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Articles by O. Omidiji
Total Records ( 2 ) for O. Omidiji
  A.M. Oloyede , J. Okpuzor , O. Omidiji and H.O.C. Mbagwu
  An herbal cocktail comprising of seeds, stem and leaves of seven African plants extensively used in South-Western Nigeria for the management and treatment of inflammation and tumor of the breast was investigated for analgesic and anti-inflammation activities. The analgesic properties of the ethanol extract was investigated using three in vivo mice test models (mice constriction, hot-plate and formalin-induced pain test) while anti-inflammatory activities of the same were evaluated using the Carageenan and egg albumin-induced oedema test systems in vivo. Present findings indicated that the cocktail at a concentration of 400-1600 mg kg- produced significant inhibition (p<0.05) response in both phases of the formalin pain model. The acetic acid-induced abdominal constriction also showed a dose dependent pain inhibition pattern directly related to the amount of extract administered. Instructively, the extract exhibited higher analgesic activity than acetylsalicylic acid but lower than morphine (2 mg kg-). The cocktail (400-1600 mg kg-) exhibited anti-inflammatory activity but inhibition observed at 1600 mg kg- in the 5 and 6 h was very significant. It compared favourably with the reference drug (Indomethacin 10 mg kg-). Consequently, it is our suggestion that the cocktail may possess analgesic and anti-inflammatory properties.
  A. Oloyede , J. Okpuzor and O. Omidiji
  The cytological and toxicological potentials of an ethanol extract of a decoction used in South Western Nigeria for the management of breast tumors were evaluated using mice and Allium cepa models. The oral administration of the extract to the mice within the range of 400-1600 mg kg-1 b. wt., dosage did not result in any mortality until 2000 mg kg-1 body weight (b. wt.), when 60% mortality occurred. The LD50 of the extract administered intraperitoneally, was 400 mg kg-1 b. wt. Furthermore, the extract induced macroscopic and microscopic changes causing a dose-related root growth inhibition and chromosomal aberrations in Allium cepa. The effect of the extract was more pronounced at 1600 mg kg-1, dose while the EC50 was at 380 mg after 72 h. This decoction may present cytological and toxicological potential for managing breast tumors and corroborates its use in ethno medicine.
 
 
 
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