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Articles by Nan Li
Total Records ( 9 ) for Nan Li
  Huanzhuo Ye , Nan Li , Hao Feng and Yonghua Wang
  The financial institutions concern on the customer credit evaluation. Highly effective and accurate evaluation models can help the financial institutions to reduce the risk and loss. There are several commonly used evaluation models, for example, the logistic regression, decision tree, support vector machine, artificial neural network, etc. We use the same data set to test these models and give the advantages and disadvantages of these models. Among these models, there is not a unified view that which model is the best because eacxh one has their advantages. The logistic regression is the most stable model while the decision tree is the lowest. in stability, MLP-ANN has the better accuracy rate than other models.
  Jinfeng Han , Nan Li and Yushan Wang
  Background and Objective: Adequate fluid removal may decrease the mechanical ventilation time in intensive care. Ethacrynic acid as diuretic required comparatively in fewer dose than furosemide. The objective of the study was to compare the efficacy and safety of ethacrynic acid with furosemide in fluid overload patients associated with cardiac intensive care. Materials and Methods: A total of 248 patients with signs of volume overload in the cardiac intensive care unit were subjected to randomize. Patients were received 0.8 mg kg1 h1 of furosemide (FR group, n = 124) or 0.5 mg kg1 h1 ethacrynic acid (EA group, n = 124) at 1 mL h1, for maximum 3 days. Serum creatinine, urine output, body weight loss, cost of interventions and treatment-emergent adverse effects were evaluated. The Chi-square for independence or one-way ANOVA was performed at 95% of confidence level. Results: Furosemide and ethacrynic acid, both decreased serum creatinine and increased urine output. Patients of FR group had high weight loss than EA group at the time of discharge (p<0.0001). Hypocalcemia and hypomagnesemia had been reported in FR group and tinnitus and hearing loss had been reported in EA group during the follow-up period. Ethacrynic acid treatment was highly expensive treatment than frusemide (p<0.0001). Conclusion: Ethacrynic acid is safe and effective but costly alternative of frusemide.
  Xin you Su , Jian Qiang Zhao , Nan Li , Mukesh Kumar and Ai mei Ou yang
  Background and Objective: Hepatocellular carcinoma (HCC) is the major threat to the human health and it has got 6th rank among all types of cancers and 3rd leading cause of cancer related death. The HCC patients have high mortality rate. Resveratrol (natural phenol) participate in a significant way in the formation of the cell membrane and also play a significant role in functioning of membrane fluidity and proteins. This study was aimed to examine the anticancer effect of resveratrol (RT) against diethylnitrosamine (DEN) induced HCC in Wistar rats. Materials and Methods: For the current experimental study, the Wistar rats were used and an intraperitoneal dose of DEN (200 mg kg–1) was given to them for the induction of HCC. The rats received various doses of RT for 22 weeks. The progressions of serum biomarkers and macroscopical components of hepatic tissue were used to access the prophylactic effects. The antioxidant parameters, cancer preventive agent status and apoptosis mechanism were reviewed to scrutinize the possible mechanism. Results: The RT treatment significantly (p<0.001) altered the hepatic nodules, body weight and hepatic, antioxidant, non-hepatic parameters in a dose-dependent manner. The macroscopical observation exhibited the hepatic nodules in DEN-induced rat’s liver and dose-dependent treatment RT significantly reduced the formation of hepatic nodules and decolourization of tissue. Curiously, the expression of β-arrestin-2, Bcl-xal and Bcl-2 were significantly (p<0.001) reduced and expression of caspase-3 and Bax was significantly (p<0.001) increased at the dose-dependent manner of RT treatment. Conclusion: On the basis of result, the authors concluded that the RT exhibited the defensive effect against the DEN-induced HCC that might be due to antioxidant effect and actuation of apoptosis.
