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Articles by Neeru Vasudeva
Total Records ( 3 ) for Neeru Vasudeva
  Neeru Vasudeva , Prerna Singla , Sneha Das and Surendra Kumar Sharma
  The present study was aimed at investigating the antioxidant and antigout activity of the various extracts of the stem and root of Origanum majorana Linn. The antioxidant activity of ethanol extracts of both stem and root of marjoram was evaluated by various in vitro antioxidant assays. The ethanol extracts of stem and root showed potent antioxidant activity in all models when compared with ascorbic acid having IC50 values 21.05 μg mL-1 and 84.98 μg mL-1 for DPPH (2, 2-diphenyl-picrylhydrazyl); 492.8 μg mL-1 and 477.6 μg mL-1 for H2O2 radical scavenging assay; 156.9 and 141.79 μg mL-1 for metal chelating assay, respectively. The reducing ability of root ethanol extract (absorbance 0.747±0.23) was found to be high, compared to stem ethanol extract (0.527±0.14). The in vitro xanthine oxidase inhibitory activity was performed on ethanol and aqueous extracts (stem and root) of the plant and activity was found to be significant with IC50 59.21 and 148 μg mL-1 in both ethanol extracts. Further in-vivo antigout was studied gout induced in rats. Oral administration of stem and root ethanol extracts (200 and 400 mg kg-1 body weight) showed a significant decrease in uric acid, Creatinine, ESR (Erythrocyte Sedimentation Rate) and MDA (Malondialdehyde) levels in the gouty rats. A significant increase was observed in reduced glutathione. No change in protein content was noticed. In conclusion, the studied plant extracts showed significantly variable anti-gout activity associated with both antioxidant and anti-inflammatory effects which may be due to the presence of flavonoids, phenolics, saponins and triterpenoidal compounds revealed by preliminary phytochemical screening.
  Neeru Vasudeva , Geeta Rai and Surendra Kr. Sharma
  Butea monosperma is a commonly used plant in folk medicine in Indian subcontinent. The present investigation was undertaken to examine the anti-spermatogenic activity of the four successive extracts i.e., petroleum ether, chloroform, methanol and aqueous extracts of the root of B. monosperma. The in vitro studies on human sperms revealed that the petroleum ether and chloroform extracts at the concentration of 15 mg mL-1 caused significant immobilisation and reduction of sperm viability. The extracts caused irreversible damage to the sperms. Further, the effect of these extracts was assessed on the testis and epidydmis of the male albino mice at the dose of 200 mg kg-1 body weight. A significant decrease in the weight and changes in fructose, alkaline phosphate, total protein and cholesterol level in these organs of the treated mice when compared to control mice was observed. Histological studies of these organs were also performed.
  Surendra Kr. Sharm , Geeta Rai and Neeru Vasudeva
  The root of B. monosperma was successively extracted by solvents in increment of polarity. The extracts were administered orally at the dose of 200 mg kg-1 body weight to adult female mice of proven fertility for evaluation of anti-implantation activity. The extracts showing anti-implantation activity were further evaluated at the similar dose for estrogenic and anti-estrogenic activity in immature female mice. Biological and histological studies were also performed. Of the four extracts i.e., petroleum ether, chloroform, methanol and aqueous extracts, petroleum ether and chloroform extracts showed significant anti-implantation activity at dose 200 mg kg-1 body weight. Both these extracts showed anti-estrogenic effect. The weight of ovaries of petroleum ether and chloroform extracts treated animal reduced significantly (p<0.01) as compared to control. This was associated with an elevation in the level of cholesterol. Petroleum ether and chloroform extracts inhibited the activity of G-6-PDH to a significant (p<0.05, p<0.01) extent and thus indicating anti-steroidogenic activity of the extract. It may be concluded that petroleum ether and chloroform extracts possess some estrogen like compounds which may be responsible for anti-estrogenic activity of the extracts.
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