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Articles by O.A. Odukoya
Total Records ( 8 ) for O.A. Odukoya
  O.A. Odukoya , S.I. Inya-Agha , F.I. Segun , M.O. Sofidiya and O.O. Ilori
  Antioxidant activity of hot water extracts of 21 Green Leafy Vegetables (GLV): Amaranthus hybridus Linn. (Amaranthaceae), Amaranthus caudatus (Amaranthaceae), Beilschmedia manni (Meisn.) Benth. Et Hook.f. (Lauraceae), Celosia argentea var argentea (L.) O. Kuntze (Amarantheceae) Celosia argentea var cristata Linn. (Amarantheceae), Corchorus olitorius L. (Tiliaceae), Crassocephalum crepidioides (Benth). S.Moore (Asteraceae), Gnetum bucholzianum Welw. (Gnetaceae), Gongronema latifolium Benth. (Asclepiadaceae), Heinsia crinita (Afz.) G. Taylor (Rubiaceae), Hibiscus callyphyllus Cav. (Malvaceae), Lasianthera africana P. Beauv (Icacinaceae), Myrianthus arboreus P. Beauv. (Urticaceae), Pterocarpus mildbraedii Harms (Papilionaceae), Pterocarpus santalinoides DC. (Papilionaceae), Solanum macrocarpon L. (Solanaceae), Solanum melongena Linn. (Solanaceae), Struchium sparganophora (Linn.) O. Ktze (Asteraceae), Talinum triangulare (Jacq.) Wild. Portulacaceae, Telferia occidetalis Hook (Curcurbitaceae) and Vernonia amygdalina Del. (Asteraceae) was investigated. Potential free radical scanvenging activity of these vegetables was confirmed by spraying spots of the extracts with DPPH (yellow color on purple background). Antioxidant activity was assayed in linoleic acid model system. Total polyphenols as Tannic Acid Equivalent (TAE) and ascorbic acid were evaluated spectrophotometrically. The activity of each extract was calculated as %inhibition of lipid peroxidation. The extracts showed marked antioxidant activity in linoleic acid model systems. Antioxidant values (AA) ranged from as low as 3.67% in A. hybridus to as high as 68.41% in C. argentea var cristata. Phenol content (TAE) varied from 21.83 mg/100 g dry weight in T. triangulare to 546.97 mg/100 g dry weight in G. bucholzianum. Ascorbic acid content (ASC) was from 13.41 mg/100 g dry weight in V. amygdalina to 187.11 mg/100 g dry weight in G. latifolium. There was low correlation between AA/TAE (R2 = 0.432), AA/ASC (R2 = 0.28) and TAE/ASC (R2 = 0.35), respectively.
  G.A. Agbelusi , O.A. Odukoya and A.F. Otegbeye
  This study investigated the antibacterial and antifungal properties of Jatropha curcas Linn. (Euphorbiacea) sap and aqueous extracts of nine selected indigenous chewing sticks (Afzelia africana Sm. ex Pers. (Caesalpiniaceae), Balanites wilsoniana Dawe and Sprague (Zygophyllaceae), Dialium guineense Willd. (Fabaceae), Hoslundia opposita Vahl. (Lamiaceae), Masularia acuminata (G.Don) Bullock ex. Hoyle(Rubiacea), Rauwolfia vomitoria Afz. (Apocynaceae), Terminalia glauscens Planch. (Combretaceae) and Vernonia amygdalina Del. (Asteraceae). Bacterial isolates were obtained from mouth washings from a total of 50 patients (32 healthy and 18 sick patients at the Dental Center of the Lagos University Teaching Hospital, Nigeria).16 (89%) samples yielded mainly pathogens while 2 (11%) yielded normal flora from sick patients. Extracts of N. latifolia and sap of J. curcas showed marked antibacterial/antifungal and anti-Methicillin Resistant Staphylococcus aureus (MRSA) activity. Thus could complement traditional hospital oral care protocol for immunocompromised oral infections.