  Jin Shen , Nan Li , Yanwei Mao , Yimin Zhang and Xin Luo
  Protein changes induced by low-voltage Electrical Stimulation (ES; 42V for 40 sec) in the insoluble protein fraction of bovine Longissimus Dorsi (LD) muscle at 3 days post-ES were investigated by proteomics. Protein abundance patterns from ten Chinese yellow crossbred bulls were compared and significant changes due to ES were found. Seven protein spots showed lower expression abundance in 3 days post-ES samples including myofibrillar and cytoskeletal protein (myosin binding protein H, histone H3.3-like isoform 2) two metabolic enzymes (creatine kinase, triosephosphate isomerase) and an unnamed protein due to ES. Reduced abundance of these proteins in ES samples indicated an accelerated proteolysis due to ES which finally improves tenderness. The most important finding was that an unnamed protein product was found to change in abundance due to ES at 3 days post-ES and this protein could provide a new target as a potential meat quality biomarker. These findings provided a better understanding of the biochemical processes taking place as a result of ES during postmortem storage of meat.
  Nan Li , Fenghua Lu , Peng Zhu , Qingyou Liu , Jiangrong Jiang and Deshun Shi
  O-linked β-N-Acetylglucosamine Glycosylation (O-GlcNAc) is one of the main types of glycosylation in mammalian cells while Glucosamine (GlcN) is an O-GlcNAc substrate. Thus, effects of GlcN on the embryonic development, level of O-GlcNAc and related gene expression of buffalo embryos were examined in this study. Buffalo zygotes derived from In Vitro Fertilization (IVF) were randomly allocated into culture in the medium supplemented with different concentration of GlcN (0, 1, 2 and 4 mM) during the different culture period (0-72, 72-172 and 0-172 h). When GlcN was added to the medium in the culture period of 0-72 h after IVF, addition of 2 mM GlcN resulted in more zygotes developing to blastocysts (26.1%) in comparison with control (14.3%), 1 mM (13.6%) and 4 mM (11.3%) groups (p<0.05). However, the blastocyst yield decreased gradually when GlcN was added to the medium during 72-172 h of culture and decreased significantly when the concentration of GlcN was arrived at 4 mM (3.1 vs. 14.2%, p<0.05). When GlcN was added to the medium in the whole culture period (0-172 h) there were no significant difference in either cleavage rate or blastocyst yield among the four groups (p>0.05). Immunofluorescence analysis revealed that addition of 2 mM GlcN to medium from 0-72 h after IVF resulted in a significant increase (p<0.05) in the O-GlcNAc level of embryos at 2, 4, 8 cells and morula stage with the exception of blastocysts. QRT-PCR revealed that culture of zygotes with 2 mM GlcN in the culture period of 0-72 h after IVF resulted in a significant increase (p<0.05) in the expression of O-GlcNAc transferase gene in the embryos at the 2, 4, 8 cells and morula stage and did not affect the expression of O-GlcNAc-selective N-acetyl β-D-glucosaminidase gene. These results indicate that appropriate concentration of GlcN can improve the development of buffalo embryos and this action is stage dependent and mediated by O-GlcNAc transferase gene.
  Yingjun Li , Lijia Teng , Limin Shang , Ruilin Ma , Jinshan Cai , Quanbang Zhao , Jiping Li , Nan Li and Quan Liu
  The present study was conducted to investigate tick species and tick-transmitted Theileria and Babesia species in Qinghai Province, Northwestern China. A total of 357 ticks, belonging to 2 Ixodid genera, Haemaphysalis qinghaiensis (167; 46.8%) and Dermacentor nuttalli (190; 53.2%) were collected from the domestic animals during May and June 2010. The ticks were separated into 78 tick pools according to their species and examined for Theileria and Babesia species by a nested PCR targeting 18S rRNA gene. Of the 25 H. qinghaiensis pools, 2 (8.0%) were tested positive for Theileria. Only 1 (1.9%) was tested positive for Babesia in 53 D. nuttalli pools. The sequence and phylogenetic analyses showed that Babesia and Theileria detected in this study were grouped into B. caballi and T. luwenshuni, respectively implying the potential existence of theileriosis and babesiosis in animals in Qinghai Province.
