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Articles by Nighat Sultana
Total Records ( 3 ) for Nighat Sultana
  Atta- Ur-Rahman , Nighat Sultana , Durre Shahwar and Muhammed Iqbal Choudhary
  Investigation of roots of Rhazya stricta (Apocynanaceae) of Pakistan origin lead to isolation of two new fatty esters 9-octadecenoic acid-2`,3`-dihydroxy propyl ester (1) and hexadecanoic acid-2`,3`-dihydroxy propyl ester (2). Linked scan MS measurements were used to propose a mass fragmentation pattern for the fatty ester 9-octadecenoic acid-2`,3`-dihydroxy propyl ester.
  Nighat Sultana and Asaad Khalid
  A new triterpenoid 3α-hydroxy-ursane-5-ene (1) and a known steroid stigma sterol (2) have been isolated for the first time from the fruit of Rhazya stricta. The structures of these compounds were elucidated and identified by spectral studies. The crude ethanolic extract of R. stricta fruit has led to the determination of good results of antibacterial, lipoxygenase and acetylcholinesterase activities. In addition, we also reported the acetylcholinesterase activity of stigma sterol (2) isolated from this plant. Stigma sterol (2) was found to be an acetyl-cholinesterase inhibitor with IC50 at a concentration of 644.0 ± 11.75 µM. Eserine [(-)-physostigmine, IC50 = 61 nM)] was used as a positive control.
  Nighat Sultana , Musarrat Akhter and Zakia Khatoon
  Studies on the aerial parts of Rubus niveus yielded six known compounds, 3,5-dihydroxy benzoic acid C7H6O4, (1), gallic acid C7H6O5 (2), ethyl galactoside (3), oleanolic acid (4), β-sitosterol (5) and 3-O-[β-D-galactopyranosyl-(12)-D-glucopyranoside (6). Besides this, a gallic acid derivative with methyl substitution was synthesised as tetramethyl gallate (3). Together with this derivative, compounds 1, 2, the alcohol soluble, chloroform soluble and petroleum ether soluble extracts of the aerial parts of R. niveus were screened for its nematicidal activity against freshly hatched second stage juveniles of Meloidogyne incognita (root-knot nematode), exhibiting 100, 94, 100, 52, 45 and 14% mortality, respectively of M. incognita after 48 h at 0.5% concentration. Compounds 1, 2 and 3 were found to be more potent than the nematicide Azadirachta indica at the same concentration. Negative results were obtained for nematicidal activity of the petroleum ether extract of R. niveus leaf extract. This is the first report on the isolation of chemical constituents as well as the nematicidal activity of compounds and any part of R. niveus.
 
 
 
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