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Articles by Nweje-Anyalowu Paul Chukwuemaka
Total Records ( 2 ) for Nweje-Anyalowu Paul Chukwuemaka
  Uroko Robert Ikechukwu , Agbafor Amarachi , Uchenna Oluomachi Nancy , Achi Ngozi Kalu , Egba Simeon Ikechukwu , Nweje-Anyalowu Paul Chukwuemaka and Ngwu Ogochukwu Rita
  Background and Objective: Local consumers of whole palm fruit extract claim that it is rich in nutraceutical properties. This claim has not been validated as there is no scientific evidence or data to take back up. This study was designed to investigate in vitro antioxidant activity of the aqueous extracts of palm fruits and their effects on the antioxidant parameters of male Wistar albino rats with a view of improving human health. Materials and Methods: The acute toxicity study was carried out with 18 male Wistar albino mice while 45 male Wistar albino rats were used for the study of the effects on antioxidant parameters. The rats were grouped into 5 groups: Group 1 serving as normal control and received 2 mL kg–1 b.wt., of normal saline. Five rats each in group 2-5 received 100, 200, 400 and 600 mg kg–1 b.wt., of the fresh and fermented extracts of palm fruits respectively for 28 days and the rats were sacrificed on the day 29. The data obtained were statistically analyzed using one way analysis of variance and t-test. Results: The aqueous extracts were relatively safe as their administration resulted to no death or adverse reactions. The extracts possess high total antioxidant capacity, ferric reducing antioxidant power and effectively inhibited lipid peroxidation depicted by low concentrations of thiobarbituric acid and malondialdehyde. In addition, the extracts exhibited a dose dependent increase in percentage inhibition of 1,1-Diphenyl-2-picrylhydrazyl radicals. The extracts caused a dose dependent significant (p<0.05) decrease in catalase activity and significant increase in superoxide dismutase activity of all the rats administered the extracts. Whereas, the fermented extract administration led to significant (p<0.05) dose dependent increase in myeloperoxidase and glutathione peroxidase activity in the rats, the fresh extract caused significant (p<0.05) decrease in myeloperoxidase and glutathione activity of group 2 rats and a dose dependent increase in groups 3-5. Conclusion: These findings suggest that the extracts possess antioxidant properties which could effectively prevent oxidative stress, lipid peroxidation, ameliorate damage and associated health consequences resulting from activity of excess free radicals, if taking in adequate concentration.
  Uroko Robert Ikechukwu , Egba Simeon Ikechukwu , Achi Ngozi Kalu , Uchenna Oluomachi Nancy , Agbafor Amarachi , Ngwu Ogochukwu Rita , Nweje-Anyalowu Paul Chukwuemaka and Ogbonna Chisom Esther
  Background and Objective: There is increase in the rate of consumption of aqueous extracts of ripe palm fruits (Elaeis guineensis) by humans in their daily diets but there is little or no toxicological data to support the safety of their consumption. This study investigated the effects of aqueous extracts of palm fruits on liver function indices of male Wistar albino rats with the view of understanding the hepatotoxic potentials of the extracts. Materials and Methods: Acute toxicity study was carried out with 18 male Wistar albino mice. Liver function indices were evaluated using 45 male Wistar albino rats and by following standard analytical protocols. The rats were divided into 5 groups with group 1 having 5 rats only and group 2-5 had 10 rats each. Group 1 rats were the normal control that received 2 mL kg–1 b.wt., of normal saline. Five rats each from group 2-5 received 100, 200, 400 and 600 mg kg–1 b.wt., of the fresh and fermented aqueous extracts of palm fruits, respectively for 28 days. Data was analyzed by one way ANOVA using SPSS. Results: The aqueous extracts were relatively safe as no death or adverse reactions were observed in the mice in 24 h after administration. There were significant (p<0.05) dose-dependent increase in all the liver marker enzymes assayed in all the groups administered the aqueous extracts when compared with the normal control. Total protein concentrations of groups 2 and 3 that received low doses of the fresh aqueous extract of palm fruit decreased significantly (p>0.05) when compared to the normal control. However, groups 4 and 5 that received higher doses of the fresh extract showed significant (p<0.05) increase in total protein and bilirubin concentrations when compared to the normal control. A significant (p<0.05) decrease in albumin concentrations was observed when the extracts were administered to the rats in higher doses, respectively when compared to the normal control. Conclusion: The findings suggest that the fresh and fermented aqueous extracts of palm fruit have little or no toxic effects on liver integrity and functions at very low concentration, however, it could cause significant chronic toxic effects on liver integrity and functions at higher concentrations.
 
 
 
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