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Articles by Nisha Devi
Total Records ( 3 ) for Nisha Devi
  Nisha Devi and H.S. Banyal
  Immunity to malaria can be induced by experimental infection in rodents. A large number of malaria antigens have been identified having their role in protective immune responses to malaria. In this study, mice immunized with soluble antigens of 24,000 g sedimented fraction exhibited strong humoral immune response and this was evaluated by serodiagnostic assays. When 24,000 g fraction were subjected to SDS-PAGE, showed protein bands with molecular weights ranging from 24-80 kDa. It appears that some of these proteins act as target antigens. The immune sera obtained from immunized mice were subjected to ELISA, IFA and in vitro invasion inhibition assay. The antibody titres ranged from 1:2048-1:16384 in immune sera.
  H.S. Banyal , Rani and Nisha Devi
  Different parts of Picrorhiza kurrooa (Kutki) were used to evaluate their antimalarial effect against Plasmodium berghei in vivo in a typical 4 day test. Experimental groups of mice were administered with ethanol extracts of roots and leaves of Picrorhiza kurrooa. On day 4 parasitaemia in control group of mice was 23.15±1.66 whereas, groups treated with roots and leaves extract of P. kurrooa resulted in inhibition of malaria parasite significantly and parasitaemia being 4.14±1.70 and 11.4±1.66, respectively. The effect of root extract was more pronounced compared to leaves.
  H.S. Banyal , Vanita Devi and Nisha Devi
  Extracts of roots and leaves of Centella asiatica (Linnaeus) Urban were used to evaluate their antimalarial effect against Plasmodium berghei in vivo in a typical 4 day test. Alcohol soluble extracts were administered orally in experimental mice along with placebo controls. On day 4 parasitaemia in control group of mice was 21.54±1.75% while in mice treated with roots and leaves extracts showed 5.73±1.14% and 11.89±1.25% infection, respectively.
 
 
 
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