  Nan Li , Peizhen Fu , Yicheng Wu and Jianxiu Zhang
  Single crystals of ZnBi2B2O7 (ZBBO) have been successfully grown by the top-seeded growth method from a high-temperature melt. The crystal was colorless and transparent with size of 15×10×5 mm3. The orientation of ZBBO crystal has been discussed. The melting point, molar enthalpy of fusion, and molar entropy of fusion of the crystal were determined to be 964.02 K, 110680.36 J mol−1, and 113.92 J K−1 mol−1, respectively. The transparency range of the crystal extends from 370 to 2100 nm.
  Xiaojian Wang , Bin Liu , Nan Li , Hongzhe Li , Jianming Qiu , Yuanyuan Zhang and Xuetao Cao
  Protein phosphatase 1 (PP1) is a major serine/threonine phosphatase that controls gene expression and cell cycle progression. Here we describe the characterization of a novel inhibitory molecule for PP1, human inhibitor-5 of protein phosphatase 1 (IPP5). We find that IPP5, containing the PP1 inhibitory subunits, specifically interacts with the PP1 catalytic subunit and inhibits PP1 phosphatase activity. Furthermore, the mutation of Thr-40 within the inhibitory subunit of IPP5 into Ala eliminates the phosphorylation of IPP5 by protein kinase A and its inhibitor activity to PP1, whereas the mutation of Thr-40 within a truncated form of IPP5 into Asp can serve as a dominant active form of IPP5 in inhibiting PP1 activity. In IPP5-negative SW480 and IPP5-highly positive SW620 human colon cancer cells, we find that overexpression of IPP5 promotes the growth and accelerates the G1-S transition of SW480 cells in a Thr-40-dependent manner, which could be reversed by downregulation of the PP1 expression. Moreover, silencing of IPP5 inhibits the growth of SW620 cells both in vitro and in nude mice possibly by inducing G0/G1 arrest but not by promoting apoptosis. According to its role in the promotion of cell cycle progression and cell growth, IPP5 up-regulates the expression of cyclin E and the phosphorylated form of retinoblastoma protein. Our findings suggest that IPP5, by acting as an inhibitory molecule for PP1, can promote tumor cell growth and cell cycle progression, and may be a promising target in cancer therapeutics in IPP5-highly expressing tumor cells.
  Chunmei Wang , Nan Li , Xingguang Liu , Yuanyuan Zheng and Xuetao Cao
  Calcium/calmodulin-dependent protein kinase II (CaMKII) regulates numerous physiological functions. Inhibition of CaMKII activity, mostly by synthetic reagents, has been proved to suppress cell growth in many cases. So far there are no reports about the physiological functions and underlying mechanisms of endogenous CaMKII inhibitory proteins in cell cycle progression. Here we report the characterization of a novel human endogenous CaMKII inhibitor, human CaMKII inhibitory protein α (hCaMKIINα), which directly interacts with activated CaMKII and effectively inhibits CaMKII activity. hCaMKIINα expression is negatively correlated with the severity of human colon adenocarcinoma. Overexpression of hCaMKIINα inhibits colon adenocarcinoma growth in vitro and in vivo by arresting the cell cycle at the S phase through its conserved inhibitory region (27CIR), whereas silencing the hCaMKIINα expression accelerates tumor growth and cell cycle progression. We found that the effect of hCaMKIINα on cell cycle is correlated with up-regulation of p27 expression, which may be due to the inhibition of proteasome degradation, but not transcriptional regulation, of p27. Moreover, hCaMKIINα deactivated MEK/ERK, which is prerequisite to the inhibition of Thr-187 phosphorylation and subsequent proteasomal degradation of p27, causing the inhibition of S-phase progression of cell cycle. The findings underscore a link between hCaMKIINα-mediated inhibition of CaMKII activity and p27-dependent pathways in controlling tumor cell growth and cell cycle and imply a potential application of hCaMKIINα in the therapeutics of colon cancers.
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