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Articles by O. Awodele
Total Records ( 3 ) for O. Awodele
  A. Akintonwa , O. Awodele , A.T. Olofinnade , C. Anyakora , G.O. Afolayan and H.A.B. Coker
  Problem statement: The pharmaceutical industry is a major contributor to industrial wastes globally. Effluents from this industry are usually discharged into the environment and when not properly handled and disposed, they affect both human health and the environment. Approach: This study evaluated the mutagenic potentials of effluents from six pharmaceutical companies in the Lagos province of Nigeria using modified Ames test and Allium cepa (Linn) assay. Allium cepa model was used to determine the mean root length, mitotic index and chromosomal aberrations effects of these plants on Onion bulbs using 5, 10 and 15% concentration of the pharmaceutical effluents. The modified Ames test which is a modification of the standard Ames test was done using E. coli (0157:H7) that has the phenotypic characteristics of glucose and lactose fermentation, motile, urease negative, indole positive and citrate negative. Result: From the results, two of the effluents showed mutagenicity with modified Ames test and all the six effluents showed mitodepressive and toxic effects to the Allium cepa root. Conclusion/Recommendations: It may then be recommended that pharmaceutical companies should devise means of containing, treating and managing their effluents.
  A.I. Oreagba , O.O. Aina , O. Awodele , S.O. Olayemi , A.F.B. Mabadeje and R.B. Ashorobi
  Grapefruit juice was assessed for chemoprophylactic activity against Chloroquine-sensitive Plasmodium berghei berghei infection in mice. A standard inoculum of 1x106 infected erythrocytes was used to assess the prophylactic effect of grapefruit juice (15 mL kg-1) and this was compared with the prophylactic effect of high dose Ascorbic acid (150 mg mL-1 or 2.25 g kg-1). The result of the experiment showed that grapefruit juice and high dose vitamin C significantly delayed the establishment of parasitaemia compared with the control group. Furthermore, grapefruit juice and ascorbic acid prolonged the mean survival time of the mice with corresponding decreases in mean peak percentage parasitaemia, respectively. Grapefruit juice however demonstrated a stronger chemoprophylactic activity than ascorbic acid (p<0.05). These effects were however lower than the standard prophylactic drug (Pyrimethamine-1.2 mg kg-1). Regular intake of grape juice may protect against malaria infection. Further studies are necessary to elucidate possible mechanisms involved.
  S.O. Olayemi , A.P. Arikawe , A. Akinyede , A.I. Oreagba and O. Awodele
  Mice are considered a comparable genetic model to humans and it is well established that mice also exhibit natural differences in susceptibility to malarial infection. The study aimed to determine and compare the effects of artesunate, artesunate+amodiaquine combination, amodiaquine and quinine on biochemical parameters such as liver catalase, plasma glutathione peroxidase, lipid peroxidation, total plasma proteins and plasma pH in the course of a malaria infection. Thirty male albino mice of eight weeks were randomly divided into 6 groups based on the specific antimalarial drug administered and two groups served as control and parasitized untreated groups respectively. The parasite used was a chloroquine-sensitive strain of Plasmodium berghei NK 65, inoculated into mice and observed for twelve days, followed by four days of antimalarial drug administration. Plasma sample was obtained and assay was done for lipid peroxidation, glucose concentration, plasma pH and liver catalase. Plasma pH was significantly lower (p<0.05) in the antimalarial groups compared to the Control and Parasitized untreated groups. Plasma glucose was significantly lower (p<0.05) in the parasitized untreated and antimalarial compared to the control group. Liver catalase was significantly higher (p<0.05) in the Parasitized untreated and antimalarial groups compared to the control group. Lipid peroxidation revealed different results within the antimalarial groups. Artemisinin and its combination with amodiaquine resulted in lowered plasma glucose and greater degree of lipid peroxidation, hence an index of suspicion should be put on possibility of hypoglycaemia with the use of ACTs.
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