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Articles by O.A. Abu-Zinadah
Total Records ( 2 ) for O.A. Abu-Zinadah
  A.Y. Obaid , O.A. Abu-Zinadah and H.K. Hussein
  This research was carried out to evaluate the potential and beneficial effect of green tea (Camellia sinensis) and its fractions in direct fire burns in comparison with antibiotic manufactured for this purpose using basic morphological and histological methods. Twenty-five animals were divided into five groups (5 animals each). These groups were control untreated group; crude extraction treated group, polyphenol fraction group, terpenes extract group and antibiotic ointment treated group. All types of treatments reduce the wounds to minimum volume at the beginning of the fifth week. Most wounds were recovered completely, giving normal epidermis, dermis and hair growing, whoever some burns showed no hair growth and gave abnormal appearance of newly formed skin. Furthermore, histological findings revealed normal cutaneous architecture of the extract treated wounds more than that appeared in the untreated wounds. The healing capability of Camellia sinensis was evident when compared to the impaired healing process of the wounds administered to the Baneocin antibiotic ointment treated rabbits that illustrated a delay in coagulation and inflammation phase of healing after five weeks of wounding. However, the healing effect of crude extract was more effective than that observed with the Baneocin treated or essential oil derivatives (terpenes and polyphenoles), respectively. The contract ability and closure times of wounds were very high by application of crude extract and antibiotic than those through application of terpenes and polyphenoles. Terpenes gave another way of treatment, it was good antimicrobial material and so did polyphenoles. They prevent microbial growing above the wounds after the first hours of application.
  H.K. Hussein and O.A. Abu-Zinadah
  This study aimed to determine the protective effect of curcumin on streptozotocin (STZ)-induced oxidative stress in various tissues of albino Wister rats. Adult male rats (8 weeks), weighing 195 to 225 g was made diabetic by injecting STZ (65 mg kg-1 body weight) intraperitoneally. During the whole experimental period, animals were fed with a balanced commercial chow and water ad libitum. Diabetic rats given either water or ethanolic curcumin extracts (80 mg kg-1 body weight) in aqueous suspension daily for a period of seven weeks. The levels of oxidative stress parameters and activity of antioxidant enzymes were determined in various tissues. STZ-induced hyperglycemia resulted in increased glucose level, glycosylated haemoglobin in red blood cells and other tissues and altered antioxidant enzyme activities such as AST and ALT. These elevated blood parameters and enzymatic activities induced by hyperglycemia were significantly restored to near normal by oral administration of curcumin once daily for 7 weeks, as compared to untreated rats. There was a significant elevation in the level of liver and kidney malondialdhyde (MDA), while the activities of antioxidant enzymes superoxide dismutase and catalase (SOD and CAT) were significantly decreased in STZ rats which also restored to normal after curcumin treatment. The results obtained indicated that ethanolic extract has more potent protective action than water extract against all hyperglycemic parameters. Biochemical observations were supplemented by histopathological examination of liver and kidney sections. Interestingly, feeding curcumin to the diabetic rats controlled oxidative stress by inhibiting the increase in TBARS and protein carbonyls and reversing altered antioxidant enzyme activities without altering the hyperglycemic state in most of the tissues. So, curcumin appear to be beneficial in preventing diabetes-induced oxidative stress in rats despite unaltered hyperglycemic status.
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