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Articles by O.A. Alabi
Total Records ( 2 ) for O.A. Alabi
  O.A. Alabi , O.A. Akinbami , K.O. Ogunwenmo and E.B. Esan
  Garden croton, an ornamental shrub or tree with diverse beautifully colored leaves, shapes and sizes, is used as informal hedge or screen for landscape, interiorscape and bouquet. This study, investigated the effects of cigarette tobacco extract on plant mutation, root regeneration and proliferation in a plant-plant interactive hydroponic assay using two well known reciprocal mutant cultivars (Guinea broad leaf and Guinea narrow leaf) of garden croton. The results showed that 1x10-(4-8) logarithm dilution of a standard teacup (270 mL) cigarette tobacco-infusion enhanced root regeneration, elongation and proliferation above control level. Higher concentrations of extract inhibited root elongation and proliferation. Undiluted tobacco infusion extract (100%) delayed root initiation until four weeks. Overall, the extract enhanced root elongation and proliferation better in the Guinea broad leaf than the Guinea narrow leaf cultivar. There was no sign of induced mutation in the plant cultivars by the extract.
  O.A. Alabi , C.P. Anokwuru , C.N. Ezekiel , O. Ajibaye , U.J. Nwadike , O. Fasasi and M. Abu
  The discovery and exploration of compounds possessing anti-mutagenic and anti-carcinogenic properties are of great importance. This study investigated the anti-mutagenic and anti-genotoxic effect of ethanolic neem extract on dietary-aflatoxin induced genotoxicity. The assays used were: micronucleus (MN) and sperm morphology assays. Nine groups of mice labeled A-I were exposed to dietary-aflatoxin for three weeks after which they were treated with ethanolic neem extract. One week of 0.5 mL intraperitoneal injection of 25, 50 and 100 mg kg-1 b.wt. neem extract were administered in one, two and three doses daily for groups A-C, D-F and G-I, respectively. Three weeks aflatoxin feed mice and mice with no aflatoxin/neem extract exposure were used as controls 1 and 2, respectively. The three weeks dietary-aflatoxin induced a statistically significant (p<0.05) MN and sperm morphology compared to control 2. The three concentrations utilized reduced the genotoxic effects of dietary-aflatoxin on MN and abnormal sperm morphology assay in a concentration-dependent manner. Higher concentrations of 50 and 100 mg kg-1 b.wt. completely reversed the induced genotoxicity. Neem extract is identified with possible anti-mutagenic and anti-genotoxic potential in this study and should be further studied as a natural source of antimutagenic agent for humans.
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