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Articles by Nasrin Samadi
Total Records ( 3 ) for Nasrin Samadi
  Nasrin Samadi , Mojgan Alvandi , Mohammad Reza Fazeli , Ebrahim Azizi , Hadi Mehrgan and Mansour Naseri
  Polymerase Chain Reaction (PCR) was performed to verify the utility of this technique in detecting low levels of microbial contamination in quality control of pharmaceutical products. Universal and specific primers were applied to identify Staphylococcus aureus at both genus and species levels, as one of the objectionable microorganisms in pharmaceuticals especially topical products. Samples were deliberately inoculated with a defined number of bacterial cells and subsequently exposed to mild lysis. The crude lysate was subjected to PCR amplification. Agarose gel electrophoresis revealed amplified fragments as predicted, with no interference from other bacterial strains included in the study. The sensitivity of the assay was about 102 cfu mL-1 which improved to 1 cfu mL-1 after an overnight preenrichment. Combination of this simple lysis and rapid PCR protocol provided a highly sensitive and practical approach in detecting trace amounts of Staphylococcus aureus contamination in pharmaceutical preparations. In contrast to conventional culturing methods that require a mean of 5-6 days for identification of microorganisms, the entire mentioned PCR assay lasted about 1-2 h.
  Nasrin Samadi , Mohammad Reza Fazeli , Neda Abadian , Abbas Akhavan , Abbas Tahzibi and Hossein Jamalifar
  A bacterial strain was isolated from vegetable oil contaminated soil, identified and named as Brevibacterium sp. strain S-34. Hemolysis of erythrocytes and emulsification of the oil in culture media indicated surface active agents production by the strain. Thin layer chromatography studies revealed that the secreted biosurfactants were glycolipids. The potential production of biosurfactants is assessed using different carbon sources (glucose, glycerol, molasses, gasoline, Canola oil and waste oil). Optical density, pH and surface tension were employed to determine the biosurfactant activity of strain S-34 in mineral salts medium with each carbon source. The microorganism was able to grow well on glycerol (50 g L-1) and reducing the surface tension of medium from 69 mN m-1 to 30 mN m-1 by production of 2.4 g L-1 total biosurfactant after 72 h.
  Arash Mahboubi , Tahereh Hallaj Shooshtari , Mohammad Reza Fazeli , Rasoul Dinarvand , Nasrin Samadi , Mohammad Sharifzadeh , Houshmand Ilka , Saeed Azadi and Mahboubeh Valadkhani
  In this study the immunogenicity of four commercially available hepatitis B recombinant vaccines in Iran was compared. The vaccines included both the well known brand of Engerix-B and three biosimilars of Heberbiovac HB, Euvax B and Hepavax-Gene. Vaccines were administered intra-peritoneally (i.p) to Balb/C mice and the immune responses were evaluated by comparing the Geometric Mean Titer (GMT), the rate of seroconversion, seroprotection, ED50 as well as the relative potency of the vaccines. The GMT (mIU mL-1) obtained for Heberbiovac-HB was at least six folds of the other vaccines while its ED50 (ng) was also the lowest among the tested formulations. Similar results were obtained when the seroconversion and seroprotection of Heberbiovac-HB was compared to the others. The relative potency of Heberbiovac-HB was 30.13 (μg dose-1) which was well above the figures obtained for other vaccines. The results of immunogenicity markers in Balb/C mice of Heberbiovac-HB, a biosimilars hepatitis B vaccine in Iranian market was well above the well-known brand of Engerix-B but those figures obtained for other biogenerics were far behind those of Engerix-B. These results tend to suggest the important role of post marketing surveillance studies conducted by the national regulatory authorities in selecting the right products in national immunization programs.
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