  O.A. Odukoya , M.O. Sofidiya , O.O. Ilori , M.O. Gbededo , J.O. Ajadotuigwe and O.O. Olaleye
  Free radicals are generated in ano-rectal diseases and stress process results in pain, inflammation, swelling, itching and tenderness. The present study investigates the benefit of astringent herbs in hemorrhoid therapy. Astringent herbs used locally in the treatment of hemorrhoids [Achyranthes aspera Linn. (Amarantheceae), Adansonia digitata Linn. (Bombacaceae), Dialium guineense Willd (Leguminosae), Harungana madagascariensis, Kigelia africana (Lam.) Benth. (Bignoniaceae), Newbouldia leavis Seem. (Bignoniaceae) and Spondias mombin Linn. (Anacardiaceae)] were subjected to assay. Astringency was measured as the amount of tannin precipitated by a standard protein Bovine Serum Albumin (BSA) using ferric chloride blue chromophore at an absorbance maximum at 510 nm. The effects of these plant extracts on Scomber japonicum Houttuyn (Scombridae) lipid peroxidation was accessed by thiobarbituric acid reactivity method measured at UV 532 nm and expressed as MDA equivalent/mg of tissue. Total phenol and flavonoid contents were determined as gallic acid and rutin equivalents, respectively. Astringency of extracts was in the order of Spondias leaves>Dialium seeds>Dialium leaves>Newboldia leaves>Kigelia fruit>Spondias fruit>Kigelia bark>Harungana bark>Newboldia bark>Harungana leaves >Adansonia leaves>Achyranthes leaves. Astringency correlated positively with total phenols (r2 = 0.7944), inhibition of lipid peroxidation (r2 = 0.6596 with raw homogenate and 0.9220 with cooked homogenate), low correlation with flavonoid (r2 = 0.059) and no correlation between total phenol and flavonoid content (r2 = -0.0387). It is proposed that these astringent herbs accomplish haemorrhoid therapy by inhibiting lipid peroxidation and plugging up minute leaks and holes in the veins and capillaries thereby promoting vein elasticity and acting as vasoconstrictors in the perianal area.
  M.O. Sofidiya , O.A. Odukoya , A.J. Afolayan and O.B. Familoni
  Ethnobotanical survey conducted presents findings on medicinal plants commercialized and used for the treatment of inflammatory diseases in the major herb markets in Lagos metropolis. Data were collected through direct interview with traditional herb sellers using unstructured questionnaires. Study revealed a total of 41 plants species belonging to 23 families. Botanical and local names, plant part used, methods of preparation and administration are described. The part of the plants most frequently used was the leaves 55%, stem bark (14%), root (11%), whole plant (9%), sap (5%), aerial parts, flowers and fruits (2%) each. There was a high degree of informant consensus for the family Sapindaceae while oral and topical routes of administration are commonly employed.
  O.A. Odukoya , S.I. Inya-Agha , F.I. Segun , G.A. Agbelusi and M.O. Sofidiya
  Astringents contract the tissues and canals of the body. Chewing sticks are used for oral hygiene both as an antibacterial and desensitizing agent. Astringency of cold water extracts of Afzelia africana Sm. ex Pers. (Caesalpiniaceae), Dialium guineense Wild. (Fabaceae), Masularia acuminata (G.Don) Bullock ex. Hoyle, Rauwolfia vomitoria Afz. (Apocynaceae), Terminalia glauscens Planch. (Combretaceae), Vernonia amygdalina Del.(Asteraceae) and Zanthoxylum zanthoxyloides (Lam.) Waterman (Rubiaceae) was measured by precipitating extracts with hemoglobin, centrifugation and loss of absorbance measured spectrophotometrically at 578 nm relative to tannic acid as Tannic Acid Equivalents (TAE). Total Tannin (TT) was determined using the protein tannin precipitation method and Total Phenols (TP) with Prussian blue. Relative Astringency (RA) was astringency of tannin present relative to tannic acid. Activity was in the order of Afzelia>Terminalia>Zanthoxylum>Masularia> Vernonia>Rauwolfia>Dialium. TT ranged from 106.92±0.03 mg/100 g dry plant in Dialium to 632.86±0.42 mg/100 g dry plant in Afzelia. TAE was 27.37±0.07 mg/100 g dry plant in Dialium to 148.11±0.07 mg/100 g dry plant in Afzelia. RA correlated positively with TAE (R2 = 0.8763) and TT (R2 = 0.9493). Desensitization may be due to the astringent activity as these extracts will form a protective layer on the exposed dentine; contract/block the tube like channels that pass through teeth and connect to nerves thereby reduce the ability of the nerves to transmit pain.
