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Articles by Nivedita Nanda
Total Records ( 2 ) for Nivedita Nanda
  Nivedita Nanda , Zachariah Bobby and Abdoul Hamide
  Hypothyroidism is among the most common endocrine disorders in India. One of the most frequent causes of hypothyroidism is the autoimmune thyroid disease characterized by elevated Anti-thyroperoxidase Antibody (TPO Ab). We reported earlier the presence of Oxidative Stress (OS) in hypothyroid patients. In this study, we compared the level of OS in TPO Ab positive hypothyroid patients with TPO Ab negative hypothyroid patients which earlier has not been studied. We recruited untreated hypothyroid patients consecutively from the out patient department. We analyzed their TPO Ab titer, various biochemical and oxidative stress parameters and ultra-sensitive C reactive protein. The thiobarbituric acid reactive substances, an indicator of oxidative stress was significantly higher in TPO Ab positive hypothyroid patients compared to TPO Ab negative cases. TPO Ab titter positively correlated with the OS parameters and extent of low grade inflammation in TPO Ab positive hypothyroid patients. Oxidative stress was found to be more in TPO Ab positive untreated hypothyroid patients in our study indicating that autoimmunity could be one of the mechanisms contributing to the elevated OS level in hypothyroidism.
  Nivedita Nanda , Zachariah Bobby and Abdoul Hamide
  Hypothyroidism and Diabetes mellitus are among the most common endocrine disorders in India. Oxidative stress has been proposed to be one of the causative factors associated with insulin resistance. In our previous study, we reported the presence of oxidative stress in hypothyroidism. However, the link between oxidative stress and the status of insulin resistance in hypothyroidism has not been addressed yet especially among the Indians. We recruited sixty seven untreated hypothyroid patients consecutively from the out patient department and analyzed their homeostatic model assessment of insulin resistance (HOMA-IR) and oxidative stress parameters. Oxidative stress parameters and HOMA-IR were significantly higher compared to euthyroid controls. The severity of disease, body mass index and altered lipid profile, glycated hemoglobin and MDA levels were significantly associated with insulin resistance. However, only glycated hemoglobin and MDA levels were found to be independent predictors of HOMA-IR in these patients. Increased OS could be one of the mechanisms for mild insulin resistance as reported in our study in untreated hypothyroid patients.
 
 
 
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