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Articles by O. Festus
Total Records ( 2 ) for O. Festus
  O.B. Idonije , O. Festus , O. Okhiai and U. Akpamu
  Malaria infection has been found to be associated with lipid peroxidation accompanying reduction in antioxidant capacity of the infected patients especially Plasmodium falciparum infection. In this study, a biomarker of lipid peroxidation, Malondialdehyde (MDA) was evaluated in adult (18-45 years) Nigerian patients with Plasmodium falciparum and Plasmodium vivax malaria infection. The research group is comprised of fifty patients with P. falciparum and fifty with P.vivax malaria confirmed patients attending the outpatient department of University of Benin Health Services Department, University of Benin, Benin City. Their lipid peroxidation products (MDA) values estimated spectrophotometrically were compared to that of the control group who are fifty apparently healthy tested malaria negative subjects. Result showed a significant increase (p<0.05) in Malondialdehyde level in malaria positive patients (n = 100; 7.67±0.42 μM L-1) compared to the control; malaria negative patients (n = 50; 4.43±0.32 μM L-1). This increase in Malondialdehyde level was higher in P.vivax malaria patients (n = 50; 7.94±0.27 μM L-1) than in P. falciparum malaria (n = 50; 7.41±0.38 μM L-1) and increases as the degree of parasitaemia increases. Malondialdehyde activity in malaria was higher in males than in females and among the young adults than in the old adults. The study specified malaria to induced oxidative stress which is higher in male and in the young and as the degree of parasitaemia increases and more severe with P.vivax malaria infection. Conclusively, supplementation of diet with antioxidants along anti-malaria drugs during treatment of malaria patients is recommended.
  B.O. Idonije , E.O. Nwoke , O. Festus and O.M. Oluba
  Malaria has protean clinical manifestations and Acute Renal Failure (ARF) is one of its serious complications and could be life threatening. Information on kidney involvement in malaria in Africa is still scanty and Nigeria is no exception. Kidney function was assessed in 60 (28 males and 32 females) malaria positive patients (as test subjects) and 40 (16 males and 24 females) malaria negative individuals (as controls) using plasma creatinine, urea and uric acid as test indicators. Descriptive analysis of results obtained showed that plasma creatinine level was significantly (p<0.05) increased in both males and females malaria positive patients (tests) compared to their respective controls (malaria negative males and females, respectively). Female test subjects also had significantly higher plasma urea concentration compared to female controls. No significant change (p>0.05) was observed in plasma uric acid between female test subjects and female control subjects. Similarly, plasma urea and uric acid levels were not significantly altered in male test subjects compared to male control subjects. Males test subjects were observed to have higher plasma levels of the test parameters compared to female test subjects. Comparative study between male and female test subjects showed significantly higher concentrations in plasma creatinine and uric acid in male test subjects compared to female test subjects. From these results, it is concluded that renal impairment is a clinical feature of malaria in Ekpoma, South-South Nigeria.
 
 
 
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