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Articles by Nuria De Pedro
Total Records ( 2 ) for Nuria De Pedro
  Nuria De Pedro , Bastien Cautain , Juan Cantizani , Lorena Rodriguez , Francisca Vicente , RatnaTualsi and Sundar Rao Koyyalamudi
  Background: The mitochondrion is an essential organelles for producing most of the energy in the cell and also involved in a number of cellular activities in the cell. It plays an important role in the aging process. Mitochondrial dysfunctions are supposed to be responsible for many neurodegenerative diseases as Alzheimer’s Disease (AD), Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS). A growing body of evidence suggests that defects in mitochondrial metabolism and particularly of electron transport chain may play a role in neurodegenerative diseases. Secondary effects as proapoptotic factors and Reactive Oxygen Species (ROS) can be an early stage of several mitochondrial disorders. Objective: To evaluate the mitochondrial membrane potential, ROS generation, GSK-3β and CK-1δ activities of seven natural products (isoquercetin, rutin, avicularin, hesperetin, astragalin, luteolin and diosmin) by using well established assays in vitro assays. Materials and Methods: In this study, neuroprotective effect of seven natural products on rotenone-induced toxicity in a SH-SY5Y neuroblastoma cells model for PD. Results: In this study, seven natural products were assessed the mitochondrial membrane potential, ROS generation, GSK-3β and CK-1δ activities using well established assays. The most effective compound to prevent mitochondrial membrane depolarization and decrease the ROS levels was luteolin followed by isoquercetin and astragalin. Isoquercetin, astragalin, hesperetin and rutin have good activity against GSK-3β and no activity against CK-1δ. Conclusion: This study results suggest that isoquercetin and astragalin exerts its neuroprotective effect against rotenone due to its mitochondrial membrane potential, ROS generation, GSK-3β and CK-1δ activities.
  Lin Zhang , Cheang Soo Khoo , Sundar Rao Koyyalamudi , Nuria de Pedro and Narsimha Reddy
  Background and Objective: It is evident from the scientific literature that plant and mushroom polysaccharides possess significant antioxidant, immunomodulatory and anticancer activities. Sixteen traditional Chinese anticancer herbs were evaluated for the immunomodulatory and anticancer potential of their polysaccharides. This study also aimed to correlate the bioactivities of these polysaccharides with their monosaccharide composition and to identify the best herbs for further detailed studies. Methods: Polysaccharides were extracted from the selected traditional Chinese medicinal (TCM) herbs and their biological activities examined. The antioxidant activities were examined using DPPH scavenging, ABTS∙+ scavenging and iron chelating assays. The immunomodulatory properties of the polysaccharides were determined by evaluating their capacity to activate mouse macrophages (RAW 264.7) to produce the cytokines, namely, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). The anticancer activities of the polysaccharides were determined against five human cancer cell lines. Cell viabilities were evaluated by the MTT test to assess the toxicities of these polysaccharides. The total sugar content and the monosaccharide composition of the polysaccharides were determined with a view to correlate their bioactivities with chemical constituents. All data were analyzed using ANOVA and Duncan’s multiple range methods. Results: The polysaccharides isolated from Artemisia annua L., Lobelia chinensis Lour, Amauroderma rugosum (Blume and T. nees), Artemisia scoparia Waldst. and Kit, Artemisia vulgaris L., Curcuma aromatic Salisb, Rheum palmatum L. and Cyperusrotundus Blanco showed significant anticancer, immunomodulatory and antioxidant activities with low toxicity. The results suggested that the polysaccharides extracted from A. annua, L. chinensis, A. rugosum and S. suberectus have strong potential for immunotherapy and hence suitable candidates for cancer treatment. Conclusion: Polysaccharides from several herbs were found to exhibit significant antioxidant, immunostimulatory and anticancer activities. The results demonstrated that, A. annua, L. chinensis and A. rugosum and S. suberectus are highly suitable herbs for the discovery of anticancer polysaccharides.
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