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Articles by Nahla S. El-Shenawy
Total Records ( 4 ) for Nahla S. El-Shenawy
  Rasha A. Al-Eisa , Reham Z. Hamza , Amir E. Mehana and Nahla S. El-Shenawy
  Background and Objective: Aspartame (ASP) one of the famous artificial sweeteners used as substitution of the sugar in foods and beverages. The study was aimed to investigate the oxidative responses and histopathological changes induced by ASP on the kidney of rats and the ameliorative role of L-carnitine (LC) to prevent the toxicity. Materials and Methods: Rats were split into six groups (n = 8) as follow: control, ASP (low dose, LD) (75 mg kg–1), ASP (high dose, HD) (150 mg kg–1), 10 mg kg–1 of LC, ASP-LD+LC and ASP-HD+LC, all groups treated for successive 30 days. Results: The ASP marked decreased the renal levels of reduced glutathione (GSH), activities of antioxidant enzyme markers and increased lipid peroxidation levels. DNA damage was significantly increased in ASP-LD and ASP-HD groups as compared to control animals. The LC prevented the ASP-induced kidney damage as specified by ameliorating all the above-mentioned parameters. Histopathological changes were parallel with the biochemical alternation in ASP groups. Conclusion: The renal toxicity induced by ASP in rats could be improved by LC through different protective mechanisms.
  Fawziah A. Al-Salmi , Rasha Al-Eisa , Reham Z. Hamza , Howayda E. Khaled and Nahla S. El-Shenawy
  Background and Objective: Sodium Valproate (SV) is a medicine that is used to treat epilepsy and to prevent headache. In this study, L-cysteine (LC) was used to decrease the stress and biochemical variations induced by SV treatment. The present study investigated the defensive actions of LC vs, SV that induced testicular impairment. Materials and Methods: The rats were split into six groups (n = 10) as following: 1st control animals were saline-treated, 2nd and 3rd groups were administrated two doses of SV (100 and 500 mg kg1 b.wt.) presenting low and high doses, respectively, 4th group was treated with 100 mg kg1 of LC, in addition 5th and 6th groups were treated with SV-LD+LC and SV-HD+LC, respectively. The experiment was run for 30 successive days. Weights of the testis, serum testosterone, testicular oxidative/anti-oxidant capacity and histopathological damage scores of testis were recorded. Results: The SV group had significantly increased the tissue oxidative stress markers and significantly declined all antioxidant enzymes activities as compared to the control group. When the animals treated with combination of LC and any dose of SV, levels of oxidative parameters significantly declined, as well as the anti-oxidant significantly elevated compared to the SV-LD and SV-HD groups. The Johnsen's testicular score values showed improvement when LC was co-treated with the SV. Conclusion: Current results indicated that LC had partial protective effects against SV-induced testis damage at the biochemical and histopathological levels that could be due to the enhanced tissue anti-oxidant capacity.
  Nahla S. El-Shenawy , Richard Greenwood , Zohour I. Nabil , Ismail M. Abdel-Nabi and Raafat A. Hanna
  A study was carried out to evaluate the acute and chronic toxicity of lindane and atrazine in Mytilus edulis. The threshold median lethal dose for lindane was approached at long elapsed times (90 days) when the LC50 was 1.7 mg l-1. The LT50 at a concentration of 30 mg l-1 was 8.4 days which appears to be approaching the limiting time. For atrazine the median lethal threshold concentration was not reached even at the lowest dose (1.25 mg l-1) used and after 112 days the LC50 was 1.6 mg l-1. Similarly a limiting time was not reached even at the highest does (30 mg l-1) when the LT50 was 1.7 days. More marginal concentration and time effects (LC90 and LC10; LT90 and LT10) were also estimated for lindane and atrazine using probit analysis. Valve movement response of the mussels during acute and chronic bioassay toxicity of the pesticides was evaluated as biomarker. The data indicated that the rest period increased with increasing concentration and time of exposure. It could be concluded that there is a time-dose-response relationships of lindane and atrazine with mussels (Mytilus edulis).
  Reham Z. Hamza , Fawziah A. Al-Salmi and Nahla S. El-Shenawy
  Background and Objective: The potential benefit of green synthesis zinc oxide nanoparticles (ZnO NPs) is still a deprecatory issue. The aim of the present research was to elucidate the anti-hyperlipidemia of green tea leaves extract (GTE)/ZnO NPs complex against monosodium glutamate (MSG). Materials and Methods: Eight different groups of male rats were used: Group I was the control, group II received GTE (1 mg mL–1), group III was treated with ZnO NPs (10 mg kg–1), groups IV and V received MSG in two different doses (6.0 and 17.5 mg kg–1), group VI treated with ZnO NPs/GTE complex, groups VII and VIII were given ZnO NPs/GTE complex plus MSG in different doses. The effect of ZnO NPs/GTE complex against MSG toxicity through studying the alteration of enzyme activity of liver functions [alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALK) and γ-glutamyl transferase (γ-GT)] and lipid profile alternation have been described. The rats that were given MSG only had a highly significant elevation in liver enzymes and severe lipid metabolism changes. Results: The findings for group VII and VIII clarify the efficacy of ZnO NPs/GTE complex as a hepato-protectant on MSG alone through improving the liver enzyme activity along with the lipid profile. The activities of ALT, AST, LDH, ALP and γ-GT in the serum were significantly reduced. Conclusion: ZnO NPs/GTE complex was proved to be a potential hepatoprotective as it significantly ameliorates the hepatotoxicity induced by MSG through hyperlipidemia reducing effect.
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