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Articles by Nazmi Cetin
Total Records ( 2 ) for Nazmi Cetin
  Nazmi Cetin , Ugur Boyraz and Ebru Cetin
  The aim of this study was to evaluate the possible antioxidant effect of ghrelin against tilmicosin-induced myocardial damage in rats. Forty male Sprague Dawley rats were equally divided into four groups: control (saline for 5 days), tilmicosin (single dose of 75 mg kg‾1, s.c.), ghrelin (10 ng/kg/day for 5 days, s.c.) and ghrelin plus tilmicosin group (pretreatment with ghrelin followed by tilmicosin treatment). The heart were excised for evaluating Malondialdehyde (MDA) content, Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GPx) activity. The results showed that tilmicosin treatment alone significantly (p<0.05) elevated the levels of MDA and lowered the activities of SOD, CAT and GPx when compared with the control group. Pretreatment with ghrelin ameliorated the SOD, CAT and GPx activities and inhibited the levels of MDA production in the heart tissue compared to tilmicosin-treated rats. The results of the study provide evidence that the ghrelin pretreatment enhances the antioxidant defense against tilmicosin-induced myocardial oxidative injury in rats and exhibit cardioprotective property.
  Ebru Cetin , Berrin Kocaoglu Guclu and Nazmi Cetin
  This study was conducted to determine the anti-stress effect of the dietary humate and organic acid supplementation on laying hens when subjected to high stocking density as a social stress factor. A total of hundred, 40 weeks, brown laying hens were housed at two different stocking densities of 287.7 (high density) and 500 (low density) cm2/hen. For the control group, 16 hens were randomly assigned to 4 groups, 4 replicates of 4 birds each and were kept in low density. The control group received a basal diet. The remaining 84 hens were divided into 3 treatment groups, 4 replicates of 7 birds each and were housed at high density. The treatment group were fed either a basal diet (crowded control) or the basal diet supplemented with either 0.15 humate (Humate group) or 0.20 % organic acid (organic acid group) of diet for 60 days. The results show that in hens kept in high density heterophils and Heterophil to Lymphocyte (H:L) ratios, an indicator of stress were raised while lymphocytes decreased. Humate supplementation resulted in significant increases in the lymphocyte counts and significant decreases in the heterophil counts and H:L ratios compared with those of the crowded control. The heterophils, lymphocytes and H:L ratio were not influenced by organic acid treatment. The present results suggest that humate supplementation to diet may be a favorable alternative for help poultry to cope with social stresses.
 
 
 
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