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Articles by Ning Wang
Total Records ( 6 ) for Ning Wang
  Ning Wang , Linlin Geng , Shucheng Zhang and Jiedong Wang
  The aim of this study was to explore the temporal and spatial relationship among pinopodes, implantation sites and implantation window and to suggest a method to obtain a sufficient number of pinopodes for further study. The endometrium was divided into two groups: the natural pregnancy group and the pseudopregnancy group. The distribution and density of pinopodes in different phases were observed by scanning electron microscopy in order to determine the phase and location that pinopodes enriched on the surface of endometrium. In the natural pregnancy group, a small number of tiny and round pinopodes started to protrude on the endometrial surface from day 3.5 of pregnancy. On day 4.5, a large number of pinopodes protruded from the endometrial surface, concentrating in where the implantation sites were located. On day 5.5, pinopodes started to regress. Pinopodes reached their peak at the implantation sites on the phase of implant window. In comparison, in the pseudopregnancy group, pinopodes reached their largest scale and density on day 3 of pseudopregnancy and earlier than they were in the natural pregnancy group. Pinopodes concentrated in the crypts of anti mesometrial side. In the natural pregnancy group, the peak of pinopodes appeared temporal and spatial coincident with implantation sites and implantation window. In the pseudopregnancy group which was earlier than they were in the natural pregnancy group. Whether in the natural pregnancy group or in the pseudopregnancy group, researchers can obtain endometrium containing pinopodes without interference of other tissues containing none or scarce pinopodes. This makes it possible to better understand the biochemical characteristic of pinopodes by studying biological molecules in pinopodes. This also helps to further explain the mechanism of recognition in other words, the relationship between the maternal endometrium and embryo in the process of apposition and attachment during the early implantation.
  Shen He , Chong Feng , Chuan Long , Hongmei Pan , Ning Wang , Ningning Shi , Fei Wang , Yanrong Zhou , Hongxing Chen , Mingxing Chu , Dengke Pan and Xuewei Li
  The development of α-1,3-galactosyltransferase gene knockout pigs along with overexpression of human Complement Regulatory Proteins (hCRPs) has been an important step in overcoming hyperacute rejection when pig organs are transplanted into nonhuman primates. Most previous studies have used commercial pigs as organ donors. However, little has been reported about the use of inbred miniature pigs as genetic donors expressing hCRPs. As expression of hCRP on the surface of pig cells, especially human membrane cofactor protein (hCD46) could effectively protect them against human complement-mediated rejection, researchers constructed an engineered hCD46 minigene expression vector and generated transgenic Wuzhishan miniature Pigs (WZSP) expressing hCD46. Expression of hCD46 with a distinct tissue-specific pattern similar to the human one was observed using immunohistochemistry. Various tissues revealed strong immunostaining in most epithelial tissues and vascular endothelium. Flow cytometry analysis of hCD46 porcine AECs showed expression levels similar to human AECs. Complement-mediated cytolysis of transgenic porcine Aortic Endothelial Cells (AECs) with human serum showed significant protection. Distinct differences between ABO blood groups were also observed with much less cytolysis of porcine AECs treated with B blood group serum than with other serum types. In conclusion, transgenic WZSPs with sufficient expression of hCD46 have been established successfully and will facilitate further xenotransplantation research.
  Ning Wang , Shan-Tang Yue and Ying-Liang Liu
  A new lanthanide complex K[Gd(ox)(SO4)(H2O)] (1) with sulfate and oxalate ligands has been synthesized under hydrothermal conditions. The compound crystallizes in the monoclinic space group P21/c with a = 6.5849(1) Å, b = 8.5660(1) Å, c = 14.7660(2) Å, β = 112.470(1)°, C2H2GdKO9S, M = 398.46, Z = 4, V = 769.66(2) Å3, F(000) = 740, R1 = 0.0199 and ωR = 0.0514. The solid-state DC magnetic susceptibility measurements of 1 revealed antiferromagnetic behavior with an S = 7/2 ground spin state.
  Hong-Yan Wu , Ning Wang , Shan-Tang Yue and Ying-Liang Liu
  Two 2-D metal carboxylate coordination compounds [Tb(pydc)(ox)1/2(H2O)2] (1) and [Cd(pydc)(me)(H2O)]2 · H2O (2) (pyridine-2,5-dicarboxylic acid = pydc, oxalic acid = ox, me = methanol) have been synthesized under hydrothermal conditions. Carboxylates are building blocks in the formation of zigzag chain and cockle stair-like chain structures for 1 and 2, respectively. Both the compounds have been structurally determined by single-crystal X-ray diffraction, and characterized by elemental analysis, infrared spectroscopy, thermogravimetric analysis, and fluorescence spectra.
  Hong-Yan Wu , Shan-Tang Yue , Ning Wang and Ying-Liang Liu
  Two isostructural 3-D complexes [Ln(pdc)(ox)0.5(H2O)2]⋅H2O (Ln = Tb(1), Eu(2); pdc = 3,5-pyrazoledicarboxylate; ox = oxalate) have been synthesized under hydrothermal conditions. Both are characterized by single crystal X-ray diffraction, elemental analysis, and IR. Compounds 1 and 2 possess a 3-D framework with 1-D rectangular channels built from 2-D, brick-like networks, and pdc ligands. The photoluminescence and lifetimes of 1 and 2 in the solid state have been studied.
  Ning Wang , Emily J. Glidden , Stephanie R. Murphy , Bradley R. Pearse and Daniel N. Hebert
  The earliest steps in nascent protein maturation greatly affect its overall efficiency. Constraints placed on maturing proteins at these early stages limit available conformations and help to direct the native maturation process. For type II membrane proteins, these cotranslational constraints include N- and C-terminal membrane tethering, chaperone binding, and disulfide bond formation. The cotranslational maturation process for the type II membrane glycoprotein influenza neuraminidase (NA) was investigated to provide a deeper understanding of these initial endoplasmic reticulum events. The type II orientation provides experimental advantages to monitor the first maturation steps. Calnexin was shown to cotranslationally interact with NA prior to calreticulin. These interactions were required for the efficient maturation of NA as it prematurely formed intramolecular disulfides and aggregated when calnexin and calreticulin interactions were abolished. Lectin chaperone binding slowed the NA maturation process, increasing its fidelity. Carbohydrates were required for NA maturation in a regio-specific manner. A subset of NA formed intermolecular disulfides and oligomerized cotranslationally. This fraction increased in the absence of calnexin and calreticulin binding. NA dimerization also occurred for an NA mutant lacking the critical large loop disulfide bond, indicating that dimerization did not require proper NA oxidation. The strict evaluation of proper maturation carried out by the quality control machinery was instilled at the tetramerization step. This study illustrates the type II membrane protein maturation process and shows how important cotranslational events contribute to the proper cellular maturation of glycoproteins.
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