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Articles by Nisha Sharma
Total Records ( 2 ) for Nisha Sharma
  Nisha Sharma , Prakash Chandra Gupta and Chandana Venkateshwar Rao
  Diabetes mellitus is a metabolic disorder of endocrine system. This dreadful disease is found all over the world and is becoming a serious threat to the mankind health. Alternative to synthetic agents, plants provide a potential source of hypoglycemic drugs. The aim of the present study was to evaluate the hypoglycemic effect of 70% alcoholic extract of Pentapetes phoenicea (PPE) on blood glucose level in glucose loaded, normal and experimentally induced diabetic rats. Based on the acute toxicity test, two variable doses (250, 500 mg kg-1 b.wt.) of hydro-alcoholic extract of P. phoenicea leaves were compared with glibenclamide for the influence on fasting blood glucose in glucose loaded, normoglycemic and streptozotocin (STZ) (55 mg kg-1, i.p.) induced hyperglycemic rats. All the statistical comparisons were made by one-way analysis of variance (ANOVA) followed by Newman-Keuls Multiple Comparison Test using Graph Pad Prism 4.01 v for windows (Graph Pad Software, San Diego, CA, USA). The difference showing a p level of 0.05 or lower was considered to be statistically significant. The administration of PPE in two doses and glibenclamide (5 mg kg-1) to STZ induced hyperglycemic animals significantly lowered the blood glucose levels with 18.84% (p<0.01) for PPE 250 mg kg-1 and 38.89% (p<0.001) for PPE 500 mg kg-1 in a dose dependant manner. Considering all the results obtained, the study concludes that the hydro-alcoholic extract of P. phoenicea leaves produced promising decrease in blood glucose levels in STZ induced hyperglycemic rats which might be related to tannins, terpenoids, sterols and flavonoid contents.
  Nisha Sharma , P.C. Gupta and Ch.V. Rao
  This study discusses the nutrient composition and the nutraceutical importance of green leaves and wild gathered foods in an area with surplus food production in Kanpur. The study presents a nutrition composition and antioxidant activity of Amaranthus viridis whole herb and Moringa oleifera leaves for their nutraceutical value. Levels of some nutrients in Moringa oliefera leaves and Amaranthus viridis whole herb were determined using standard analytical methods. In M. oleifera leaves, crude protein was 20.51%, crude fiber 19.25%, crude fat 2.63%, ash content 5.13%, moisture content 71.73%, carbohydrate content 43.78% and the calorific value 430.41 kcal. For A. viridis crude protein was 2.11%, crude fiber 1.93%, crude fat 0.47%, ash content 1.85%, moisture content 87.90%, carbohydrate content 7.67% and the calorific value 43.35 kcal. The elemental analysis of the leaves in mg/100 g dry matter (DM) reveals the calcium and iron content of M. oleifera 2007.67 and 26.34, respectively. Leaves of A. viridis contained Calcium 330 mg/100 g, Fe 18.2, Mg 1842, P 52, K 3460, Na 108, Zn 10, Cu 300, Mn 8, Se 1.98 and Cr 0.92 mg. The antioxidant activity, IC50 μg mL-1 (DPPH method) of M. oliefera leaves and A. viridis herb was found to be 49.86 and 28.92, respectively. The study concludes that selected plant samples are an important source of proteins, crude fiber, carbohydrates, energy and minerals. The plants contain an appreciable amount of nutrients and can be included in diets to supplement our daily nutrient needs and to fight against many of the diseases as nutraceuticals.
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