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Articles by Nwodo Okwesili Fred Chiletugo
Total Records ( 2 ) for Nwodo Okwesili Fred Chiletugo
  Njoku Ugochi Olivia , Nwodo Okwesili Fred Chiletugo and Uroko Robert Ikechukwu
  Background and Objective:Ricinus communis seeds are widely consumed for nutritional and medicinal benefits. This study investigated the effects of Alkaloid-Rich Fraction (ARF) of methanol extract of Ricinus communis seed on inflammatory reactions, immune response and its hepatoprotective potentials on male wistar albino rats challenged with CCl4 in order to maximize its health benefits. Materials and Methods: In vitro study was employed in determining the effect of ARF on the hemolytic activity of complement proteins and immunostimulatory activity. The effects of ARF on immune response and hepatoprotective potentials were carried out using male Wistar albino mice and rats challenged with CCl4 in corn respectively. Results: The ARF of Ricinus communis seed caused significant (p<0.05) increase in the phagocytic index and stimulated phagocytosis in a concentration dependent manner when compared to the control. Complement protein activity significantly (p<0.05) increased hemolysis of the sensitized sheep red blood cells in a concentration-dependent manner when incubated in the ARF indicating that the ARF could be used in prevention of infections associated with complement protein deficiency. A dose dependent significant decrease (p<0.05) in the delayed type hypersensitive response was observed while significant increase (p<0.05) in the primary and secondary antibody titers of the test groups relative to normal control were also observed. However, there was significant decrease (p<0.05) in both primary and secondary titer values when compared to the standard control that received 2.5 mg kg–1 of levamisole. At higher dose of the ARF, aspartate aminotransferase activity significantly (p<0.05) increased when compared with the control. In addition, alanine aminotransferase and alkaline phosphatase activities of the treated groups significantly decreased (p<0.05) when compared to positive control indicating that the ARF could maintain liver integrity and functions. Conclusion: The findings of this study suggest that the ARF has hepatoprotective potentials and positive effects on immune system coupled with potentials anti-inflammatory activity that could help the body defense system, fight diseases and pathogenic organisms.
  Ojogbane Eleojo , Daikwo Moses Alilu and Nwodo Okwesili Fred Chiletugo
  Several literatures exist on the efficacy of Cyphostemma glaucophilla in the treatment of diverse ailment ranging from malnutrition disorders to systemic diseases such as hypertension and kidney problems. Effect of aqueous leave extract of Cyphostemma glaucophilla was investigated on Carbon tetrachloride induced hepatotoxicity by evaluating its biochemical activities on Aspartate Amino Transferase (AST), Alanine Amino Transferase (ALT), Alkaline Phosphatase (ALP), Bilirubin and creatinine. The negative control group A were served daily doses of saline (0.85% NaCl; 5 mL kg-1) positive control group B received (0.85% NaCl; 5 mL kg-1 and a single concentration 5 mL kg-1 of CCl4) while groups C, D, E and F were given 5.0, 10.0, 15.0, 20.0 mg kg-1 body weight of extract using stomach tubes for 7 days, respectively. CCl4 (5 mL kg-1) single concentration was administered to groups B, C, D, E and F on the 8th day however, extract administration continued for groups C, D, E and F on day 9 and 10. The activities of the enzyme markers in the positive control group were observed to increase significantly (p<0.05) when compared with the negative control and the test groups C, D, E and F. The test groups administered varying doses of extract after exposure to CCl4 decreased significantly (p<0.05) and in a dose dependent manner the activities of ALT, AST and ALP. There was also a significant (p<0.05) dose dependent decrease in the level of unconjugated, conjugated bilirubin and creatinine. It is observed, that Cyphostemma glaucophilla among its numerous pharmacological properties may serve as a cheap alternative in maintaining liver and kidney disorders.
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