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Articles by Norimah Yusof
Total Records ( 2 ) for Norimah Yusof
  Yam Mun Fei , Jamaludin Zainol , A. G. Pillay and Norimah Yusof
  In this research work, 30 albino rats were tested to evaluate the effectiveness of lyophilized Aloe vera dressing on wound healing process. The treatments were applied on the deep partial thickness burn wounds that were induced by modified electric solder. Three rats from each group were euthanatized on day 5, 10, 15, and 20 for tensile strength investigation. Another three rats were randomly selected from each group to be euthanatized on 24 hours (day 0) post-burn to determine the level of damage by histological study. Generally, the tensile strength increased on day 5 and 10 because of fibroblast activity and decreased on day 15 and 20 due to the rearrangement of the collagen. However, there is no significant difference (P<0.05) in the tensile strengths of both treated and control groups. The treated groups healed faster as compared to the control. The lyophilized Aloe vera dressing showed scar formation after 7 to 10 days of post-burn, and control showed scarring after 8-12 days of post-burn. However, all the wounds did not show any sign of infection, and no pustule was observed during the experimental period. Epithelialisation was observed in lyophilized Aloe vera dressing on day 5 and almost completed on day 10, whereas the control group showed signs of epithelialization only on day 15 and completed on day 20.
  Wong Siew Tung , Jamaludin Zainol , A. G. Pillay , Norimah Yusof and Loqman Mohamad Yusof
  The repair of large abdominal wall defects remains a complex surgical problem of insufficient autogenous tissue for adequate abdominal wall closure. The aim of this investigation was to investigate the effectiveness of processed bovine tunica vaginalis, as a biomaterial in repairing such large abdominal wall defects. The rats are used as an experimental models. Twenty-four adult laboratory rats were randomly divided into two equal groups. In the treated group, an abdominal wall defect was created in each animal and then repaired with processed bovine tunica vaginalis. In the control group, a midline incision was made at the abdominal wall muscle and then closed with suture. Macroscopic examination of the abdominal wall showed that there was no evidence of herniation, seroma and distortion of the grafts. Adhesion between the biomaterial and the greater omentum was observed in all animals, but there was no adhesion to the underlying visceral organs. The inflammatory response gradually decreased by time. The biomaterial incorporated in the host tissue by the ingrowth of both collagenous and muscular tissues, and also by the formation of blood vessels and peritoneal lining. This investigation showed that the processed bovine tunica vaginalis can be used as an effective biomaterial to repair large abdominal wall defects.
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