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Articles by Neelam Misra
Total Records ( 6 ) for Neelam Misra
  Ajay Kumar Gupta and Neelam Misra
  Hepatoprotective activity of aqueous ethanolic extract of Chamomile recutita capitula against paracetamol induced hepatic damage in albino rats was observed. In the present study the effect of aqueous ethanolic extract of Chamomile recutita capitula on blood and liver glutathione, Na+ K+- ATPase activity, serum marker enzymes, serum bilirubin, glycogen and thiobarbutiric acid reactive substances against paracetamol induced damage in rats have been studied to find out the possible mechanism of hepatoprotection. It was observed that extract of chamomile has reversal effects on the levels of above-mentioned parameters in paracetamol hepatotoxicity. The extract of capitula of chamomile functions as a hepatoprotective agent and this hepatoprotective activity of chamomile may be due normalization of impaired membrane function activity.
  Mohd. Saquib Ansari and Neelam Misra
  This study briefly focuses on the diverse role of Salicylic Acid (SA) in humans, in curing different diseases and in plants, in ameliorating biotic and abiotic stresses. SA has also been implicated in several other processes in plants like thermogenesis, flowering, germination, fruit yield, bioproductivity, etc. SA functions as a protective agent both in animal and plant systems. Thus, SA could aptly be called a wonder compound.
  Ajay K. Gupta , Havagiray Chitme , Sujata K. Dass and Neelam Misra
  Hepatoprotective activity of Aqueous Ethanolic Extract (AET) of rhizome of mature Rauwolfia serpentina against paracetamol induced hepatic damage in rats was investigated. The effect of AET of rhizome of R. serpentina on blood and liver glutathione, Na+K+-ATPase activity, serum marker enzymes, serum bilirubin and thiobarbutiric acid reactive substances, liver glutathione peroxidase, glutathione-S-tranferase, glutathione reductase, superoxide dismutase, catalase activity and glycogen against paracetamol induced damage in rats have been studied with a view to elucidate possible mechanism behind its hepatoprotective action. It was interesting to observe that AET of rhizome of Rauwolfia has reversal effects on the levels of above-mentioned parameters in paracetamol hepatotoxicity. It was observed that AET extract of Rauwolfia is a promising hepatoprotective agent and this hepatoprotective activity of Rauwolfia may be due to its antioxidant and normalization of impaired membrane function activity. A possible mechanism behind the results is discussed.
  Ajay Kumar Gupta , Havagiray Chitme , Sujata K. Dass and Neelam Misra
  Antioxidant activity of Methanolic Extract (MET) of capitula of Chamomile recutita was investigated in rats by inducing liver injury with CCl4. The MET exhibited significant antioxidant activity by showing increased levels of Glutathione Peroxidase (GPX), Glutathione-S-Transferase (GST), Glutathione Reductase (GRD), Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione (GSH). The decreased level of Lipid Peroxidation (LPO) has also been shown. The MET, at a dose level of 300 mg kg -1 showed significant antioxidant activity against CCl4 induced liver injury in rats. MET of C. recutita had been shown a potent and prominent free radical scavenging activity and CCl4-intoxicated liver recovery towards normalcy in the methanol extract co-administered rats revealed the effectiveness of C. recutita in combating oxidation stress due to hepatic damage. Thus, the MET possess antioxidant activities with combined hepatoprotective action has a synergistic effect to stabilize cellular membrane or antiperoxidase activity.
  Neelam Misra , Rajesh Luthra and Sushil Kumar
  Ajmalicine and serpentine are indole alkaloids of considerable medicinal importance. In Cathranthus roseus roots, the amount of serpentine is considerably higher as compared to that of ajmalicine. The crude alkaloid, ajmalicine and serpentine, per plant root biomass, increased from one leaf pair seedling stage to five stages. The increase was more pronounced with respect to serpentine. There is conformity between the time course of serpentine to ajmalicine ratio and that of the activity of peroxidase, the enzyme involved in the conversion of ajmalicine to serpentine. Ajmalicine is converted in vitro into serpentine by horseradish basic peroxidases (1.11.1.7). In C. roseus root extracts, since a high quantity of serpentine is associated with protein, the bioconversion results using HPLC are not conclusive. A radioactive procedure, involving the use of radio labeled 3H-ajmalicine, has been standardized for bioconversion studies. The 3H-ajmalicine was synthesized by sodium borotritide reduction of serpentine. Using labeled ajmalicine, it has been conclusively demonstrated that ajmalicine is converted efficiently into serpentine by peroxidase in C. roseus roots.
  Neelam Misra , Ajay Kumar Gupta and U.N. Dwivedi
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