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Articles by Naser A. ElSawy
Total Records ( 2 ) for Naser A. ElSawy
  Hassan M. Bukhar , Naser A. ElSawy and Eslam A. Header
  Several studies suggest that there was relationships between energy drink consumption and problem behaviors among adolescents and adults as it increase lipolysis glycogenolysis and catecholamine secretion. This study aimed to find out the potential effects of high energy drinks recommended intake and toxic dose on normal and hyperglycemic rats. Thirty-six (36) male adult Sprague-Dawley rats weighting 145±5.3 g each were used in this investigation. Non-diabetic rats [control-ve 6 rats feed on basal diet only and 12 Normal Rats (NR) divided into two groups consumed basal diet with 1 and 2 ml of High Energy Drink (HED) by gastric tube], while Diabetic Rats (DR) control+ve 6 rats received basal diet only and 12 rats divided into two groups consumed basal diet with 1 and 2 ml of HED after injected with alloxan for inducing diabetes mellitus. Body Weight Gain (BWG) and food intake were recorded weekly for 6 weeks. Blood samples were collected after 12 hours fasting at the end of experiment. Liver was removed and weighted. Blood serum was prepared for measurements of glucose, triglyceride, cholesterol, HDL-c, LDL-c, VLDL-c, AST, ALT and ALP. The BWG of NR groups received 2 ml only and DR groups received 1 and 2 ml of HED by oral injection recorded significant decrease (p<0.001) as compared to the control negative group. Blood glucose level was significantly higher (p<0.001) for DR fed on 1 and 2 ml compared with control (-). Serum AST, ALT and ALP were significantly higher (p<0.01 and p<0.001 resp.) for NR received the two doses of HED compared with normal rats control (-). As for cholesterol, triglycerides and LDLc levels were significantly higher (p<0.01) in the hyperglycemic rats group fed on 2 ml of HED compared with control (-). Also LDLc/HDLc ratio increased gradually when the level of HED increased. Oral injection by HED cause histopathological changes in the liver for NR and DR like atrophy and cell damage also changes in the chemical and morphological structure.
  Osama A. Kensara , Naser A. ElSawy and Eslam A. Header
  Different metabolic disorders including hypertension cause renal damage. The aim of this study was to study the effect of Thymus Vulgaris (TV) on kidneys of induced hypertensive rats through biochemical and ultrastructure examination. Thirty three adult male albino rats were divided into 3 groups 11 animals each (control, untreated and treated). The first (control) group was fed and followed up for 8 weeks by measuring the systolic BP. In the second group, hypertension was induced by ligation of left renal artery to have systolic BP >150 mmHg and was followed up till the end of study. The third group in which hypertension was induced were given TV as 100 mg/kg body weight daily. The surviving 11 rats per each group were weighed again and killed with an overdose of phenobarbital and blood was collected to measure the blood chemistry. Following laparotomy, right kidney was dissected and excised from each rat and divided into 2 parts: one part was immersed in 10% formal saline and prepared for light microscopic examination. The other parts was immersed into 2.5 % glutaraldehyde and prepared for electron microscopic examination using transmission microscopy in faculty of medicine Zagazig university Egypt. A Significant increased was noticed in creatinine and cholesterol in untreated in contrast to control and treated hypertensive rats. There was significant reduction of Blood Pressure (BP) on using TV in contrast to untreated group. In untreated hypertensive group some cortical fields showed scars surrounding obsolete shrinkage glomeruli with inflammatory infiltrates with reciprocal dilatation of their Bowman's capsules. Ultrastructure examination showed thick glomerular endothelium with obliterated endothelial fenestrations. In treated hypertensive group the rat kidneys showed preserved cortical appearance and normal trilaminar structure but with focal thickening. Induced hypertension in rats affected renal tissues with biochemical alterations which all can be improved and/or prevented by using Thymus vulgaris herbal extract.
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