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Articles by O. Osilesi
Total Records ( 2 ) for O. Osilesi
  B.A Salau , A.O. Ketiku , O.L. Adebayo , W.E. Olooto , E.O. Ajani and O. Osilesi
  The involvement of sucrose and its amount in the causation of cardiovascular disease is still controversial and inconclusive. The two latest reports of WHO/FAO and Institute of Medicine of Food and Nutritional Board (IOM of FNB) on optimal level of sucrose consumption are at least contradictory; therefore the need to clarify the effect of different concentrations of sucrose consumption on cardiovascular disease risk factor is expedient. Effect of sucrose consumption was assessed on twenty four male albino rats, four to six weeks old, 48-65 g, divided into five groups: G1 (control), G2 (10% energy supply from sucrose), G3 (20% energy supply from sucrose), G4 (30% energy supply from sucrose). The following parameters were determined: red blood cell count, white blood cell count, packed cell volume, blood and plasma viscosities; fibrinogen level and erythrocyte sedimentation rate. Analyses revealed that inclusion of sucrose at concentration of 20% energy supply significantly increased (p<0.05) blood viscosity by 97.59%, plasma viscosity 16.48%, erythrocyte sedimentation rate 40.00%, plasma fibrinogen13.63% and white blood cell count 6.59%, while no significant effect (p>0.05) was observed on red blood cell count and packed cell volume. The study revealed that consumption of sucrose at twenty percent energy supply increased some selected haematological and haemorrheological parameters associated with cardiovascular disease.
  B.A. Salau , M.M. Adeyanju , K.T. Odufuwa and O. Osilesi
  Fruits and vegetables have been shown to contain vital components that moderate disease conditions. However, there is dearth of information of these effects in Africans diabetic subjects. Thus, we investigated the relative effect of fruits and vegetables on some selected heamorological factors associated with cardiovascular disease in diabetic subjects. Thirty diabetic subjects were selected at the cardiovascular clinic of Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria. The subjects with mean Fasting Blood Glucose (FBG) level of 7.8±0.95 mmold L-1 were placed on 300 g of fruits and vegetables per day, while they continued their normal medication and food intake. A significant difference (p<0.05) was noticed between baseline and eight week values in all the parameters, Fibrinogen 262.75±2.64 to 250.57±3.98 mg dL-1, Blood viscosity, 5.96±0.21 to 4.82±0.23 m Pas; erythrocyte sedimentation rate 49.40±2.34 to 32.8±1.26 min h-1 and haematocrit 38.8±1.25 to 44.75±1.05%. At the eight week the fruits and vegetables were withdrawn for two weeks and the above parameters were reassessed (at the 10th week) which were compared with eight week values. Significant difference p<0.05 was noticed in E.S.R. 32.8±1.26 to 38.8±1.23. However no significant difference (p>0.05) was observed in haematocrit, 44.75±1.44 to 42.70±1.24, Fibrinogen, 254.5±3.98 to 250.57±3.16 mg dL-1. The results showed that regular intake of fruits and vegetables by diabetic subjects may reduce cardiovascular risk factors.
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