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Articles by O.A. Otubanjo
Total Records ( 4 ) for O.A. Otubanjo
  O.A. Otubanjo , A.A. Mosuro and T. F. Ladipo
  The in vivo effects of orally administered ivermectin (Mectizan®) on sperm head morphology of albino mice were evaluated. Four different dose levels of 0.25, 0.5, 1.0 and 1.5 x the human therapeutic dose of 150 g kg-1 body weight, were administered to the animals. The animals were exposed to a single oral treatment. The sperm of the mice from the cauda epididymes were examined 5 and 7 weeks after treatment. Ivermectin (Mectizan®) induced sperm head abnormalities; however, the induction was not significantly elevated above the negative control value. Furthermore, the induction of the sperm head abnormalities was not strictly dose-dependent and there was also no correlation between dose level of administered drug and incidence of abnormal sperms. This indicates that the drug might not be mutagenic.
  B. Akinsanya , A.A. Hassan and O.A. Otubanjo
  A comparative study of the gut helminthes of Gymnarchus niloticus and Heterotis niloticus were undertaken. A total of 38 fishes comprising of 20 Gymnarchus niloticus and 18 Heterotis niloticus were examined for helminth parasites. The overall prevalence of gastrointestinal helminth infections was 34.2%, which implied that 13 of the specimens examined were infected with parasites. A total of 18 parasites were recovered from the fish specimens. The male specimens of Heterotis niloticus had 38.9% prevalence of infections while the male specimens of Gymnarchus niloticus had 0% prevalence of infections. The female specimens of the two fishes had 50% prevalence of infections. Gymnarchus niloticus harboured two nematodes; Raphidascaroides species in the stomach and the Philometrids, Nilonema gymnarchi, in the intestine. Heterotis niloticus were infected with a trematode Brevimulticaecum heterotis in the liver and Tenuisentis niloticus and Sandonella sandoni in the intestine. The worm burden and intensity were low and independent of sex and age of fish with no seasonal variation in parasite intensity observed. The low prevalence of infection is possibly due to the randomness of specimens` selection.
  O.A. Otubanjo and A.A. Mosuro
  The effects of sulphamethoxypyridazine: Pyrimethamine (Metakelfin®) a combination antimalarial drug on mouse sperm head morphology were evaluated in University of Ibadan Veterinary F1 mice. Five different dose levels of 3.85:0.19; 7.7:0.38; 15.4:0.76; 23.1:1.13 and 30.8:1.54 mg kg-1 body weight of sulphamethoxypridazine:pyrimetamine, respectively were administered to the animals by a schedule of 5 consecutive daily intraperitoneal (i.p.) injections. The sperm of the mice from the cauda epididymis were examined 5 weeks after treatment. Metakelfin® induced sperm head abnormalities; however, of the 5 doses sampled; only the 7.7:0.38 mg kg-1 dose, corresponding to 0.5x the human therapeutic dose (HTD0, gave a statistically significant (p>0.05) increase over the negative control value of 2.53% abnormality. All the other dose level treatments did not yield statistically significant increase over the negative control value. The 15.4:0.77 mg kg-1 dose showed 3.5% abnormality and fewer abnormalities than the preceding lower dose. The drug is probably not mutagenic as induction of sperm head abnormality was not dose ependent.
  A.F. Ayorinde , B.O. Oboh , O.A. Otubanjo , A.C. Alimba and P.C. Odeigah
  Although, toxicity of some mosquito repellents has been reported, effects of different doses on some parameters and different sexes is not clear. This study was aimed at determining the toxicity of a commonly used mosquito repellent in Lagos State, Nigeria. The effects studied in rats were based on some hematological parameters, body weight/organ indices (Relative organ weights) and histopathological analysis. The rats were divided into two groups of 6 males and 6 females each and a control of 2 males and 2 females. The two groups were exposed to one and two mosquito repellents per day for one, two and four weeks, respectively. Hematological analysis showed increase in White Blood Cell (WBC) counts in the females and males exposed for 2 weeks and above (p<0.05). Increase was also recorded in the percentage of Mixed Population of White Blood Cells (MXD%) of females and males rats exposed for 2 weeks and above (p<0.05). Platelets (PLT) counts in the female rats (after 2 weeks) also increased when compared with the control (p<0.05). For relative organ weights, significant difference was observed in relative spleen (p<0.05), heart (p>0.05) of both female and male animals and thymus (p<0.05) of the female animals only when compared with control. The histopathological studies showed a severe damage to the lungs whereas no damage was observed in the liver and kidney in both male and female rats. These results show that exposure to Black coil could be detrimental to health.
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