  O.A. Odukoya , S.I. Inya-Agha and O.O. Ilori
  In vitro antioxidant activity of aqueous extracts of Phyllantus amarus (Schum and Thonn.) Euphorbiaceae, Sida acuta Burman f. (Malvaceae), Sida cordifolia Linn. (Malvaceae) and Xylopia aethiopica (Dunal) A. Rich (Annonaceae) was assessed by lipid peroxidation (LPO) and reduced glutathione content (GSH). Inhibition of peroxidation and GSH oxidation in all concentrations was dose-dependent. % inhibition at 1 mg mL-1 concentration activity for lipid peroxidation was mixture of all plant extracts with S. cordifolia (86.83 ± 1.23) > mixture with S. acuta (72.92± 0.96) >P. amarus (72.03± 0.39) > S. cordifolia (56.82± 0.54) > S. acuta (42.77± 1.76) > X. eathiopica (39.48± 2.07). Inhibition of GSH oxidation was 97.47± 0.42, 83.56± 0.39, 78.33± 0.09, 61.69± 0.87, 56.48± 0.19 and 49.44± 1.13, respectively in the same order.The extracts inhibited lipid peroxidation and GSH oxidation and thus could slow down aging process and improve immune responses.
  C.A. Muanya and O.A. Odukoya
  ROS are important mediators of sperm function. Production of malondialdehyde (MDA), an end product of LPO, has been reported in spermatozoa. Ethnobotanical survey revealed [Anthocleista djalonensis A. Chev (Loganiaceae), Carpolobia lutea G. Don (Polygalaceae), Cassia sieberiana DC (Leguminosae), Chasmanthera dependens Hochst (Menispermaceae), Cissus populnea Guill and Perr (Vitaceae), Cnestis ferruginea DC (Connaraceae), Dioscorea cayenensis Lam. (Dioscoreaceae), Lecaniodiscus cupanioides Planch (Sapindaceae) and Microdermis keayana J. Leonard (Pandaceae)] as common medicinal plants used locally in South West Nigeria to boost libido, induce erection, increase sperm count and consequently male fertility. Inhibition of lipid peroxidation by these plant extracts as index of male fertility was assessed. MDA was assayed by thiobarbituric acid (TBA) reaction on lipid peroxidation in raw/cooked fish homogenates and measured as the amount of thiobarbituric acid reactive Sample (TBARS) in nmol mg-1 tissue. Extracts significantly inhibited extent of lipid peroxidation. A. djalonensis was most active while D. cayenensis was least active in both raw and cooked fish homogenates. TBARS activity/Concentration (R2 = 0.9533 for raw and R2 = 0.9739 for cooked). Thus these plants may be considered as cheap and readily available sources of treating sexual dysfunction in men.
  M.O. Sofidiya , F.O. Jimoh , A.A. Aliero , A.J. Afolayan , O.A. Odukoya and O.B. Familoni
  Lecaniodiscus cupanioides Planks. ExBth (Sapindaceae) is widely used in Nigerian folk medicine for the treatment of inflammatory conditions, hepatomegaly and bacterial infections. This study investigated the antioxidant and antibacterial activity of the methanolic extract of the leaves to justify its use in traditional medicine. Extract exhibited strong DPPH and ABTS radical scavenging activity greater than BHT and comparable to ascorbic acid. 0.1 mg mL-1 extract inhibited DPPH and ABTS radicals up to 99.4 and 98.5%, respectively. Multiple antioxidant activity of extract was evident with moderate reducing power. TAE (37.678±1.66 mg g1 dry extract) was higher than that reported in many other plant extracts. Flavonoid and proanthocyanidin contents were 4.142±0.06 and 2.548±0.32 mg g-1, respectively. Strong correlation recorded; ABTS/TAE (R2 = 0.89), DPPH/TAE (R2 = 0.90). Antimicrobial activity was highest on gram +ve organisms B. cereus, S. aureus, M. kristine and S. pyrogens (MIC value < 1.0 mg mL-1). Gram-ve S. pooni and P. aeruginosa (MIC value = 2.0 mg mL-1). Results attributed the antioxidant potential of L. cupanioides leaf extract to its strong proton donating ability and justified its use for the treatment of bacterial infections in ethnomedicine.
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