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Articles by Namasivayam Senthil
Total Records ( 3 ) for Namasivayam Senthil
  Namasivayam Senthil , Shanmugam Manoharan , Subramanian Balakrishnan , Cinnamanoor Rajmani Ramachandran and Radhakrishnan Muralinaidu
  Aim of the present study was to find out the chemopreventive efficacy of Piper longum, a plant having diverse medicinal properties, in 7,12-dimethyl benz (a) anthracene (DMBA) induced oral carcinogenesis. The mechanistic pathway for its chemopreventive potential was analysed by measuring lipid peroxidation and antioxidants status in DMBA induced oral cancer. DMBA painting in hamster buccal pouch three times per week for 14 weeks resulted in well developed, well differentiated squamous cell carcinoma. Elevated lipid peroxidation and decline in antioxidants were noticed in tumor bearing hamsters as compared to control animals. Oral administration of ethanolic extract of Piper longum dried fruits (PLEFet) on alternate days to DMBA painting significantly prevented the tumor incidence, volume and burden and restored the status of lipid peroxidation and antioxidants in DMBA painted hamsters. Our results indicate that the dried fruits of P. longum has suppressing effects on cell proliferation, which is probably due to its antilipid peroxidative and antioxidative potential during DMBA induced oral carcinogenesis.
  Kathiresn Suresh , Shanmugam Manoharan , Kuppusamy Panjamurthy and Namasivayam Senthil
  Present aim was to study the modifying effects of Annona squamosa leaf extracts in 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis. Oral squamous cell carcinomas were induced in buccal pouches of Syrian golden hamsters by painting with 0.5% 7,12-dimethylbenz(a)anthracene in liquid paraffin three times per week for 14 weeks. The incidence of total number of tumors, tumor burden and tumor volume were recorded in 7,12-dimethylbenz(a)anthracene painted hamsters. The status of glycoconjugates in plasma, erythrocyte membranes and tumor tissues were analysed in tumor bearing hamsters and Annona squamosa leaf extracts treated 7,12-dimethylbenz(a)anthracene painted hamsters. Oral administration of aqueous and ethanolic extracts of Annona squamosa leaf extracts at a dose of 500 mg kg-1 body weight and 300 mg kg-1 bodyweight respectively, reduced the tumor formation as well as protected the levels of glycoconjugates in 7,12-dimethylbenz(a)anthracene painted hamsters during carcinogenesis. Present study suggests that A. squamosa leaf extracts have potent chemopreventive efficacy and can modify the abnormalities in cell surface glycoconjugates during neoplastic transformation.
  Gopi Lilly Renju , Shanmugam Manoharan , Subramanian Balakrishnan and Namasivayam Senthil
  The present study has investigated the chemopreventive and antilipidperoxidative effects of the ethanolic extract of Clerodendron inerme leaves (CiELet) in DMBA induced skin carcinogenesis in Swiss albino mice. The skin squamous cell carcinoma was induced in the shaved back of mice, by painting with DMBA (25 μg 0.1 mL-1 acetone) twice weekly for 8 weeks. We have observed 100% tumor formation in the fifteenth week of experimental period. Elevated lipid peroxidation and decline in enzymatic and non-enzymatic antioxidants status was observed in tumor bearing mice. Oral administration of CiELet (300 mg kg-1 bw) for 25 weeks significantly prevented the tumor incidence, volume and burden of the tumor. The CiELet also showed potent antilipidperoxidative effect as well as enhanced the antioxidant defense mechanisms in DMBA painted mice. The present study thus demonstrated the chemopreventive and antilipidperoxidative efficacy of CiELet in DMBA induced mouse skin carcinogenesis.
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