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Articles by O.A. Adeyeba
Total Records ( 2 ) for O.A. Adeyeba
  O.A. Adeyeba , Y.O. Adesiji and P.O. Omosigho
  Diabetic patients comprise a large proportion of our outpatient population and deserve special attention. To determine the prevalence, the clinical characteristics, risk factors, causative organisms and antimicrobial susceptibility of Urinary Tract Infection (UTI) in diabetic patients. Mid-stream urine samples were obtained from a total of 320 patients attending medical outpatient clinic, University College Hospital, Ibadan and apparently healthy volunteers from February to July 2006. Medical records were also reviewed and the patients were divided into two groups according to the presence or absence of diabetes, Patients that were confirmed to be diabetic were included in the study. Out of 320 midstream urine samples examined, 174(54.3%) were diabetic, out of which 37(21%) had significant bacteruria, these include 23(61.9%) females and 14(38.1%) males while in 146 control healthy volunteers only 7(5%) had significant bacteruria, which accounted for 84(58%) of male and 62(42%) of female within the age range of 20-65. Escherichia coli was the predominant bacterial isolate as a causative agent of urinary tract infection in both diabetics and healthy volunteers The antibiotic sensitivity pattern showed that most islolates were sensitive to ofloxaxin, Gentamycin, Nitrofurantoin, Nalixidic acid, Cotrimaxole and Rocephine while they are resistant to tetracyclines, ampicillins, cefuroxime and ceftazidine. The complications of diabetes are of great importance both financially and in terms of mortality and morbidity, because of frequency and severity of UTI in these groups of patients it is recommended that periodic screening of diabetics patients be undertaken to permit early detection and treatment of assymptomatic bacteruria.
  S.S. Taiwo , B.A. Oyekanmi , Y.O. Adesiji , O.O. Opaleye and O.A. Adeyeba
  The aim of this study is to investigate the antibacterial effects of two plant extracts, Citrus aurantifolia linn (lime) and Tithonia diversifolia poaceae (sunflower) commonly used as traditional medicines in Nigeria. The antibacterial activities of aqueous extracts of these two plants were evaluated using disk diffusion susceptibility testing on 53 fresh human bacterial pathogens isolated in Ladoke Akintola University Teaching Hospital, Osogbo, Nigeria. These isolates included 27 Staphylococcus sp., 15 Escherichia coli, 3 Klebsiella sp., 4 Proteus sp. and 4 Pseudomonas sp. The Mean Zone Diameter (MZD) of inhibitions to 5 無 of Citrus aurantifolia linn extracts are 10, 12, 11, 17 and 16 mm for Staphylococcus sp., E. coli, Klebsiella sp., Proteus sp. and Pseudomonas sp., respectively. The MZD of inhibitions to 5 無 of Tithonia diversifolia poaceae extract are 1, 1, 0, 8 and 0 mm and for 5 痢 ciprofloxacin (control) disk are 29, 19, 20, 25 and 15 mm for these respective organisms. Forty four percent (12 of 27) of the Gram positive and 69% (18 of 26) of the Gram negative pathogens showed Zone Diameter (ZD) of inhibition = 10 mm to 5 無 extract of Citrus aurantifolia linn. Four percent (1 of 27) of the Gram positive and 8% (2 of 26) of the Gram negative pathogens showed ZD of inhibition = 10 mm to 5 無 of Tithonia diversifolia poaceae. In comparison, 93% of the Gram positive (25 of 27) and 65% (17 of 26) of Gram negative pathogens showed zone diameter of inhibition = 10 mm to 5 痢 ciprofloxacin (control disk). When compared to ciprofloxacin, 5 無 extract of Citrus aurantifolia linn possess approximately 33% antistaphylococcal activities of 5 痢 ciprofloxacin and approximately the same activity on the Gram negative bacterial isolates tested (p = 0.2767). However, 5 無 extract of Tithonia diversifolia poaceae does not possess any appreciable antibacterial effect on any of the isolates when compared to 5痢 ciprofloxacin disc (p = 0.0045) or when compared to 5 無 extract of Citrus aurantifolia linn (p = 0.0149). Citrus aurantifolia linn showed promising broad spectrum antibacterial effects on human pathogens.
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