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Articles by Nilgun TURHAN
Total Records ( 3 ) for Nilgun TURHAN
  Nilgun TURHAN , Aslıhan PEKEL , Yuksel ONARAN , Zehra Candan ILTEMIR DUVAN and Omer BAYRAK
  Aim: To compare the motility yields of single or double wash after density gradient centrifugation of the ejaculate and their effects on pregnancy rates in clomiphene citrate induced intrauterine insemination (IUI) cycles. Materials and methods: This prospective randomized controlled study included 341 IUI cycles. Sperm specimens processed by density gradient centrifugation either with single wash (the single wash group, n = 170) or double wash treatment (the double wash group, n = 171). Sperm parameters before and after the preparation and the cycle outcomes were evaluated. The main outcome measure was the pregnancy rate. Results: The prewash sperm concentrations, the total motile sperm count, sperm motility and the mean percentage of normal sperm morphology of the groups were similar (P > 0.05). Post-wash sperm concentrations and inseminated motile sperm concentrations were similar in both groups (P > 0.05). Post-wash fast progressive motility (+4 motility) was significantly higher in the double wash group compared to the single wash group (P = 0.017). A total of 62 (18%) clinic pregnancies were obtained in 341 treatment cycles. Clinical pregnancy rate per insemination cycle was 11.8% for the single wash group and 24.6% for the double wash group (P = 0.003). Conclusion: Double wash treatment after density gradient centrifugation of the ejaculate yields a better post-wash fast progressive sperm motility and higher IUI pregnancy rate after ovarian stimulation with clomiphene citrate.
  Nilgun TURHAN , Aslihan PEKEL , Aylin AYRIM and Omer BAYRAK
  Aim: To investigate the association between prewash progressive sperm motility and pregnancy rate in cases of severely oligoasthenozoospermic patients in intracytoplasmic sperm injection (ICSI) cycles. Materials and methods: The study included 80 infertile couples who were treated by ICSI due to severe oligoasthenozoospermia (<106). Results were obtained by retrospective analysis of data that are regularly entered into SPSS in our In Vitro Fertilization Unit. Female patients older than 35 years were excluded. The patients were divided into 2 groups according to prewash progressive sperm motility. Group I had progressive sperm motility below 10% (n = 40), and group II had progressive sperm motility equal to or greater than 10% (n = 40). The main outcome measure was the clinical pregnancy rate. Results: The patient characteristics were similar in both groups. There were no significant differences between the 2 groups in terms of total number of oocytes retrieved, number of mature oocytes, fertilization rate, or the number of transferred embryos. A total of 38 (47.5%) clinical pregnancies were obtained in 80 ICSI treatment cycles. The clinical pregnancy rate was significantly higher in group II (62.5% [25/40] than in group I (32.5% [13/40]), with P = 0.014. Conclusion: Severe sperm motility impairment results in human infertility, which can be overcome by ICSI. The data from this study demonstrated that severe progressive motility defects in cases of severe oligoasthenozoospermia do not prevent fertilization or normal embryo production in ICSI cycles; however, the rate of ICSI success may be influenced by progressive sperm motility. Our results show that oligoasthenozoospermic patients with progressive sperm motility above 10% have better clinical pregnancy results.
  Nermin KOSUS , Aydin KOSUS and Nilgun TURHAN
  Aim: To compare the mean platelet volume (MPV) of pregnant women with mild glycemic disorders with that of healthy pregnant women to find whether these disorders are risk factors for future cardiovascular disease. Materials and methods: Fasting blood glucose and 50-g oral glucose loading were measured. A 100-g, 3-h oral glucose tolerance test was done when plasma glucose was ≥140 mg/dL, following a loading test. According to the test results, 4 groups were formed: control, impaired fasting glucose, false positive loading test, and impaired glucose tolerance. The hematologic parameters were compared in all of the groups. Results: The mean MPV of the control group was lower than those of the other groups. The MPV had high sensitivity in prediction of the false positive loading test (sensitivity: 70.0%, specificity: 55.2%, AUC = 0.602, P = 0.029) and impaired glucose tolerance (sensitivity: 73.1%, specificity: 46.1%, AUC = 0.621, P = 0.009), although its sensitivity was lower than the others in prediction of impaired fasting glucose (sensitivity: 60.7%, specificity: 58.2%, AUC = 0.558, P = 0.374). Conclusion: Mild glycemic disorders are associated with increased MPV. Increased MPV might be associated with elevated baseline cardiovascular risk factors. Individuals with these glycemic disorders might be more aggressively targeted with strategies to lower cardiovascular disease risk.
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