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Articles by O. Lolodi
Total Records ( 3 ) for O. Lolodi
  G.E. Eriyamremu and O. Lolodi
  The growth pattern, chlorophyll content, lipid peroxidation as well as the activities of superoxide dismutase (SOD), Glutathione Peroxidases (GP) and catalase (CAT) were studied in the radicles, roots and shoots of Vigna unguiculata (the common beans) and Zea mays (maize) grown in soils contaminated with two nickel concentrations {0.1% (65 μM) and 0.2% (130 μM)}. Two hundred and seventy of either bean or maize seeds were germinated in these contaminated soils and 10 of each germinated plants were harvested after either the 7th, 14th and 21st days. The study observed chlorosis and stunted growth in the nickel-treated plants. Nickel accumulated in the tissues in increasing order of the radicle, root and the shoot. Treatment of the plants with 0.1% or 0.2% nickel did significantly (p<0.05) affected the activities of SOD, CAT and GP in the tissues studied throughout the experimental periods. Lipid peroxidation as measured by the production of malondialdehyde was significantly increased (p<0.05) in the plants grown on nickel-contaminated soils compared with the controls. These results indicate that nickel cause oxidative damage in Vigna unguiculata and Zea mays and as an adaptive feature, they increase the activities of antioxidant enzymes of the radicle, root and shoot.
  G.E. Eriyamremu , S.O. Asagba , V.E. Osagie , S.I. Ojeaburu and O. Lolodi
  This study reports the effect of unripe pawpaw and/or unripe plantain extracts on the phospholipid profile of the stomach and duodenum of normal rabbits. Supplementation of chow with unripe pawpaw or plantain extract significantly reduced (p<0.05) the weight gained by rabbits compared with the control. The total phospholipids content in the stomach and duodenum were significantly increased (p<0.05) in the test groups compared to the control. In the stomach and duodenum, phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SGM) were significantly increased (p<0.05) in the test groups compared to the control. Pawpaw occasioned a decrease in the PE/PC ratio in both tissues as against an increase observed in the SGM/PC ratio. The results presented suggests that unripe pawpaw meal and unripe plantain extract alter the phospholipid profile of the stomach and duodenum in ways which may affect membrane fluidity of these tissues and would have profound effect on the gastro-duodenal mucosa and thus have implication(s) for gastric and duodenal ulcers in rabbits.
  O. Lolodi and G.E. Eriyamremu
  This study investigated the effect of a methanolic extract of Vernonia amygdalina (VA) on lipid peroxidation and antioxidant status of the colon of rats maintained on a normal diet containing 5% Cycas revoluta (cycads). Fifty male Wistar albino rats were randomly assigned into five groups of ten experimental animals in a study that lasted for six weeks. One control group was maintained on a normal diet only while another group was fed a normal diet containing 5% cycads. The other three groups were maintained on the normal diet and 5% cycads and orally fed 200 mg VA/kg body weight for 1, 5 or 6 weeks. The results obtained revealed that the level of malondialdehyde (an index of lipid peroxidation) was significantly elevated (p<0.05) in rats exposed to cycads only compared with the control. However, oral administration of VA in conjunction with exposure to cycads appeared to reduce the extent of lipid peroxidation to values that are not significantly (p>0.05) different from those of the control. The activity of Superoxide Dismutase (SOD) was significantly reduced (p<0.05) in the experimental animals fed cycads compared with the controls. Oral administration of VA seemed to counteract the effect of cycads on SOD in the colon as no significant difference (p>0.05) was observed in rats fed VA compared with the controls. The results of this study suggest that methanolic extract of VA may mitigate the biochemical consequences of cycasin-induced lipid peroxidation in the colon of rats.
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