  O.A.T. Ebuehi and K.C. Mbara
  The blood chemistry, hematological and oxidative stress parameters of anaemic rats fed iron-fortified gari was investigated. Yellow gari, popular Nigerian fermented cassava gruel, was fortified with Ferrazone® (NaFeEDTA). Twenty albino rats were divided into Groups 1, 2, 3 and 4. Groups 1 and 2 were made anaemic by phenylhydrazine administration and fed with or without fortified gari, respectively for 30 days, while groups 3 and 4 were non-anaemic and fed with or without fortified gari respectively for 30 days. Groups 2 and 4 were used as the controls for the anaemic and non-anaemic rats, respectively. The blood chemistry, hematology, antioxidant enzyme activities and brain mineral composition were analysed. Histological examination of the brain, liver and heart of rats were assayed. There was no significant change in plasma levels of creatinine, triglyceride, glucose and brain levels of reduced glutathione and malonyldialdehyde of rats fed with or without iron-fortified gari. The hemoglobin and haematocrit levels were significantly increased after consumption of iron-fortified gari. The aspartate aminotransferase, alkaline phosphatase activities and bilirubin level of rats fed with iron fortified gari were significantly decreased, while alanine aminotransferase activity increased significantly. There was a significant decrease in the superoxide dismutase and catalase activities between the iron-fortified fed rats and the controls. There were no significant differences in the cellular architecture of the brain liver and heart of anaemic rats fed iron fortified gari. It could be suggested that iron fortification of gari using Ferrazone® NaFeEDTA contributed to protect and preserve the integrity of the brain, liver and heart, blood chemistry and antioxidant enzymes.
  M. Ozaslan , I.D. Karagoz , R.A. Lawal , I.H. Kilic , A. Cakir , O.S. Odesanmi , I. Guler and O.A.T. Ebuehi
  Background: Tetrapleura tetraptera fruit is widely used in Southern Nigeria for a range of pharmacological actions. Methodology/Principal Findings: In this study, the cytotoxic and antiproliferative effects of the ethanolic extract of fruit were studied in vitro and in vivo by using ehrlich ascites carcinoma cells and tumor modelling, respectively. Cytotoxic activity was determined by incubating the ehrlich ascites carcinoma cells with 0.1, 1, 10 and 100 μg mL–1 of the extract. In vivo study, 20, 40 and 80 mg kg–1 b.wt., doses of the extract was inoculated by intraperitoneal administration to mice following to carcinoma cells inoculation by same way. The extract was cytotoxic to carcinoma cells as assessed by both in vitro and in vivo experiments. Conclusion/Significance: The IC50 of the extract was found to be 250 μg mL–1. Results showed that the Tetrapleura tetraptera increased the life span of mice via reducing the number of the viable EAC cells, decreasing in ascites fluid volume and tumor burden. The DNA fragmentation assay also showed that it has a possible pro-apoptotic effect.
  O.A.T. Ebuehi , Q.C. Opara and A.I. Akinwande
  The effects of oral administration of aspirin and paracetamol on plasma and brain protein, tryptophan concentrations and monoamine oxidase activity were investigated. Fifty-four virgin albino Sprague-Dawley rats were used for the study and divided into three groups. The first group of rats was fed rat chow with water ad libitum and oral administration of 0.05% (w/v) aspirin and the second group of rats was fed rat chow with water, ad libitum and oral administration of 0.05% (w/v) paracetamol for 35 days. The third group of rats serves as the control and fed with rat chow and water ad libitum for 35 days. The rats were sacrificed by decapitation after starving them overnight and their blood and brain were collected quickly. Plasma and brain protein and tryptophan concentrations and brain monoamine oxidase activity were assayed. Results showed that oral administration of aspirin and paracetamol do not significantly (p< 0.01) affect body weight, feed and water intake of rats. But these drugs significantly elevated plasma protein, tryptophan and decreased brain protein and tryptophan concentrations. Oral administration of aspirin significantly inhibited brain monoamine oxidase activity, but was not affected by paracetamol. Data of the present study indicate that aspirin, but not paracetamol could alter the metabolism and neurotransmission mediated by certain biogenic amines catalyzed by monoamine oxidase in the brain.
 
 
 
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