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Articles by Nagwa A. El-Esnawy
Total Records ( 1 ) for Nagwa A. El-Esnawy
  Nagwa A. El-Esnawy and Wahiba A. Zarouk
  The aim of this study was to detect blood Transmitted Transfusion Virus (TTV) among Hepatocellular Carcinoma (HCC) patients and investigate the genetic diversity of an isolated TTV strain. Fifty blood samples of patients with HCC non-A through non-G hepatitis were collected and 25 blood donors as controls. TTV DNA was detected by the second generation of TTV PCR primers (NG059, NG061, NG062 and NG063) after extraction of DNA from 50 μL serum. TTV DNA was detected in 90% (45/50) of HCC patients and the prevalence in control group was 40% (10/25). To assess genetic heterogeneity of the TTV genome in more detail, a sequence analysis of PCR fragments, amplified from open reading frame 1 (ORF1) was performed. A total of 137 bp PCR fragments were sequenced and compared to sequences derived from the corresponding TTV genome region deposited in Gen Bank. Present sequencing was closely related to TTV-like mini virus, complete genome (Accession NC_002195), at nucleotide number 855 to 1019. The phylogenetic analysis suggested that present strain might be sub-strain or mutation from the parent gene 2195. These observations suggest a high degree of genetic complexity within the TTV population.
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