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Articles by O.A. Osonuga
Total Records ( 3 ) for O.A. Osonuga
  I.O. Osonuga , O.A. Osonuga , A. Osonuga , A.A. Onadeko and A.A. Osonuga
  The aim of the research was to evaluate the likely effects of Halofantrine on liver enzymes in healthy and uninfected Wistar rats of both sexes. Thirty albino rats (randomly assigned into 3 groups of 10 rats each) with body weight of 150 - 230 g were used for the 2-phase study. In phase 1, the drug was administered orally at Therapeutic (T) dose of 2.15 mg per 100 g body weight to 10 rats (5 males and 5 females) daily at 6 h interval for 18 h. Phase II was a recovery study involving 10 rats (5 males and 5 females) exposed to dose regimen as in phase 1 and sacrificed after 18 h withdrawal of treatment. The control-group made of 10 rats was given sterile water and rat feed ad-libitum. Halofantrine caused significant increase (p< 0.05) in the liver enzymes (ALK, ALT and AST) of the animals. Discontinuation of the drug use caused significant decrease in the liver enzymes values in the recovery group. The results suggested that halofantrine could induce hepatotoxicity in the treated animals.
  Y. Raji , Olufadekemi T. Kunle-Alabi , S.B. Olaleye , M.A. Gbadegesin , F.O. Awobajo , O.A. Osonuga , A.O Odukanmi , S.A Salami and Adeyombo F. Bolarinwa
  Antimicrobial drugs have been reported to have adverse effects on male fertility. The present study reports the role of α- tocopherol on metronidazole and tetracycline induced reproductive alterations in albino rats. Male albino rats (5/group) were treated with 20 mg kg-1 bw day-1 metronidazole or 60 mg kg-1 day-1 tetracycline with or without 15 mg kg-1 bw α-tocopherol for 8 weeks. The reversibility of effects after 4 weeks recovery period was determined in separate groups of 5 rats. The control groups received distilled water (vehicle) and 15 mg kg-1 day-1 α- tocopherol for 8 weeks. Metronidazole and tetracycline significantly (p<0.05) reduced the weight of the epididymis, sperm count, motility and serum testosterone levels and increased the activity of endogenous superoxide dismutase (SOD) in the testis. Alpha-tocopherol significantly (p<0.05) decreased the weight of the testis, epididymis, sperm motility and serum testosterone levels. Co-administration of metronidazole or tetracycline with α-tocopherol caused significant restoration in sperm indices and SOD activity while it produced no effect on testosterone secretion. The results suggest that the effects of metronidazole and tetracycline on male reproductive functions, which are partially reversible, could be mediated via a reduction in serum testosterone level and probably also via the free radical generating mechanism.
  O.A. Osonuga , I.O. Osonuga , O.S. Akinsomisoye , Y. Raji and O.G. Ademowo
  Efforts in this study were directed at comparing changes in Packed Cell Volume (PCV) in the cause of treatment of severe malaria patients with artemether and quinine in Ikenne Local Government area of Ogun State, Southwest, Nigeria. Thirty two patients in the study were randomly assigned to receive either artemether or quinine under medical supervision. 16 patients were allocated into two treatment groups. Patients in the quinine group received quinine 10 mg kg-1 in 5% dextrose-saline infusion intravenously at 8 h intervals but changed to oral quinine ( 10 mg kg-1 b.w; 8 h intervals) for 7 days . The patients in the artemether group received 1.6 mg kg-1 artemether twice at day 0 and then 1.6 mg kg-1 daily for the next four days through deep intramuscular route. The patients were then followed up for 14 days. The results this study showed that the PCV of the patients was 25.9% (range of 14-41%) at day 0. The mean PCV of the patients was 26.25% and 25.56% following quinine and artemether treatments, respectively. The mean PCV at day 14 was 34.5 and 38.2%, respectively for quinine and artemether. The results from this study indicate that artemether relative to quinine has a faster and sustained recovery from malaria induced anaemia.
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