Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by Nong Tang
Total Records ( 1 ) for Nong Tang
  Li-Chun Zhao , Ying Liu , Zi Wang , Nong Tang , Jing Leng , Bing Zheng , Ying-Ying Liu and Wei Li
  Background and Objective: Platycodi Radix (PR), a famous traditional medicine and folk food, has been used in China. PR exerted numerous pharmacological activities including anti-tumor, anti-obesity and anti-inflammation. The present study aimed to investigate the active constituents by Liquid Chromatography/Mass Spectrometry (LC/MS) analysis and protective effects of saponins from the steamed Platycodi Radix (SSPR) on acute alcohol-induced liver injury in mice. Materials and Methods: Pretreatment with SSPR (100, 200 and 400 mg kg–1) prior to alcohol administration significantly prevented the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and triglyceride (TG) in serum, malondialdehyde (MDA) level in liver tissue compared with the alcohol group (p<0.05). Results: The level of enzymatic antioxidants glutathione (GSH) was increased noticeably (p<0.05) in SSPR pretreatment mice liver tissue. Histopathological examination revealed that pretreatment with 400 mg kg–1 of SSPR markedly ameliorated acute alcohol-induced hepatocyte apoptosis and fatty degeneration. The findings from LC/MS analysis indicated that SSPR had more saponins than unheated-processed one and SSPR mainly contain a polyacetylene (Lobetyolin) and 22 saponins. Conclusion: These results showed the beneficial effect of SSPR on acute alcohol-induced oxidative stress and liver damage.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility